Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Summer, Ross

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Ross Summer

Ross Summer, MD

Contact Dr. Summer

1025 Walnut Street
Suite 412
Philadelphia, PA 19107

(215) 503-3893
(215) 955-0830 fax

Medical School

Louisiana State University, New Orleans, LA


Johns Hopkins University


Boston University School of Medicine

Board Certification

Internal Medicine
Pulmonary Medicine
Critical Care Medicine

University Appointment

Professor of Medicine
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine

Clinical Interests

Acute lung injury
Interstitial lung disease
General Pulmonary Medicine

Research & Clinical Interests

Dr. Summer is a board certified pulmonary and critical care physician and an NIH-funded basic science investigator. Work in his laboratory aims to understand the molecular and cellular mechanisms underlying cell and whole organ dysfunction in response to pulmonary insult. His work emphasizes the functional interconnections between cell signaling, metabolism and injury/repair mechanisms, and his laboratory applies a broad range of experimental approaches to characterize changes in the lung after acute (e.g., LPS, bleomycin, radiation) or chronic (e.g., obesity, chronic alcohol ingestion) pulmonary insult.  Dr. Summer’s clinical interests encompass a broad range of respiratory disorders but his outpatient clinical focus is in care and in the treatment of patients with fibrotic lung disease.


Most Recent Peer-Reviewed Publications

  1. Acute Exacerbation of Interstitial Lung Disease as a Sequela of COVID-19 Pneumonia
  2. On Race and the Environment in the COVID-19 Pandemic
  3. COVID-19 Retesting in the Primary Care Setting
  4. A Comprehensive Review of Manifestations of Novel Coronaviruses in the Context of Deadly COVID-19 Global Pandemic
  5. E-cigarettes and Vaping Associated Lung Injury: A Case Series and Brief Review
  6. Alcohol-induced lipid dysregulation impairs glycolytic responses to LPS in alveolar macrophages
  7. Maxed out on glycolysis: Alveolar macrophages rely on oxidative phosphorylation for cytokine production
  8. Pulmonary circulation in obesity, diabetes, and metabolic syndrome
  9. Tocilizumab in the Management of COVID-19: A Preliminary Report
  10. The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase
  11. Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust
  12. The involvement of GM-CSF deficiencies in parallel pathways of pulmonary alveolar proteinosis and the alcoholic lung
  13. Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome
  14. Time to personalize the treatment of anti-MDA-5 associated lung disease
  15. Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
  16. Metabolic Reprogramming as a Driver of Fibroblast Activation in PulmonaryFibrosis
  17. Proteomic profile of TGF-β1 treated lung fibroblasts identifies novel markers of activated fibroblasts in the silica exposed rat lung
  18. Cellular Metabolism in Lung Health and Disease
  19. Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis
  20. Lipid metabolism: A new player in the conundrum of lung fibrosis
  21. Activated fibroblasts: Gluttonous for glutamine
  22. Combination of biochanin a and temozolomide impairs tumor growth by modulating cell metabolism in glioblastoma multiforme
  23. Nur77 limits endothelial barrier disruption to LPS in the mouse lung
  24. Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice
  25. Lipid synthesis is required to resolve endoplasmic reticulum stress and limit fibrotic responses in the lung