Guiyun Zhang, MD, PhD

Haifeng Yang, PhD

Contact Dr. Yang

1020 Locust Street
JAH 336D
Philadelphia, PA 19107

(215) 503-6163

Most Recent Peer-reviewed Publications

  1. PBRM1 suppresses tumor growth as a novel p53 acetylation reader
  2. Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine
  3. PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth
  4. High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1
  5. Multiple tumor suppressors regulate a hif-dependent negative feedback loop via ISGF3 in human clear cell renal cancer
  6. Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma
  7. Immunohistochemistry successfully uncovers intratumoral heterogeneity and widespread co-losses of chromatin regulators in clear cell renal cell carcinoma
  8. The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
  9. The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer
  10. The contributions of HIF-target genes to tumor growth in RCC
  11. The roles of VHL-dependent ubiquitination in signaling and cancer
  12. The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C
  13. The von hippel-lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR
  14. pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2
  15. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
  16. Analysis of von Hippel-Lindau Hereditary Cancer Syndrome: Implications of Oxygen Sensing
  17. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
  18. Structure of an HIF-1α-pVHL complex: Hydroxyproline recognition in signaling
  19. Molecular pathogenesis of the von Hippel-Lindau hereditary cancer syndrome: Implications for oxygen sensing
  20. Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF