Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Deshpande, Deepak

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Deepak Deshpande, PhD

Deepak Deshpande, PhD

Contact Dr. Deshpande

1020 Locust Street
Room 543B
Philadelphia, PA 19107

(215) 955-3305
(215) 503-5731 fax

Education

PhD, College of Veterinary Medicine, University of Minnesota, 2004
MS, Veterinary College, University of Agricultural Sciences, Bangalore, India, 1997
DMV, Veterinary College, University of Agricultural Sciences, Bangalore, India, 1994

University Appointment

Associate Professor
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine

Professional Societies

American Thoracic Society

Research & Clinical Interests

My laboratory studies intracellular signaling regulating contraction, relaxation and proliferation of airway smooth muscle with particular emphasis on G protein coupled receptor mediated signaling. Current projects include understanding age-dependent changes in airway smooth muscle function (funded by NIA/NIH) and bitter taste receptor signaling in airway smooth muscle (funded by American Asthma Foundation). Airway smooth muscle is the principle contractile component of airways, and contraction and relaxation of ASM regulate airway diameter. Any alteration in ASM function results in bronchoconstriction and difficulty in breathing. Therefore, ASM acts as a primary therapeutic target in obstructive airway diseases such as asthma and COPD. Delineating novel receptors and signaling mechanisms that regulate ASM function would provide basis for developing newer and better drugs to treat asthma. 

Publications

Most Recent Peer-Reviewed Publications

  1. The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR
  2. Editorial overview: Pulmonary 2020 – advances in the pharmacology of obstructive lung diseases
  3. The role of diacylglycerol kinases in allergic airway disease
  4. Therapeutic potential and challenges of bitter taste receptors on lung cells
  5. Role of CD38/cADPR signaling in obstructive pulmonary diseases
  6. A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation
  7. Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2
  8. Reply to Letter to the Editor: “Bnip3 as a potential target to treat airway smooth muscle remodeling in asthma?”
  9. Bitter Taste Receptors: an Answer to Comprehensive Asthma Control?
  10. Effects of ATP-competitive and function-selective ERK inhibitors on airway smooth muscle cell proliferation
  11. Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms
  12. Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle
  13. Autophagy activation in asthma airways remodeling
  14. Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling
  15. NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy
  16. Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases
  17. Bnip3 regulates airway smooth muscle cell focal adhesion and proliferation
  18. Bitter taste receptors for asthma therapeutics
  19. Cooperativity of E-prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle
  20. Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease
  21. Improvement in Therapeutic Efficacy and Reduction in Cellular Toxicity: Introduction of a Novel Anti-PSMA-Conjugated Hybrid Antiandrogen Nanoparticle
  22. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines
  23. New targets for resolution of airway remodeling in obstructive lung diseases [version 1; referees: 2 approved]
  24. Autophagy and airway fibrosis: Is there a link?
  25. CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms