Philadelphia University + Thomas Jefferson University

Chalfin, Donald

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Donald B. Chalfin, MD, MS, MPH, FCCP, FCCM

Donald B. Chalfin, MD, MS, MPH, FCCP, FCCM

Contact Dr. Chalfin

901 Walnut Street
10th Floor
Philadelphia, PA 19107

(215) 503-0174
(215) 923-7583 fax


MD, Mount Sinai School of Medicine
MS, New York University
MPH, Johns Hopkins University
BA, University of Pennsylvania


Internal Medicine, Long Island Jewish Medical Center


Heyward Fellowship, Memorial Sloan-Kettering Cancer Center

Board Certification

Critical Care Medicine
Internal Medicine

University Appointments

Lecturer, Jefferson College of Population Health

Research & Practice Interests

Critical Care Medicine
Hospice and Palliative Care
Internal Medicine
Health Economics and Outcomes Research


Economic Modeling in Healthcare


Dr. Donald Chalfin is Vice President of Medical Affairs at Astute Medical in San Diego, CA. He is the author of several articles and book chapters on cost-effectiveness analysis, the application of economic methods in clinical medicine, decision analysis, neural network analysis, artificial intelligence and outcomes assessment and predictive models. Dr. Chalfin earned his MD from the Mount Sinai School of Medicine, his MPH from the Johns Hopkins Bloomberg School of Public Health and his MS in Health Management and Health Economics from the Robert F Wagner Graduate School of Public Service at New York University.


Most Recent Peer-Reviewed Publications

  1. Cost-effectiveness of three different strategies for the treatment of first recurrent Clostridium difficile infection diagnosed in a community setting
  2. The critical care physician and a career in industry: Reflections and recommendations
  3. Simulation-based training for emergency medicine residents in sterile technique during central venous catheterization: Impact on performance, policy, and outcomes
  4. Rapid diagnosis of infection in the critically ill, a multicenter study of molecular detection in bloodstream infections, pneumonia, and sterile site infections
  5. Cost-effectiveness of a FISH assay for the diagnosis of melanoma in the USA
  6. Economics of cancer biomarkers
  7. Reflections on the demand for critical care in the global medical village
  8. Health Economics and Critical Care
  9. Cost-effectiveness of a fourth-generation combination immunoassay for human immunodeficiency virus (HIV) antibody and p24 antigen for the detection of HIV infections in the United States
  10. The economic impact and cost-effectiveness of urinary neutrophil gelatinase-associated lipocalin after cardiac surgery
  11. In response
  12. Association between critical care physician management and patient mortality in the intensive care unit
  13. Prioritizing the organization and management of intensive care services in the United States: The PrOMIS Conference
  14. Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit
  15. Falling towers, crumbling levees, and viral mutations
  16. Length of intensive care unit stay and patient outcome: The long and short of it all
  17. Physician and nurse satisfaction with an Electronic Medical Record system
  18. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 Update
  19. Implementation of standards for intensivist staffing: Is it time to jump aboard the Leapfrog bandwagon?
  20. The critical care crisis in the United States: A report from the profession