Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Research Activity

Our strong clinical research program, especially in the fields of acute kidney injury and hypertension, has been complemented by our growing basic research program in regulation of ion transport. We have obtained extramural funding for a broad range of clinical research projects in the areas of diabetic nephropathy, dialysis, nutrition and renal transplantation. Our NIH funded basic science research is focused on hypertension and regulation of ion transplant by FXYD proteins.

Bonita Falkner, MD, Director of Hypertension

Research interests include the genetic basis of essential hypertension, insulin resistance and obesity.

Representative Publications

Macrophage and adipocyte interaction as a source of inflammation in kidney disease

The USPSTF call to inaction on blood pressure screening in children and adolescents

Blood pressure unknowns of sickle cell disease in children

Maternal and gestational influences on childhood blood pressure

What about Stage 1 Hypertension in Young Adults?

Subclinical Systolic and Diastolic Dysfunction Is Evident in Youth with Elevated Blood Pressure

Primordial prevention of high blood pressure in childhood an opportunity not to be missed

Association of blood pressure level with left ventricular mass in adolescents: SHIP AHOY

Effects of the 2017 clinical practice guidelines on hypertension in children and adolescents: A commentary

Too Much Sugar Is Not Good for the Fetus

Ambulatory blood pressure monitoring tolerability and blood pressure status in adolescents: The SHIP AHOY study

Cardiac output versus total peripheral resistance a wrinkle in time

Diagnosis, evaluation, and management of high blood pressure in children and adolescents

Ambulatory hypertension in a pediatric cohort of sickle cell disease

The Childhood Role in Development of Primary Hypertension

Neurocognitive Function in Children with Primary Hypertension after Initiation of Antihypertensive Therapy

The enigma of blood pressure measurement in children with CKD

Development of blood pressure norms and definition of hypertension in children

Changes in the 2017 Pediatric Hypertension Clinical Guidelines

Insulin resistance and other mechanisms of obesity hypertension

Insulin resistance as a determinant of cardiovascular reactivity

Prediction of ambulatory hypertension based on clinic blood pressure percentile in adolescents the Ship AHOY study

Ship-ahoy (study of high blood pressure in pediatrics: Adult hypertension onset in youth) rationale, design, and methods

Monitoring and management of hypertension with obesity in adolescents

Clinical practice guideline for screening and management of high blood pressure in children and adolescents

Maria P. Martinez Cantarin, MD

Research interests include Adipose tissue inflammation, kidney disease and transplant associated hyperglycemia.  

Representative Publications

Macrophage and adipocyte interaction as a source of inflammation in kidney disease

Outcomes of COVID-19-positive kidney transplant recipients: A single-center experience

Effect of CYP3A Inhibition and Induction on the Pharmacokinetics of Suvorexant: Two Phase I, Open-Label, Fixed-Sequence Trials in Healthy Subjects

Correction to: Effect of CYP3A Inhibition and Induction on the Pharmacokinetics of Suvorexant: Two Phase I, Open-Label, Fixed-Sequence Trials in Healthy Subjects (Clinical Drug Investigation, (2019), 10.1007/s40261-019-00764-x)

Kidney Support and Perioperative Care in Kidney Transplantation

Patient Selection and Pretransplantation Care for Kidney Transplant Recipients

Correlation of acute tubular injury in reperfusion biopsy with renal transplant outcomes

Parathyroid Hormone-Related Peptide-Linked Hypercalcemia in a Melanoma Patient Treated with Ipilimumab: Hormone Source and Clinical and Metabolic Correlates

The adipose tissue production of adiponectin is increased in end-stage renal disease

Reverse warburg effect in a patient with aggressive B-cell lymphoma: Is lactic acidosis a paraneoplastic syndrome?

Relationship of adipokines with insulin sensitivity in African Americans

Relationship of blood pressure and obesity with inflammatory cytokines among African Americans

Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

Acute humoral rejection in a zero mismatch deceased donor renal transplant due to an antibody to an HLA-DP α

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

Pooja Singh, M.D.

