Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Wang, Bin

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Bin Wang, PhD

Bin Wang, PhD

Contact Dr. Wang

1020 Locust Street
Jefferson Alumni Hall, Room 543
Philadelphia, PA 19107

(215) 503-8226
(215) 503-5731 fax

Medical School

PhD Pharmacology, Anhui Medical University, Hefei, China - 1999
MS Pharmacology, Anhui Medical University, Hefei, - 1993

University Appointment

Assistant Professor
Department of Medicine, Division of Endocrinology, Diabetes & Metabolic Diseases

Professional Societies

American Society for Bone and Mineral Research
The Endocrine Society
American College of Rheumatology

Research & Clinical Interests

Dr. Wang's laboratory is investigating the roles of parathyroid hormone (PTH)/PTH related protein (PTHrP)–activated PTH receptor in musculoskeletal diseases. Current projects include:

(1) Characterization of bimodal effects of PTH on bone metabolism. The long-term objective is to identify new compounds that can enhance the anabolic effect of PTH or PTHrP for the treatment of osteoporosis.

(2) Determining whether and how PTHrP plays a pathogenic role in articular cartilage degeneration (osteoarthritis) during aging.

(3) Characterization of the interaction of PTH receptor with other GPCRs. The purpose of this research will illustrate how PTH receptor coordinates with other GPCRs to maintain musculoskeletal homeostasis.

The overall mission of my research is to advance knowledge in the fields of GPCR biological and musculoskeletal disease research and translate the scientific discoveries into improved health.


Most Recent Peer-Reviewed Publications

  1. Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle
  2. Effect of the PTHrP(1-34) analog abaloparatide on inducing chondrogenesis involves inhibition of intracellular reactive oxygen species production
  3. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines
  4. PTH1R-CaSR Cross Talk: New Treatment Options for Breast Cancer Osteolytic Bone Metastases
  5. Ixazomib enhances parathyroid hormone-induced ?-catenin/T-cell factor signaling by dissociating ?-catenin from the parathyroid hormone receptor
  6. Disruption of ß-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation
  7. The proteasome inhibitor carfilzomib suppresses parathyroid hormone-induced osteoclastogenesis through a RANKL-mediated signaling pathway
  8. Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2)
  9. Astragaloside IV possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage
  10. NHERF1 regulation of PTH-dependent bimodal Pi transport in osteoblasts
  11. Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport
  12. Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting
  13. Dynamic Na +-H + exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains
  14. A naturally occurring isoform inhibits parathyroid hormone receptor trafficking and signaling
  15. Formation of a ternary complex among NHERF1, β-arrestin, and parathyroid hormone receptor
  16. Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of Gα protein subunits
  17. Generation of human PTH1R construct with flag epitope located internally: Comparison of two-fragment assembly by using PCR overlap extension or ligase
  18. NHERF1 regulates parathyroid hormone receptor desensitization: Interference with β-arrestin binding
  19. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis
  20. Na/H exchange regulatory factor 1, a novel AKT-associating protein, regulates extracellular signal-regulated kinase signaling through a B-Raf-mediated pathway
  21. NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling
  22. NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors
  23. Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
  24. Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription
  25. Anti-aging effect of astragalosides and its mechanism of action