Cao Huang, MD

Contact Dr. Huang

1020 Locust Street
506 JAH
Philadelphia, PA 19107

(215) 506-9153

Most Recent Peer-reviewed Publications

  1. Impaired 26s proteasome assembly precedes neuronal loss in mutant ubqln2 rats
  2. Detergent-insoluble inclusion constitutes the first pathology in PFN1 transgenic rats
  3. UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway
  4. Riluzole exhibits no therapeutic efficacy on a transgenic rat model of amyotrophic lateral sclerosis
  5. Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats
  6. Temporal expression of mutant TDP-43 correlates with early amyotrophic lateral sclerosis phenotype and motor weakness
  7. Increased Ubqln2 expression causes neuron death in transgenic rats
  8. Identification of TMEM230 mutations in familial Parkinson's disease
  9. Pathogenic Ubqln2 gains toxic properties to induce neuron death
  10. Profiling the genes affected by pathogenic TDP-43 in astrocytes
  11. Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation
  12. Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
  13. Reactive astrocytes secrete lcn2 to promote neuron death
  14. Pathogenic mutation in VPS35 impairs its protection against MPP+ cytotoxicity
  15. XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats
  16. Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats
  17. Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
  18. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
  19. Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice
  20. Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake
  21. TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice
  22. Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
  23. Sustained Expression of TDP-43 and FUS in Motor Neurons in Rodent's Lifetime
  24. Developing tTA transgenic rats for inducible and reversible gene expression
  25. A tightly regulated Pol III promoter for synthesis of miRNA genes in tandem