Philadelphia University + Thomas Jefferson University

PhD Programs
Students


Current Students

Ariele Baggett

Ariele Baggett
Laboratory of: Shey-Shing Sheu, PhD

Ariele.Baggett@jefferson.edu

 


Morgan Basta

Morgan Basta
Laboratory of: TBD


Morgan.Basta@jefferson.edu

 


Ariana Entezari

Ariana Entezari
Laboratory of: TBD


Ariana.Entezari@jefferson.edu

 


Olivia Ottone

Olivia Ottone
Laboratory of: Makarand Risbud, PhD

Olivia.Ottone@jefferson.edu

 


Grace Tartaglia

Grace Tartaglia
Laboratory of: Andrew South, PhD

Grace.Tartaglia@jefferson.edu

 


Andrew Sinensky (MD/PhD)

John Han
Laboratory of: Nancy Philp, PhD

John.Han@jefferson.edu

Publications: Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells. Swarup A, Samuels IS, Bell BA, Han JYS, Du J, Massenzio E, Abel ED, Boesze-Battaglia K, Peachey NS, Philp NJ. Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C121-C133. doi: 10.1152/ajpcell.00410.2018. Epub 2018 Nov 21. PMID: 30462537

Impact of MCT1 Haploinsufficiency on the Mouse Retina. Peachey NS, Yu M, Han JYS, Lengacher S, Magistretti PJ, Pellerin L, Philp NJ. Adv Exp Med Biol. 2018;1074:375-380. doi: 10.1007/978-3-319-75402-4_46. PMID: 29721966
Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Swarup A, Bell BA, Du J, Han JYS, Soto J, Abel ED, Bravo-Nuevo A, FitzGerald PG, Peachey NS, Philp NJ. Exp Eye Res. 2018 Jul;172:45-53. doi: 10.1016/j.exer.2018.03.021. Epub 2018 Mar 28. PMID: 29604281


Andrew Sinensky (MD/PhD)

Shira Johnston
Laboratory of: Makarand Risbud, PhD

Shira.Johnston@jefferson.edu

 


Manan Damani

Manan Damani
Laboratory of Joannes Hoek, PhD

Manan.Damani@jefferson.edu

 


Alexus Kolb

Alexus Kolb
Laboratory of Karen Bussard, PhD

Alexus.Kolb@jefferson.edu

Publications: Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment. Kolb AD, Shupp AB, Mukhopadhyay D, Marini FC, Bussard KM. Breast Cancer Res. 2019 Feb 27;21(1):31. doi: 10.1186/s13058-019-1117-0.  PMID: 30813947

Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts. Shupp AB, Kolb AD, Mukhopadhyay D, Bussard KM. Cancers (Basel). 2018 Jun 4;10(6). pii: E182. doi: 10.3390/cancers10060182. Review. PMID: 29867053


Carolyn Chen (MD/PhD)

Carolyn Chen (MD/PhD)
Laboratory of Renato Iozzo, MD, PhD (Honoris Casusa)

Carolyn.Chen@jefferson.edu

Publications: Methods for Monitoring Matrix-Induced Autophagy. Chen C, Kapoor A, Iozzo RV. Methods Mol Biol. 2019;1952:157-191. doi: 10.1007/978-1-4939-9133-4_14. PMID: 30825174


Jeffrey Rappaport (MD/PhD)

Jeffrey Rappaport (MD/PhD)
Laboratory of Scott Waldman, MD, PhD

Jeffrey.Rappaport@jefferson.edu

Publications: The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. Rappaport JA, Waldman SA. Front Oncol. 2018 Aug 6;8:299. doi: 10.3389/fonc.2018.00299. eCollection 2018. Review. PMID: 30131940

GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress.
Kraft CL, Rappaport JA, Snook AE, Pattison AM, Lynch JP, Waldman SA. Oncotarget. 2017 Oct 26;8(61):102923-102933. doi: 10.18632/oncotarget.22084. eCollection 2017 Nov 28. PMID: 29262534

GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. Cancer Res. 2017 Sep 15;77(18):5095-5106. doi: 10.1158/0008-5472.CAN-17-0859. PMID:28916678

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.  Aka AA, Rappaport JA, Pattison AM, Sato T, Snook AE, Waldman SA.  Expert Rev Clin Pharmacol. 2017 May;10(5):549-557. doi: 10.1080/17512433.2017.1292124. Epub 2017 Apr 10. Review. PMID: 28162021

Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA. Infect Immun. 2016 Sep 19;84(10):3083-91.doi: 10.1128/IAI.00639-16. PMID: 27481254


Megan Roche

Megan Roche
Laboratory of Ubaldo Martinez-Outschoorn, MD, PhD

Megan.Roche@jefferson.edu

Publications: Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development. Wilde L, Roche M, Domingo-Vidal M, Tanson K, Philp N, Curry J, Martinez-Outschoorn U. Semin Oncol. 2017 Jun;44(3):198-203. doi: 10.1053/j.seminoncol.2017.10.004. Epub 2017 Oct 10. Review. PMID: 29248131

Metformin Effects on Metabolic Coupling and Tumor Growth in Oral Cavity Squamous Cell Carcinoma Coinjection Xenografts. Tassone P, Domingo-Vidal M, Whitaker-Menezes D, Lin Z, Roche M, Tuluc M, Martinez-Outschoorn U, Curry J. Otolaryngol Head Neck Surg. 2018 May;158(5):867-877. doi: 10.1177/0194599817746934. Epub 2017 Dec 12. PMID: 29232177
TIGAR Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. Ko YH, Domingo-Vidal M, Roche M, Lin Z, Whitaker-Menezes D, Seifert E, Capparelli C, Tuluc M, Birbe RC, Tassone P, Curry JM, Navarro-Sabate A, Manzano A, Bartrons R, Caro J, Martinez-Outschoorn U. J Biol Chem. 2016 Nov 1. pii: jbc.M116.740209. [Epub ahead of print] PMID: 27803158


Noor Shaik (MD/PhD)

Noor Shaik (MD/PhD)
Laboratory of Ulhas Naik, PhD

Noor.Shaik@jefferson.edu  

 


Michael Young

Michael Young                                           
Laboratory of Suresh Joseph, PhD

Michael.Young@jefferson.edu

Publications: Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells. Joseph SK, Young MP, Alzayady K, Yule DI, Ali M, Booth DM, Hajnóczky G. J Biol Chem. 2018 Nov 9;293(45):17464-17476. doi: 10.1074/jbc.RA118.005624. Epub 2018 Sep 18. PMID: 30228182

 


Deborah Gorth (MD/PhD)

Deborah Gorth (MD/PhD)
Laboratory of Makarand Risbud, PhD

Deborah.Gorth@jefferson.edu

Publications: Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration.  Gorth DJ, Shapiro IM, Risbud MV. Cell Death Dis. 2018 Dec 18;10(1):7. doi: 10.1038/s41419-018-1246-x. PMID: 30584238


Discovery of the drivers of inflammation induced chronic low back pain: from bacteria to diabetes. Gorth DJ, Shapiro IM, Risbud MV. Discov Med. 2015 Oct;20(110):177-84. PMID: 26562470

Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long-term agarose culture. Gorth DJ, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ. J Orthop Res. 2015 May;33(5):747-54. doi: 10.1002/jor.22821. Epub 2015 Mar 8. PMID: 25640328

In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation. Gorth DJ, Martin JT, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ.

J Exp Orthop. 2014 Dec;1(1):15. doi: 10.1186/s40634-014-0015-8. Epub 2014 Nov 21. PMID: 26914760

In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus. Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Elliott DM, Mauck RL, Chen W, Malhotra NR. Tissue Eng Part A. 2014 Jul;20(13-14):1841-9. doi: 10.1089/ten.TEA.2013.0516. Epub 2014 Mar 21. PMID: 24410394

Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration. Martin JT, Gorth DJ, Beattie EE, Harfe BD, Smith LJ, Elliott DM. J Orthop Res. 2013 Aug;31(8):1276-82. doi: 10.1002/jor.22355. Epub 2013 Apr 1. PMID: 23553925

Decreased bacteria activity on Si₃N₄ surfaces compared with PEEK or titanium. Gorth DJ, Puckett S, Ercan B, Webster TJ, Rahaman M, Bal BS. Int J Nanomedicine. 2012;7:4829-40. doi: 10.2147/IJN.S35190. Epub 2012 Sep 7. PMID: 22973102

IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro. Gorth DJ, Mauck RL, Chiaro JA, Mohanraj B, Hebela NM, Dodge GR, Elliott DM, Smith LJ. Arthritis Res Ther. 2012 Aug 3;14(4):R179. doi: 10.1186/ar3932. PMID: 22863285


