The Laboratory of Dr. Renato V. Iozzo is the world-leader in proteoglycan research, focusing on the coordinated regulation of tumorigenesis, angiogenesis, and autophagy. Specifically, we study the roles of decorin and perlecan, particularly the C-terminal fragment known as endorepellin, in regulating these fundamental processes by evaluating diverse in vitro systems and novel in vivo models. We also study the pleiotropic growth factor, progranulin. Importantly, we have recently discovered that EphA2 is a functional signaling receptor for progranulin. We are currently investigating the role of progranulin / EphA2 in prostate and bladder cancer models.
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