Guiyun Zhang, MD, PhD

Haifeng Yang, PhD

Contact Dr. Yang

1020 Locust Street
JAH 336D
Philadelphia, PA 19107

(215) 503-6163

Most Recent Peer-reviewed Publications

  1. Erratum: Correction: Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer (eLife (2018) 7 PII: e69256)
  2. PBRM1 suppresses tumor growth as a novel p53 acetylation reader
  3. PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth
  4. Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine
  5. High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1
  6. Multiple tumor suppressors regulate a hif-dependent negative feedback loop via ISGF3 in human clear cell renal cancer
  7. Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma
  8. Immunohistochemistry successfully uncovers intratumoral heterogeneity and widespread co-losses of chromatin regulators in clear cell renal cell carcinoma
  9. The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
  10. The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer
  11. The contributions of HIF-target genes to tumor growth in RCC
  12. The roles of VHL-dependent ubiquitination in signaling and cancer
  13. The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C
  14. The von hippel-lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR
  15. pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2
  16. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
  17. Analysis of von Hippel-Lindau Hereditary Cancer Syndrome: Implications of Oxygen Sensing
  18. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
  19. Structure of an HIF-1α-pVHL complex: Hydroxyproline recognition in signaling
  20. Molecular pathogenesis of the von Hippel-Lindau hereditary cancer syndrome: Implications for oxygen sensing
  21. Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
  22. HIFα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
  23. Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation
  24. Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses
  25. Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A