Elham Javed

Elham Javed                 
Laboratory of Boopathi Ettickan, PhD

Elham.Javed@jefferson.edu

Publications:  NF-κB and GATA-6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy. Thangavel C, Gomes CM, Zderic SA, Javed E, Addya S, Singh J, Das S, Birbe R, Den RB, Rattan S, Deshpande DA, Penn RB, Chacko S, Boopathi E. Am J Pathol. 2019 Jan 30. pii: S0002-9440(18)30365-1. doi: 10.1016/j.ajpath.2018.12.013. [Epub ahead of print]
PMID: 30707892


Lauren Langbein

Lauren Langbein             
Laboratory of Haifeng Yang, PhD

Lauren.Langbein@jefferson.edu  

Publications: Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. Liao L, Liu ZZ, Langbein L, Cai W, Cho EA, Na J, Niu X, Jiang W, Zhong Z, Cai WL, Jagannathan G, Dulaimi E, Testa JR, Uzzo RG, Wang Y, Stark GR, Sun J, Peiper S, Xu Y, Yan Q, Yang H. Elife. 2018 Oct 25;7. pii: e37925. doi: 10.7554/eLife.37925. PMID: 30355451

High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1. Liao L, Alicea-Velázquez NL, Langbein L, Niu X, Cai W, Cho EA, Zhang M, Greer CB, Yan Q, Cosgrove MS, Yang H. Mol Oncol. 2018 Dec 26. doi: 10.1002/1878-0261.12434. [Epub ahead of print] PMID: 30585695


Emanuel José Magalhães Novais (MD/PhD)

Emanuel José Magalhães Novais (MD/PhD)
Laboratory of Makarand Risbud, PhD

emanueljosenovais@gmail.com

Publications: p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Novais EM, Diekman BO, Shapiro IM, Risbud MV. Matrix Biol. 2019 Feb 24. pii: S0945-053X(18)30464-5. doi: 10.1016/j.matbio.2019.02.004. [Epub ahead of print] PMID: 30811968


Sara Bisetto

Sara Bisetto                                           
Laboratory of Nancy Philp, PhD

Sara.Bisetto@jefferson.edu

Publications: Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA. Loro E, Bisetto S, Khurana TS. J Cell Sci. 2018 Nov 2;131(21). pii: jcs218313. doi: 10.1242/jcs.218313. PMID: 30301784

Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer. Bisetto S, Whitaker-Menezes D, Wilski NA, Tuluc M, Curry J, Zhan T, Snyder CM, Martinez-Outschoorn UE, Philp NJ. Front Oncol. 2018 Aug 28;8:324. doi: 10.3389/fonc.2018.00324. eCollection 2018. PMID: 30211114

 Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell TG, Bisetto S, Velasco-Velázquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, Shen CH, Scherer PE, Pestell RG. Cancer Res. 2017 Jul 1;77(13):3391-3405. doi: 10.1158/0008-5472.CAN-16-0425. Epub 2017 May 18. PMID: 28522753

A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration. Zhang H, Wang P, Bisetto S, Yoon Y, Chen Q, Sheu SS, Wang W.  Cardiovasc Res. 2016 Oct 29. pii: cvw212. [Epub ahead of print] PMID: 27794519

Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity. Rouleau L, Antony AN, Bisetto S, Newberg A, Doria C, Levine M, Monti DA, Hoek JB.  Free Radic Biol Med. 2016 Jun;95:308-22. doi: 10.1016/j.freeradbiomed.2016.03.031. Epub 2016 Mar 30. PMID: 27036367

Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria. Di Sante G, Pestell TG, Casimiro MC, Bisetto S, Powell MJ, Lisanti MP, Cordon-Cardo C, Castillo-Martin M, Bonal DM, Debattisti V, Chen K, Wang L, He X, McBurney MW, Pestell RG. Am J Pathol. 2015 Jan;185(1):266-79. doi: 10.1016/j.ajpath.2014.09.014. PMID: 25529796

Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-α-mediated cardiac inflammatory responses. Pan S, Wang N, Bisetto S, Yi B, Sheu SS.  Am J Physiol Heart Circ Physiol. 2015 Jan 1;308(1):H39-48. doi: 10.1152/ajpheart.00330.2014. Epub 2014 Nov 7. PMID: 25380814

Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, Murayama T, Sheu SS.  Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1736-51. doi: 10.1152/ajpheart.00094.2013. Epub 2013 Oct 11. PMID: 24124188


