Thomas Jefferson University
Sidney Kimmel Medical College
Department of Dermatology & Cutaneous Biology

Rodeck, Ulrich

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Ulrich Rodeck, MD, PhD

Contact Dr. Rodeck

Bluemle Life Sciences Building, Room 409
233 South Tenth Street
Philadelphia, PA 19107

(215) 503-5622
(215) 503-5788 fax

Keywords

Cancer Biology; Dermatology; Extracellular Matrix; Receptor Tyrosine Kinases; Signal Transduction; Apoptosis; Zebrafish Model System; Cell Stress Response

Expertise & Research Interests

Work in the Rodeck lab seeks to improve current approaches to cancer therapy with a focus on the interface between tumor biology and the host immune system.  Current projects explore how immunotherapeutic agents (vaccines, checkpoint inhibitors) may be combined with each other or with conventional treatment modalities (for example ionizing radiation and/or targeted agents) to enhance anti-tumor effects. Functional studies are pursued to understand mechanisms of cooperativity encompassing elements of both, innate and adaptive immune responses.  This work is conducted using syngenic mouse tumor models (squamous cell carcinoma, prostate cancer) and human cells and tissues obtained through clinical trials.

Publications

Most Recent Peer-Reviewed Publications

  1. Metformin Effects on FOXP3+ and CD8+ T Cell Infiltrates of Head and Neck Squamous Cell Carcinoma
  2. Is host metabolism the missing link to improving cancer outcomes?
  3. Effect of Hypercapnia, an Element of Obstructive Respiratory Disorder, on Pancreatic Cancer Chemoresistance and Progression
  4. A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation
  5. Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis
  6. miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas
  7. Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin
  8. Prognostic Significance of Tumor-Associated Macrophage Content in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis
  9. Loss of CD169+ Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma
  10. Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth
  11. Metformin clinical trial in HPV+ and HPV-head and neck squamous cell carcinoma: Impact on cancer cell apoptosis and immune infiltrate
  12. Listeria monocytogenes as a vector for cancer immunotherapy: Current understanding and progress
  13. STAT5A/B blockade sensitizes prostate cancer to radiation through inhibition of RAD51 and DNA repair
  14. Growth regulation in normal and malignant melanocytes
  15. Global mapping of transcription factor motifs in human aging
  16. Tumor Metabolism in the Microenvironment of Nodal Metastasis in Oral Squamous Cell Carcinoma
  17. Distinct cell stress responses induced by ATP restriction in quiescent human fibroblasts
  18. β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
  19. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
  20. The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice
  21. Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound
  22. Immunotargeting and eradication of orthotopic melanoma using a chemokine-enhanced DNA vaccine
  23. Skinflammation and drug toxicity-A delicate balance
  24. Skin toxicity of targeted cancer agents: Mechanisms and intervention
  25. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells