Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Rattan, Satish

< Back



Satish C. Rattan, DVM

Contact Dr. Rattan

1025 Walnut Street
College Building, Room 320
Philadelphia, PA 19107

(215) 955-5614
(215) 955-5553 fax

Medical School

DVM, Punjab Agricultural University, Hissar, India - 1968
MS, Pharmacology, University of Houston, TX - 1970


Baylor College of Medicine, Houston, TX
University of Texas, South Western Medical School, Dallas, TX


Professor, Medicine, Thomas Jefferson Univ., Philadelphia, PA, 1989- present
Associate Professor
, Harvard Medical School, Boston, MA, 1988-89
Assistant Professor, Harvard Medical School, Boston, MA, 1981-87
Assistant Professor
, University of Texas Health Science Center, San Antonio, TX, 1978-81

Honors & Awards

Council of Indian Organizations Award for Professional & Academic Excellence, 2006
Janssen Award, for Basic Research in Gastroenterology, 1997
Merit Scholarship, Punjab Agricultural University, Hissar, India, 1964-68

Editorial Board

Journal of Pharmacology & Experimental Therapeutics, 1992-99
American Journal of Physiology, 2010-
American Journal of Physiology, 1992-98
Associate Editor GASTROENTEROLOGY, 1986-89

Other Experience & Professional Experience

Teaching Physiology/Pharmacology to Medical Students, 1978-2002
Chief Org. and Director of Am. Motility Society Meeting, Philadelphia, PA, 1998
Member Appointments and Promotions Committee, Thomas Jefferson University, 2000-present
Member Inst. Animal Care & Use Committee, Thomas Jefferson University, 2004-2008
Member, NIH Study Section, 2003
Member, NIH Study Section, 2013
Member, NIH Study Ssection, 2016

Expertise & Research Interests

Dr. Rattan is internationally recognized as an outstanding educator and researcher. He is frequently invited as a visiting Professor. Dr. Rattan has received multiple National and International awards in research and teaching.

In 1997, he received a prestigious Janssen Award for his outstanding basic research in Gastroenterology.

In 2006, he was honored by the Council of Indian Organizations as an outstanding professional.

Dr. Rattan's research has been continuously funded by the National Institutes of Health.

He has been an Associate Editor of GASTROENTEROLOGY, on editorial board of, and a reviewer for a number of prestigious journals.

Research Interest: Disorders of the internal anal sphincter (IAS) underlie many clinical abnormalities, such as fecal incontinence and constipation, hemorrhoids and anal fissures. Such disorders are of particular importance in the growing population of the elderly. The focus of Dr. Rattan's research has been on: 1. the nature and role of inhibitory neurotransmitters and mediators; 2. the neural pathways in the rectoanal inhibitory reflex; and 3. the molecular bases underlying myogenic tone in the IAS. Using IAS as the model of tonic smooth muscles, Dr. Rattan's basic studies have provided major advances in the field of molecular biology of the tonic versus phasic smooth muscles. The concepts learnt from his studies have direct implications in the molecular mechanisms underlying pathophysiology, and in the targeted therapeutic development in the gastrointestinal motility disorders, and in a number of other organ systems.


Gastrointestinal Motility Disorders; Internal Anal Sphincter; Neurohumoral Control; Immunocytochemistry; Confocal Microscopy; Nonadrenergic Noncholinergic Neurons; Smooth Muscle Tone and Relaxation Molecular Mechanisms; Nitric Oxide; Carbon Monoxide; Heme Oxygenase; RhoA/Rho Kinase; microRNAs; G Protein-Coupled Receptor Signaling; Tissue Cell Culture; Bioengineering; Renin-Angiotensin-System; Prostanoids; Magnetofection; and Aging-Associated Smooth Muscle Changes.


Most Recent Peer-Reviewed Publications

  1. Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2
  2. BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release
  3. Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone
  4. NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy
  5. Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery
  6. In vivo magnetofection: A novel approach for targeted topical delivery of nucleic acids for rectoanal motility disorders
  7. Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone
  8. Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis
  9. Ca2+/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone
  10. Role of muscarinic-3 receptor antibody in systemic sclerosis: Correlation with disease duration and effects of IVIG
  11. Role of microRNAs in gastrointestinal smooth muscle fibrosis and dysfunction: Novel molecular perspectives on the pathophysiology and therapeutic targeting
  12. Association between common variable immunodeficiency and collagenous infiltrative disorders of the gastrointestinal tract: A series of four patients
  13. Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a
  14. Nature of extracellular signal that triggers RhoA/ROCK activation for the basal internal anal sphincter tone in humans
  15. Role of SM22 in the differential regulation of phasic vs. Tonic smooth muscle
  16. Bimodal effect of oxidative stress in internal anal sphincter smooth muscle
  17. Survey of anal sphincter dysfunction using anal manometry in patients with fecal incontinence: a possible guide to therapy
  18. Heme oxygenase-1 upregulation modulates tone and fibroelastic properties of internal anal sphincter
  19. Aging-associated oxidative stress leads to decrease in IAS tone via RhoA/ROCK downregulation
  20. Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer
  21. Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle
  22. Smooth muscle fascicular reorientation is required for esophageal morphogenesis and dependent on Cdo
  23. Smooth muscle-specific myosin phosphatase target subunit 1 (MYPT1): An important piece of the puzzle
  24. Biosynthetic pathways and the role of the mas receptor in the effects of angiotensin-(1-7) in smooth muscles
  25. Bioengineered human IAS reconstructs with functional and molecular properties similar to intact IAS