Elizabeth Silagi

Elizabeth Silagi

Laboratory of Makarand Risbud, PhD

Elizabeth.Silagi@jefferson.edu

Publications: A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. Choi H, Tessier S, Silagi ES, Kyada R, Yousefi F, Pleshko N, Shapiro IM, Risbud MV. Matrix Biol. 2018 Sep;70:102-122. doi: 10.1016/j.matbio.2018.03.019. Epub 2018 Mar 29. PMID: 29605718

Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. Silagi ES, Batista P, Shapiro IM, Risbud MV. Sci Rep. 2018 Mar 20;8(1):4856. doi: 10.1038/s41598-018-23196-7. PMID: 29559661

Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. Silagi, E. S., Schoepflin, Z. R., Seifert, E. L., Merceron, C., Schipani, E., Shapiro, I. M., and Risbud, M. V (2018) J. Bone Miner. Res. 33, 338–355

Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc disease. Silagi, E. S., Shapiro, I. M., and Risbud, M. V. (2018) Matrix Biol. Epub Ahead of Print.

Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia Responsive and Confers Protection from Oxidative Stress-induced Cell Death.  Silagi, E. S., Batista P., Shapiro, I. M., and Risbud, M. V. (2018) Sci Rep. Accepted Mar 7 2018

PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis. Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV. FASEB J. 2017 May 11. pii: fj.201601291R. doi: 10.1096/fj.201601291R. [Epub ahead of print] PMID: 28495754

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV. Oncotarget. 2016 Mar 31. doi: 10.18632/oncotarget.8521. [Epub ahead of print] PMID: 27049729


Victoria Gennaro

Victoria Gennaro 
Laboratory of Steve McMahon, PhD

Victoria.Gennaro@jefferson.edu

Publications: Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells. Gennaro VJ, Stanek TJ, Peck AR, Sun Y, Wang F, Qie S, Knudsen KE, Rui H, Butt T, Diehl JA, McMahon SB. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9298-E9307. doi: 10.1073/pnas.1807704115. Epub 2018 Sep 17. PMID: 30224477

Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, Sharma SD, Martinez-Outschoorn UE, Vakoc CR, Chodosh LA, Thompson JE, Bradner JE, Cameron CE, Shadel GS, Eischen CM, McMahon SB. Oncotarget. 2016 Aug 31. doi: 10.18632/oncotarget.11718. [Epub ahead of print] PMID: 27590350


Stephen Hurst

Stephen Hurst
Laboratory of Shey-Shing Sheu, PhD

Stephen.Hurst@jefferson.edu
 

Publications:  The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology. Mishra J, Jhun BS, Hurst S, O-Uchi J, Csordás G, Sheu SS.  Handb Exp Pharmacol. 2017 Feb 14. doi: 10.1007/164_2017_1. [Epub ahead of print] PMID: 28194521

Mitochondrial Ca2+ and regulation of the permeability transition pore. Hurst S, Hoek J, Sheu SS. J Bioenerg Biomembr. 2016 Aug 6. [Epub ahead of print] Review. PMID: 27497945

Isoform-specific dynamic translocation of PKC by a1-adrenoceptor stimulation in live cells. O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM. Biochem Biophys Res Commun. 2015 Sep 25;465(3):464-70. doi: 10.1016/j.bbrc.2015.08.040. Epub 2015 Aug 12. PMID: 26277396

Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS. Neurosci Lett. 2014 Jul 11;575:7-12. doi: 10.1016/j.neulet.2014.05.026. Epub 2014 May 23. PMID: 24861510

Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS.  Antioxid Redox Signal. 2014 Aug 20;21(6):863-79. doi: 10.1089/ars.2013.5394. Epub 2014 Jun 25.  PMID: 24800979

Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling. O-Uchi J, Ryu SY, Jhun BS, Hurst S, Sheu SS.  Antioxid Redox Signal. 2014 Aug 20;21(6):987-1006. doi: 10.1089/ars.2013.5681. Epub 2014 Feb 3. Review. PMID: 24180309

Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, Murayama T, Sheu SS.  Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1736-51. doi: 10.1152/ajpheart.00094.2013. Epub 2013 Oct 11. PMID: 24124188

Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor. O-Uchi J, Komukai K, Kusakari Y, Morimoto S, Kawai M, Jhun BS, Hurst S, Hongo K, Sheu SS, Kurihara S.  Biochem Biophys Res Commun. 2013 Apr 5;433(2):188-93. doi: 10.1016/j.bbrc.2013.02.072. Epub 2013 Feb 27. PMID: 23454381

Using clinical simulation centers to test design interventions: a pilot study of lighting and color modifications. Gray WA, Kesten KS, Hurst S, Day TD, Anderko L. HERD. 2012 Spring;5(3):46-65. PMID: 23002568

Medical simulation technology: educational overview, industry leaders, and what's missing. Spooner N, Hurst S, Khadra M. Hosp Top. 2012 Jul-Sep;90(3):57-64. PMID: 22989223

Recent Graduates

2018/2019

Frederick (Eric) Arnold III

Frederick (Eric) Arnold III                                   
Laboratory of Diane Merry, PhD
Now: Duke University, Durham, NC

Frederick.ArnoldIII@jefferson.edu

Publications: Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. Arnold FJ, Pluciennik A, Merry DE. Sci Rep. 2019 Jan 15;9(1):119. doi: 10.1038/s41598-018-36784-4. PMID: 30644418

 


Hyowon Choi (MD/PhD)

Hyowon Choi (MD/PhD)
Laboratory of Makarand Risbud, PhD
Now: Medical Student at Sidney Kimmel Medical College

Hyowon.Choi@jefferson.edu

Publications: COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus Cells.  Choi H, Chaiyamongkol W, Doolittle AC, Johnson ZI, Gogate SS, Schoepflin ZR, Shapiro IM, Risbud MV.  J. Biol Chem. 2018; April 26 (Accepted)

A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis.    Choi H, Tessier S, Silagi ES, Kyada R, Yousefi F, Pleshko N, Shapiro IM, Risbud MV.  Matrix Biology

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus.  Liu, C.*, Choi, H.*, Johnson, Z.I., Tian, J., Shapiro, I.M., Risbud, M.V. Sci Rep. 2017 Jul 3;7(1):4543. doi: 10.1038/s41598-017-04876-2.  PMID: 28674405

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Autophagy. 2016 Sep;12(9):1631-46. doi: 10.1080/15548627.2016.1192753. PMID: 27314664

N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Hwang PY, Jing L, Chen J, Lim FL, Tang R, Choi H, Cheung KM, Risbud MV, Gersbach CA, Guilak F, Leung VY, Setton LA. Sci Rep. 2016 Jun 13;6:28038. doi: 10.1038/srep28038. PMID: 27292569

Circadian factors BMAL1 and RORa control HIF-1a transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV.  Oncotarget. 2016 Mar 31. doi: 10.18632/oncotarget.8521. [Epub ahead of print] PMID: 27049729

Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Choi H, Johnson ZI, Risbud MV. Curr Stem Cell Res Ther. 2015;10(4):307-16. Review. PMID: 25584906


Aditi Swarup

Aditi Swarup                                             
Laboratory of Nancy Philp, PhD
Now: Stanford University, San Francisco, CA

Aditi.Swarup@jefferson.edu

Publications: Loss of MPC1 reprograms retinal metabolism to impair visual function. Grenell A, Wang Y, Yam M, Swarup A, Dilan TL, Hauer A, Linton JD, Philp NJ, Gregor E, Zhu S, Shi Q, Murphy J, Guan T, Lohner D, Kolandaivelu S, Ramamurthy V, Goldberg AFX, Hurley JB, Du J. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3530-3535. doi: 10.1073/pnas.1812941116. Epub 2019 Feb 11. PMID: 30808746

Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells.
Swarup A
, Samuels IS, Bell BA, Han JYS, Du J, Massenzio E, Abel ED, Boesze-Battaglia K, Peachey NS, Philp NJ. Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C121-C133. doi: 10.1152/ajpcell.00410.2018. Epub 2018 Nov 21. PMID: 30462537

Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Aditi Swarup, Brent A. Bell, John Y. S. Han, Jamie Soto, E. Dale Abel, Arturo Bravo-Nuevo, Paul G. FitzGerald, Neal S. Peachey Nancy J. PhilpDepartment of Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA. Experimental Eye Res.

Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats. Juskeviciute E, Dippold RP, Antony AN, Swarup A, Vadigepalli R, Hoek JB. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G794-G806. doi: 10.1152/ajpgi.00292.2016. PMID: 27634014

Adiponectin fine-tuning of liver regeneration dynamics revealed through cellular network modelling. Correnti JM, Cook D, Aksamitiene E, Swarup A, Ogunnaike B, Vadigepalli R, Hoek JB. J Physiol. 2015 Jan 15;593(2):365-83. doi: 10.1113/jphysiol.2014.284109. PMID: 25630259

Adiponectin fine-tuning of liver regeneration dynamics revealed through cellular network modeling. Correnti JM, Cook D, Aksamitiene E, Swarup A, Ogunnaike B, Vadigepalli R, Hoek JB. J Physiol. 2014 Nov 10. [Epub ahead of print] PMID: 25384784

Metabolic network reconstruction, growth characterization and 13C-metabolic flux analysis of the extremophile Thermus thermophilus HB8. Swarup A, Lu J, DeWoody KC, Antoniewicz MR. Metab Eng. 2014 Jul;24:173-80. doi: 10.1016/j.ymben.2014.05.013. Epub 2014 Jun 5. PMID: 24909362

Pharmacological ceramide reduction alleviates alcohol-induced steatosis and hepatomegaly in adiponectin knockout mice. Correnti JM, Juskeviciute E, Swarup A, Hoek JB. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G959-73. doi: 10.1152/ajpgi.00395.2013. Epub 2014 Apr 17. PMID: 24742988

 


Michael Vido (MD/PhD)

Michael Vido (MD/PhD)
Laboratory of Andrew Aplin, PhD
Now: Medical Student at Sidney Kimmel Medical College

Michael.Vido@jefferson.edu

Publications:
αC IN, αC OUT-that's what it's all about. Hartsough EJ, Vido MJ. Pigment Cell Melanoma Res. 2016 Nov 1. doi: 10.1111/pcmr.12549. [Epub ahead of print] No abstract available. PMID: 27801548

The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma. Boregowda RK, Medina DJ, Markert E, Bryan MA, Chen W, Chen S, Rabkin A, Vido MJ, Gunderson SI, Chekmareva M, Foran DJ, Lasfar A, Goydos JS, Cohen-Solal KA. Oncotarget. 2016 Apr 18. doi: 10.18632/oncotarget.8822. [Epub ahead of print] PMID: 27102439

The Broad Stroke of Hsp90 Inhibitors: Painting over the RAF Inhibitor Paradox. Vido MJ, Aplin AE.  J Invest Dermatol. 2015 Oct;135(10):2355-7. doi: 10.1038/jid.2015.239. PMID: 26358385


2017/2018

Velina Atanasova

Velina Atanasova                                
Laboratory of Jouni Uitto, MD

Velina.Atanasova@jefferson.edu

Publications: Seven novel COL7A1 mutations identified in patients with recessive dystrophic epidermolysis bullosa from Mexico.  Saeidian AH, Youssefian L, Moreno Trevino MG, Fortuna G, Vahidnezhad H, Atanasova VS, Uitto J, Salas-Alanis JC2, South AP. Clin Exp Dermatol. 2018 Feb 23. doi: 10.1111/ced.13407. [Epub ahead of print]

First report of COL7A1 mutations in two patients with recessive dystrophic epidermolysis bullosa from Peru. Saeidian AH, Youssefian L, Rosales-Solis GM, Vahidnezhad H, Atanasova VS, Uitto J, South AP, Salas-Alanis JC. Clin Exp Dermatol. 2018 Feb 9. doi: 10.1111/ced.13400. [Epub ahead of print]

Amlexanox enhances premature termination codon read-through in COL7A1 and expression of full length type VII collagen: potential therapy for recessive dystrophic epidermolysis bullosa. Atanasova VS, Jiang Q, Prisco M, Gruber C, Piñón Hofbauer J, Chen M, Has C, Bruckner-Tuderman L, McGrath JA, Uitto J, South AP. J Invest Dermatol. 2017 May 23. pii: S0022-202X(17)31550-6. doi: 10.1016/j.jid.2017.05.011. [Epub ahead of print] PMID: 28549954

 


2016/2017

Maria Gubbiotti (MD/PhD)

Maria Gubbiotti (MD/PhD)
Laboratory of Renato Iozzo, MD
Now: Medical Student at Sidney Kimmel Medical College

Maria.Gubbiotti@jefferson.edu

Publications: Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. Schaefer L, Tredup C, Gubbiotti MA, Iozzo RV. FEBS J. 2017 Jan;284(1):10-26. doi: 10.1111/febs.13963. Review. PMID: 27860287

Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions. Gubbiotti MA, Vallet SD, Ricard-Blum S, Iozzo RV. Matrix Biol. 2016 Sep;55:7-21. doi:10.1016/j.matbio.2016.09.009. Review. PMID: 27693454

A current view of perlecan in physiology and pathology: A mosaic of functions. Gubbiotti MA, Neill T, Iozzo RV.  Matrix Biol. 2016 Sep 6. pii: S0945-053X(16)30182-2. doi: 10.1016/j.matbio.2016.09.003. [Epub ahead of print] Review. PMID: 27613501

Endorepellin-evoked autophagy contributes to angiostasis. Goyal A, Gubbiotti MA, Chery DR, Han L, Iozzo RV.  J Biol Chem. 2016 Jul 19. pii: jbc.M116.740266. [Epub ahead of print] PMID: 27435676

Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept. Gubbiotti MA, Iozzo RV.  Matrix Biol. 2015 Oct;48:6-13. doi: 10.1016/j.matbio.2015.10.002. Epub 2015 Oct 14. No abstract available. PMID: 26462577

Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy. Gubbiotti MA, Neill T, Frey H, Schaefer L, Iozzo RV.  Matrix Biol. 2015 Oct;48:14-25. doi: 10.1016/j.matbio.2015.09.001. Epub 2015 Sep 4. PMID: 26344480

An improved phenylarsine oxide-affinity method identifies triose phosphate isomerase as a candidate redox receptor protein. Foley TD, Stredny CM, Coppa TM, Gubbiotti MA.  Neurochem Res. 2010 Feb;35(2):306-14. doi: 10.1007/s11064-009-0056-z. PMID: 19731017


Caitlin Logan (MD/PhD)

Caitlin Logan (MD/PhD)
Laboratory of Sue Menko, PhD
Now: Medical Student at Sidney Kimmel Medical College

Caitlin.Logan@jefferson.edu

Publications: Induction of Immune Surveillance of the Dysmorphogenic Lens.
Logan CM, Bowen CJ, Menko AS. Sci Rep. 2017 Nov 24;7(1):16235. doi: 10.1038/s41598-017-16456-5. PMID: 29176738

Functional role for stable microtubules in lens fiber cell elongation.
Logan CM, Bowen CJ, Menko AS. Exp Cell Res. 2018 Jan 15;362(2):477-488. doi: 10.1016/j.yexcr.2017.12.012. Epub 2017 Dec 15. PMID: 29253534

N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis.  Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS.  Dev Biol. 2017 Aug 1;428(1):118-134. doi: 10.1016/j.ydbio.2017.05.022. Epub 2017 May 26. PMID: 28552735


Zariel Johnson
Laboratory of Makarand Risbud, PhD
Now: Project Manager at UPMC

Zariel.Johnson@jefferson.edu

Publications:

TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells.
Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL, Risbud MV. J Biol Chem. 2017 Oct 20;292(42):17561-17575. doi: 10.1074/jbc.M117.790378. Epub 2017 Aug 25. PMID: 28842479

RNA sequencing reveals a role of TonEBP in regulation of pro-inflammatory genes in response to hyperosmolarity in healthy nucleus pulposus cells: A homeostatic response? Johnson ZI, Shapiro IM, Risbud MV. J Biol Chem. 2016 Nov 8. pii: jbc.M116.757732. [Epub ahead of print] PMID: 27875309

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells. Johnson ZI, Gogate SS, Day R, Binch A, Markova DZ, Chiverton N, Cole A, Conner M, Shapiro IM, Le Maitre CL, Risbud MV. Oncotarget. 2015 May 20;6(14):11945-58. PMID: 25844601

Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Choi H, Johnson ZI, Risbud MV. Curr Stem Cell Res Ther. 2015;10(4):307-16. Review. PMID: 25584906

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP. Johnson ZI, Shapiro IM, Risbud MV. Matrix Biol. 2014 Nov;40:10-6. doi: 10.1016/j.matbio.2014.08.014. Epub 2014 Aug 27. Review. PMID: 25172826

FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PMID: 24867948


Christopher McNair
Laboratory of Karen Knudsen, PhD
Now: Computational Biologist at the SKCC

Christopher.McNair@jefferson.edu

Publications:

Differential impact of RB status on E2F1 reprogramming in human cancer.
McNair C, Xu K, Mandigo AC, Benelli M, Leiby B, Rodrigues D, Lindberg J, Gronberg H, Crespo M, De Laere B, Dirix L, Visakorpi T, Li F, Feng FY, de Bono J, Demichelis F, Rubin MA, Brown M, Knudsen KE. J Clin Invest. 2018 Jan 2;128(1):341-358. doi: 10.1172/JCI93566. Epub 2017 Dec 4.
PMID: 29202480

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE. Cancer Cell. 2015 Jul 13;28(1):97-113. doi:10.1016/j.ccell.2015.06.004. PMID: 26175416

Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes.

Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, Jernigan DL, Dean JL, Fatatis A, McDonnell DP, Visakorpi T, Feng FY, Knudsen KE. J Clin Invest. 2013 Jan;123(1):493-508. doi: 10.1172/JCI64750. Epub 2012 Dec 21. PMID: 23257359

Effects of estrogen on the neuromuscular system in the embryonic zebrafish (Danio rerio). Houser A, McNair C, Piccinini R, Luxhoj A, Bell WE, Turner JE. Brain Res. 2011 Mar 24;1381:106-16. doi: 10.1016/j.brainres.2011.01.033. Epub 2011 Jan 19. PMID: 21255558


Anil Antony, PhD
Laboratory of Joannes Hoek, PhD
Now: Post-Doc in Dr. Joannes Hoek’s Laboratory

Anil.Antony@jefferson.edu

Publications:

MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Antony AN, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, Rubin E, Csordás G, Seifert EL, Hoek JB, Hajnóczky G. Nat Commun. 2016 Mar 9;7:10955. doi: 10.1038/ncomms10955. PMID: 26956930

Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats. Juskeviciute E, Dippold RP, Antony AN, Swarup A, Vadigepalli R, Hoek JB. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G794-G806. doi: 10.1152/ajpgi.00292.2016. PMID: 27634014

Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity. Rouleau L, Antony AN, Bisetto S, Newberg A, Doria C, Levine M, Monti DA, Hoek JB.  Free Radic Biol Med. 2016 Jun;95:308-22. doi: 10.1016/j.freeradbiomed.2016.03.031. Epub 2016 Mar 30.


Annabel Torres, PhD
Laboratory of Renato Iozzo, MD, PhD
Now: Post-Doc at CHOP

Publications:

Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. Torres A, Gubbiotti MA, Iozzo RV.
J Biol Chem. 2017 Mar 24;292(12):5055-5069. doi: 10.1074/jbc.M116.753632. Epub 2017 Feb 7. PMID: 28174297

Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin.
Neill T, Torres A, Buraschi S, Owens RT, Hoek JB, Baffa R, Iozzo RV. J Biol Chem. 2014 Feb 21;289(8):4952-68. doi: 10.1074/jbc.M113.512566. Epub 2014 Jan 8. PMID: 24403067

Decorin has an appetite for endothelial cell autophagy.
Neill T, Torres A, Buraschi S, Iozzo RV. Autophagy. 2013 Oct;9(10):1626-8. doi: 10.4161/auto.25881. Epub 2013 Aug 13. Review. PMID: 23989617

Decorin causes autophagy in endothelial cells via Peg3.
Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens RT, Schaefer L, Torres A, Iozzo RV. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2582-91. doi: 10.1073/pnas.1305732110. Epub 2013 Jun 24. PMID: 23798385


Gregory Omerza, PhD
Laboratory of Edward Winter, PhD
Now:  Clinical Research Coordinator IV at Jefferson

Gregory.Omerza@jefferson.edu

Publications:

The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. Omerza G, Tio CW, Philips T, Diamond A, Neiman AM, Winter E. Mol Biol Cell. 2018 Jan 1;29(1):66-74. doi: 10.1091/mbc.E17-07-0473. Epub 2017 Nov 8. PMID: 29118076  

Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase. Tio CW, Omerza G, Phillips T, Lou HJ, Turk BE, Winter E. Mol Cell Biol. 2017 May 2;37(10). pii: e00607-16. doi: 10.1128/MCB.00607-16. Print 2017 May 15. PMID: 28223369  

Autophosphorylation of the Smk1 MAPK is spatially and temporally regulated by Ssp2 during meiotic development in yeast. Tio CW, Omerza G, Sunder S, Winter E. Mol Biol Cell. 2015 Oct 1;26(19):3546-55. doi: 10.1091/mbc.E15-05-0322. Epub 2015 Aug 5. PMID: 26246597  

Activation of the Smk1 mitogen-activated protein kinase by developmentally regulated autophosphorylation. Whinston E, Omerza G, Singh A, Tio CW, Winter E. Mol Cell Biol. 2013 Feb;33(4):688-700. doi: 10.1128/MCB.00973-12. Epub 2012 Dec 3. PMID: 23207907