Research interests include immunological barriers in renal transplantation, sensitization and renal allograft failure management.

Representative Publications

Contemporary incidence and risk factors of post transplant Erythrocytosis in deceased donor kidney transplantation

Center-level Variation in HLA-incompatible Living Donor Kidney Transplantation Outcomes

Outcomes of COVID-19-positive kidney transplant recipients: A single-center experience

An Unusual Case of Proteinuria in a Kidney Donor

Optimising the use of telemedicine in a kidney transplant programme during the coronavirus disease 2019 pandemic

Immune checkpoint inhibitor therapy-associated graft intolerance syndrome in a failed kidney transplant recipient

Urine Injury Biomarkers Are Not Associated with Kidney Transplant Failure

Initial skin cancer screening for solid organ transplant recipients in the United States: Delphi method development of expert consensus guidelines

The authors reply

Deceased-donor acute kidney injury is not associated with kidney allograft failure

Information overload; a response to “Turn down for what? Patient outcomes associated with declining increased infectious risk kidneys”

Tick-borne illness after transplantation: Case and review

Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study

Kidney Support and Perioperative Care in Kidney Transplantation

Patient Selection and Pretransplantation Care for Kidney Transplant Recipients

Acute Renal Failure in Kidney Transplant Recipients

The Incremental Cost of Incompatible Living Donor Kidney Transplantation: A National Cohort Analysis

Successful treatment of donor-derived hepatitis C viral infection in three transplant recipients from a donor at increased risk for bloodborne pathogens

Rapidly Fatal Hemophagocytic Lymphohistiocytosis Developing Within Six Days Following Deceased-Donor Renal Transplantation: Case Report

Survival benefit with kidney transplants from HLA-incompatible live donors

Sensitization trends after renal allograft failure: The role of DQ eplet mismatches in becoming highly sensitized

Need to consider full societal impact of hepatitis B virus-positive donors

Sensitization, pathologic, and imaging findings comparing symptomatic and quiescent failed renal allografts

Quantifying the risk of incompatible kidney transplantation: A multicenter study

Peritransplant kidney biopsies: Comparison of pathologic interpretations and practice patterns of organ procurement organizations

Recent Peer Reviewed Publications by Division

Macrophage and adipocyte interaction as a source of inflammation in kidney disease

Outcomes With Ultrafiltration Among Hospitalized Patients With Acute Heart Failure (from the National Inpatient Sample)

Association Between Intravenous Fluid Resuscitation and Hospital Mortality in Post Cardiac Arrest Patients: A Retrospective Study

Hyperkalemia and Hypertension Post Organ Transplantation – A Management Challenge

Optimizing the assessment of pathogenic anti-HLA antibodies

Renovascular Hypertension

Acute coronary syndromes in the peri-operative period after kidney transplantation in United States

Medication Non-adherence: a Major Cause of Resistant Hypertension

SGLT2 inhibitors: Diabetic kidney disease and beyond

Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Five insights from the Global Burden of Disease Study 2019

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Blood pressure unknowns of sickle cell disease in children

An Unusual Case of Proteinuria in a Kidney Donor

Cardiovascular outcomes, bleeding risk, and achieved blood pressure in patients on long-term anticoagulation with the thrombin antagonist dabigatran or warfarin: Data from the RE-LY trial

Meta-analysis of outcomes of patients with COVID-19 infection with versus without gastrointestinal symptoms

What about Stage 1 Hypertension in Young Adults?

Coronary Artery Disease Screening of Asymptomatic Kidney Transplant Candidates: A Web-Based Survey of Practice Patterns in the United States

Vancomycin in peritoneal dialysis: Clinical pharmacology considerations in therapy

Physical Function in Kidney Transplantation: Current Knowledge and Future Directions

Nephrology fellows’ and program directors’ perceptions of hospital rounds in the United States

Predictors of 30-day re-admissions in patients with infective endocarditis: A national population based cohort study

Development of a generalized model for kidney depth estimation in the Chinese population: A multi-center study