Philadelphia University + Thomas Jefferson University

Snook Laboratory

Snook Laboratory


We study basic, translational, and clinical aspects of gastrointestinal biology and tumorigenesis. Our research projects focus on the intestinal receptor guanylyl cyclase C (GUCY2C or GCC) and its hormone ligands guanylin and uroguanylin. We have identified this hormone-receptor signaling axis as a critical pathway in intestinal homeostasis, tumor suppression and enteroendocrine signaling. We have translated those discoveries into Phase I chemoprevention studies determining the potential ability of GUCY2C hormones to prevent colorectal cancer. Moreover, we are developing novel cancer immunotherapeutics targeting GUCY2C, including vaccines and CAR-T cells. These immunotherapies could be used to treat metastatic colorectal cancer, as well as esophageal, gastric, and pancreatic cancers, which often overexpress GUCY2C.



Adam Snook, PhD
Research Instructor

Contact Dr. Snook
Lab Website


1020 Locust Street
Room 368
Philadelphia, PA 19107

(215) 503-7445