The rabies virus virion. Nature Reviews Microbiology 8, 51-61 (2010)
While viruses are the source of many infectious diseases, they can also be harnessed to combat disease. For example, viral vectors are excellent tools for producing vaccines against infectious diseases. The major goal of our lab is to develop such vaccines based on highly attenuated rabies and measles viruses. Several vaccines are in preclinical development with some approaching clinical testing.
In addition to producing vaccines, we are pursuing a detailed understanding of the biochemistry, molecular biology and immunology of the rabies virus and its interaction with the infected host. We also use the rabies virus as a tool for studying neuroanatomy.
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