Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Penn, Raymond B.

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Raymond B. Penn

Raymond B. Penn, PhD

Contact Dr. Penn

1020 Locust Street
Suite 543C
Philadelphia, PA 19107

(215) 955-9982
(215) 503-5731 fax

Education

PhD Physiology, Temple University College of Medicine 1988
MS Ed Education, University of Pennsylvania 1980
BA History, University of Pennsylvania 1980

University Appointment

Professor of Medicine
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Director, Center for Translational Medicine
Director of Pulmonary Research, Jefferson - Jane and Leonard Korman Lung Center

Professional Societies

American Thoracic Society
American Chemical Society
British Pharmacological Society

Research & Clinical Interests

Airway biology; GPCR biology; Asthma pharmacology; Renal transporter biology; Cancer biology; Asthma, COPD, obstructive and fibrotic lung diseases; Chronic metabolic acidosis

The major focus of my research is to identify cellular and molecular mechanisms by which G protein-coupled receptors (GPCRs) mediate important functions in airway cells. GPCR signaling regulates contractile function, synthesis and release of autocrine factors, and cell growth/survival in various airway cells, including airway smooth muscle (ASM), airway epithelium, lung fibroblasts, and T lymphocytes. Aberrant GPCR signaling or exaggerated presentation of GPCR stimuli can promote ASM hypercontractility, airway remodeling, and ASM hyperplasia/hypertrophy, all of which contribute to the pathogenesis of asthma and COPD. Moreover, GPCRs appear to mediate important mitogenic and survival signaling pathways in cells comprising the tumor microenvironment- including epithelia, fibroblasts, stem cells, and inflammatory cells- rendering them potentially important therapeutic targets in the treatment of cancer. Finally, many GPCR genes possess mutations that alter their expression or function; we are particularly interested in characterizing such altered function and its contribution to disease state or disease therapy.

Publications

Most Recent Peer-Reviewed Publications

  1. Mast cells in asthma: Here I am, stuck in the middle with you
  2. Agonist-specific desensitization of PGE2-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts
  3. The proton-sensing receptor ovarian cancer G-protein coupled receptor 1 (OGR1) in airway physiology and disease
  4. A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation
  5. Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2
  6. Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
  7. Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle
  8. Give me a fork: Can autophagy research solve the riddle of airway remodeling in asthma?
  9. Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling
  10. NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy
  11. Methods to Investigate β-Arrestin-Mediated Regulation of GPCR Function in Human Airway Smooth Muscle
  12. Cooperativity of E-prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle
  13. Pepducins as a potential treatment strategy for asthma and COPD
  14. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines
  15. New targets for resolution of airway remodeling in obstructive lung diseases [version 1; referees: 2 approved]
  16. Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone
  17. 12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner
  18. An official American thoracic society research statement: Current challenges facing research and therapeutic advances in airway remodeling
  19. Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones
  20. Phosphodiesterase 4 inhibitors attenuate the asthma phenotype produced by β2-adrenoceptor agonists in phenylethanolamine N-methyltransferase-knockout mice