The eXtraordinarY Babies Study:
Natural History of Health & Neuro-development in Infants and Young Children with Sex Chromosome Trisomy.
NIH/NICHD 1R01HD091251-01 (PI: Tartaglia, co-I: Ross) 9/06/2017–06/30/2022. The aims are to describe the natural history of young children with sex chromosome trisomy from infancy to 5 years, with a focus on early predictors of neurodevelopmental and cardiometabolic outcomes.
Mean Diffusivity (MD)
Legend - Figure 1. Elevated Mean diffusivity (MD) of the left arcuate fasciculus (AF) in XYY+ASD cohort (TJU left), analogous to those observed in idiopathic ASD (CHOP, right) [Click for larger image]
Neural Correlates of the Y Chromosome in Autism:
XYY Syndrome as a Genetic Model
Department of Defense Idea Research Grant Proposal # AR140197 (MPI: T.Roberts, J. Ross, 7/1/15-6/30/18): This study evaluates similarities in autism features of boys with XYY syndrome versus idiopathic autism.
Neuroimaging in ASD Populations
R21 MH109158-01A1 (MPI: T. Roberts, J. Ross, 04/01/16-3/31/18) "Structural and Functional Characteristics of XYY - Relationship to ASD." This study evaluates potential neuroimaging biomarkers for autism in populations with autism spectrum disorder.
Increased WM and GM in boys with XYY
Legend - Figure 2. Increased WM and GM in boys with XYY versus typically developing boys (frontal, parietal-occipital, temporal cortices)
The IDeA States Pediatric Clinical Trials Network
NIH/NICHD 1UG1HD090915-01 (PI: J.Ross) Delaware Nemours/duPont Hospital for Children Site for the IDeA States Pediatric Clinical Trials Network, 9/21/16-8/31/20. The IDeA States Pediatric Clinical Trials Network functions as one component of the overall Environmental influences on Child Health Outcomes (ECHO) Program.
Center for Pediatric Research
NIH/NIGMS 1P30GM114736-01 (PI: T Shaffer, co-I: J Ross)
(CPR) 08/01/2015 – 07/31/2020. Project goals for this Center of Biologic Research Excellence (COBRE) study include development of pediatric translational research programs.