Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Nayak, Ajay

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Ajay Nayak, PhD

Ajay Nayak, PhD

Contact Dr. Nayak

1020 Locust Street
Jefferson Alumni Hall, Room 541
Philadelphia, PA 19107

(215) 503-0141
(215) 503-5731 fax

PhD, School of Medicine, West Virginia University 2012
MSc, University of Mumbai 2006
BSc, University of Mumbai 2004

University Appointment
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine

Professional Societies
American Thoracic Society
American Academy of Allergy, Asthma and Immunology

Research and Clinical Interests
The major focus of my research is to elucidate the underlying mechanisms contributing to allergic responses to Cannabis sativa (marijuana). Exposure to Cannabis components results in aberrant respiratory function including exacerbation of asthma. Furthermore, direct contact with the plant may also result in urticarial rash and angioedema. With increasing legalization of marijuana for medicinal and recreational use more individuals are likely to demonstrate allergic reactions in the near future. We are specifically interested in identifying the major allergens of marijuana and developing standardized tools for clinical diagnostics.

Additional research interests include GPCR signaling, regulation and function (in vitro, ex vivo and in vivo) in the context of lung disease, as well as the pathobiology and treatment of fibrotic lung disease.  



Most Recent Peer-Reviewed Publications

  1. Species-specific evaluation of 2 patients with suspected crab allergy
  2. Occupational Allergies to Cannabis
  3. Inhalation of stachybotrys chartarum fragments induces pulmonary arterial remodeling
  4. The proton-sensing receptor ovarian cancer G-protein coupled receptor 1 (OGR1) in airway physiology and disease
  5. Therapeutic potential and challenges of bitter taste receptors on lung cells
  6. Cannabis: An emerging occupational allergen?
  7. Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
  8. Bitter Taste Receptors: an Answer to Comprehensive Asthma Control?
  9. Endotoxin exposures during harvesting and processing cannabis at an outdoor cannabis farm
  10. Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling
  11. Glucocorticoids and airway smooth muscle: A few more answers, still more questions
  12. Bitter taste receptors for asthma therapeutics
  13. Cooperativity of E-prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle
  14. Aspergillus fumigatus viability drives allergic responses to inhaled conidia
  15. Microbial hazards during harvesting and processing at an outdoor United States cannabis farm
  16. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines
  17. New targets for resolution of airway remodeling in obstructive lung diseases [version 1; referees: 2 approved]
  18. Allergenicity to Cannabis sativa L.: And methods to assess personal exposure
  19. Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice
  20. Potential inhibitory influence of miRNA 210 on regulatory T cells during epicutaneous chemical sensitization
  21. Topical application of the anti-microbial chemical triclosan induces immunomodulatory responses through the S100A8/A9-TLR4 pathway
  22. Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure
  23. Subchronic exposures to fungal bioaerosols promotes allergic pulmonary inflammation in naïve mice
  24. Characterization and comparative analysis of 2,4-toluene diisocyanate and 1,6-hexamethylene diisocyanate haptenated human serum albumin and hemoglobin
  25. Triclosan induces thymic stromal lymphopoietin in skin promoting Th2 allergic responses