Philadelphia University + Thomas Jefferson University

Division of Surgical Research

Research is at the heart of the mission of the Department of Surgery. Projects in basic science and clinical research have included establishing ECMO capabilities to support critically ill neonates, developing hepatic resection and transplantation techniques, understanding the molecular aspects of pancreatic, breast, and ovarian cancers, and examining endothelial-cell, prosthetic-graft interactions.

The diverse interests of Jefferson's faculty allow for a multitude of cross-specialty protocols. The connections between clinically-based faculty and research-based faculty help facilitate a translational and collaborative approach to research.

Clinical Research

  • multimodality therapy in pancreatic and colorectal carcinoma
  • preoperative chemotherapy in locally advanced breast carcinoma
  • various randomized trials related to transplant surgery and pancreatic surgery

Basic Science Research

  • Endothelial-cell and leukocyte migration under conditions of sheer stress
  • Skeletal muscle biochemistry and function as it relates to myocardial assistance for failing hearts
  • Pathobiology of arterial wall cells associated with various peripheral vascular disease states
  • The role of the pancreatic renin angiotensin system (RAS) in type 1 diabetes
  • Osteopontin role in type 1 diabetes
  • Understanding the role of mRNA stability in pancreatic cancer cells
  • Understanding the role of mRNA stability in the tumor microenvironment
  • Trying to optimize current therapies and develop new therapies for the treatment of different cancers (e.g., ovarian and pancreatic)
  • Understanding the role of caloric intake in regards to pancreatic cancer development
  • Trying to identify novel early detection markers for pancreatic cancer

Jonathan R. Brody, PhD
Division Director
Vice Chair for Research,
Department of Surgery