Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

McKenzie, Steven E.

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Steven E. McKenzie, MD, PhD

Contact Dr. McKenzie

1020 Locust Street
Suite 394
Philadelphia, PA 19107

215-955-3900
215-923-3836 fax

Research & Clinical Interests

Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes. This work, done in collaboration with Dr. Michael Reilly, led to the first model of heparin-induced thrombocytopenia and thrombosis. New work on effects of elevated cholesterol and athrosclerosis on HITT, and on microparticles and tissue factor, is ongoing.

Publications

Most Recent Peer-Reviewed Publications

  1. FcgRIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus
  2. Apoptosis signal-regulating kinase 1 regulates immune-mediated thrombocytopenia, thrombosis, and systemic shock
  3. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets
  4. Platelets disseminate extracellular vesicles in lymph in rheumatoid arthritis
  5. Cleavage of anti-PF4/heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia
  6. The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition
  7. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration
  8. 5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies
  9. Erratum: TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346, a regulatory site of Syk (The Journal of Biological Chemistry (2016) 291 (22427-22441) DOI: 10.1074/jbc.M116.743732)
  10. Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia
  11. TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice
  12. TULA-2 protein phosphatase suppresses activation of syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346 a regulatory site of syk
  13. Mice expressing low levels of CalDAG-GEFI exhibit markedly impaired platelet activation with minor impact on hemostasis
  14. Identification of novel Syk-independent functional roles of FcγRIIa in platelet outside-in signaling using transgenic mice expressing human FcγRIIa
  15. Syk inhibition in ischemic stroke
  16. Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia
  17. The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)
  18. Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice
  19. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs
  20. Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
  21. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression
  22. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
  23. The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome
  24. Identification of a developmental gene expression signature, including hox genes, for the normal human colonic crypt stem cell niche: Overexpression of the signature parallels stem cell overpopulation during colon tumorigenesis
  25. Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia