Thomas Jefferson University


Highlighted Publications

Walsh PD, Kurup D, Hasselschwert DL, Wirblich C, Goetzmann JE, Schnell MJ. The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees? Sci Rep. 2017;7:43339. doi: 10.1038/srep43339. PubMed.

In this study, we showed that apes can be orally immunized against rabies virus and Ebola virus. Ebola virus is not only a killer of humans but also kills the endangered great apes and protection is urgently needed.

Johnson RF, Kurup D, Hagen KR, Fisher C, Keshwara R, Papaneri A, Perry DL, Cooper K, Jahrling PB, Wang JT, Ter Meulen J, Wirblich C, Schnell MJ. An Inactivated Rabies Virus-Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models. The Journal of infectious diseases. 2016;214(suppl 3):S342-S54. doi: 10.1093/infdis/jiw231. PubMed

This publication provides evidence that a deactivated rabies virus-based vaccine protects against Ebola virus in non-human primates. The deactivated vaccine is currently being further developed and will soon move in phase 1 clinical trials in humans.

Reardon TR, Murray AJ, Turi GF, Wirblich C, Croce KR, Schnell MJ, Jessell TM, Losonczy A. Rabies Virus CVS-N2c Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability. Neuron. 2016.

Rabies virus naturally infects neurons and can therefore be manipulated into is an excellent tracing tool to analyze neuroanatomy and neuronal connections.

Pfaller CK, Cattaneo R, Schnell MJ. Reverse genetics of Mononegavirales: How they work, new vaccines, and new cancer therapeutics. Virology. 2015;479-480:331-44.

This publication provides a comprehensive overview of the use of mononegavirales virus-based viral vectors, a major interest of our laboratory.

Davis BD, Rall GF, Schnell MJ. Everything you always wanted to know about rabies virus (but were afraid to ask). In: Enquist D, DiMaio, editor. Annual Review of Virology. Palo Alto, California, USA: Annual Reviews; 2015. p. 51-71.

This article gives an overview of the rabies virus, the molecular virology of which is the foundational expertise of our lab.

Recent Publications

Rabies virus (RV) glycoprotein expression levels are not critical for pathogenicity of RV

Dendritic cells infected by recombinant rabies virus vaccine vector expressing HIV-1 Gag are immunogenic even in the presence of vector-specific immunity

Induction of neutralizing antibody responses to anthrax protective antigen by using influenza virus vectors: Implications for disparate immune system priming pathways

Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling

Characterization of a single-cycle rabies virus-based vaccine vector

A novel composite immunotoxin that suppresses rabies virus production by the infected cells

Attenuation of rabies virulence: Takeover by the cytoplasmic domain of its envelope protein

The cell biology of rabies virus: Using stealth to reach the brain

Rabies virus-based vaccines elicit neutralizing antibodies, poly-functional CD8+ T cell, and protect rhesus macaques from AIDS-like disease after SIVmac251 challenge

Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates

Intravenous inoculation of a bat-associated rabies virus causes lethal encephalopathy in mice through invasion of the brain via neurosecretory hypothalamic fibers

Lineage-specific T-cell responses to Cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease

Interferon-β expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity

Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene

PPEY motif within the Rabies Virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity

Concepts in the pathogenesis of rabies

Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity

Role of virus-induced neuropeptides in the brain in the pathogenesis of rabies

Cluster formation and rheology of photoreactive nanoparticle dispersions

The glycoprotein and the matrix protein of rabies virus affect pathogenicity by regulating viral replication and facilitating cell-to-cell spread