Philadelphia University + Thomas Jefferson University

Smeyne Laboratory



The Smeyne lab is interested in the cell biology of Parkinson’s disease, focusing on mechanisms of neurodegeneration as well as neuroprotection. Research projects examine the role of viruses in the etiology of Parkinson’s disease, the interactions of the adaptive and humoral immune systems with the innate immune system in the CNS, role of environmental toxins in experimental parkinsonism, the role of LRRK2 and alpha-synuclein as modifiers of disease progression in animal models.  Our lab is also interested in mechanisms that underlie exercise-induced neuroprotection.  Outside of our studies in Parkinson’s disease we are examining the effects of social isolation in adults on neuronal structure and function; as this is a growing problem facing our aging population and also has implications within our criminal justice system.


Richard J. Smeyne, PhD

Contact Dr. Smeyne

900 Walnut Street
444 JHN
Philadelphia, PA 19107

(215) 955- 8634