Philadelphia University + Thomas Jefferson University

Rothman, Margaret

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Margaret L. Rothman, PhD, MN

Contact Dr. Rothman

901 Walnut Street
10th Floor
Philadelphia, PA 19107

(215) 503-0174
(215) 923-7583 fax


PhD, University of Washington
MN, University of Washington
BSN, University Of Maryland, Baltimore
BA, University of Maryland, College Park

University Appointments

Lecturer, Jefferson College of Population Health

Research & Practice Interests

Assessment of Subjective Health Outcomes
Clinical Development
Clinical Research
Outcomes Research
Health Economics 


Subjective Outcomes in Health Evaluation


Dr. Margaret Rothman is CEO of Rothman Associates, which specializes in clinical outcomes assessment in all types of studies. Currently, she is a lecturer at the Thomas Jefferson University College of Population Health, teaching Subjective Outcomes in Health Evaluation in the Applied Health Economics & Outcomes Research program. Dr. Rothman earned her PhD in Measurement, Statistics and Research Design at the University of Washington.  


Most Recent Peer-Reviewed Publications

  1. Patient-reported Outcomes for Multicentric Castleman’s Disease in a Randomized, Placebo-controlled Study of Siltuximab
  2. Can we use social media to support content validity of patient-reported outcome instruments in medical product development?
  3. Siltuximab for multicentric Castleman's disease: A randomised, double-blind, placebo-controlled trial
  4. Effect of abiraterone acetate on fatigue in patients with metastatic castration-resistant prostate cancer after docetaxel chemotherapy
  5. Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: Exploratory analysis of data from the COU-AA-301 randomised trial
  6. Validation of a bowel function diary for assessing opioid-induced constipation
  7. Efficacy and Safety of Dapoxetine for the Treatment of Premature Ejaculation: Integrated Analysis of Results from Five Phase 3 Trials
  8. Measuring social functioning with the personal and social performance scale in patients with acute symptoms of schizophrenia: Interpretation of results of a pooled analysis of three Phase III trials of paliperidone extended-release tablets
  9. Validity of the patient-reported clinical global impression of change as a measure of treatment response in men with premature ejaculation
  10. Treatment of premature ejaculation in the Asia-Pacific Region: Results from a phase III double-blind, parallel-group study of dapoxetine
  11. Comments on "considerations for an evidence-based definition of premature ejaculation in the DSM-V"
  12. Independent effect of paliperidone extended release on social functioning beyond its effect on positive and negative symptoms of schizophrenia: A mediation analysis
  13. Using the patient global assessment of the method of pain control to assess new analgesic modalities in clinical trials
  14. Dapoxetine for the Treatment of Premature Ejaculation: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial in 22 Countries
  15. The Premature Ejaculation Profile: Validation of self-reported outcome measures for research and practice
  16. Reliability, validity and ability to detect change of the clinician-rated Personal and Social Performance scale in patients with acute symptoms of schizophrenia
  17. Use of existing patient-reported outcome (PRO) instruments and their modification: The ISPOR good research practices for evaluating and documenting content validity for the use of existing instruments and their modification PRO task force report
  18. Analyzing multiple endpoints in clinical trials of pain treatments: IMMPACT recommendations
  19. Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: Results from phase III trials with dapoxetine
  20. Characterizing the burden of premature ejaculation from a patient and partner perspective: A multi-country qualitative analysis