Philadelphia University + Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Summer, Ross

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Ross Summer

Ross Summer, MD

Contact Dr. Summer

1025 Walnut Street
Suite 412
Philadelphia, PA 19107

(215) 503-3893
(215) 955-0830 fax

Medical School

Louisiana State University, New Orleans, LA

Residency

Johns Hopkins University

Fellowship

Boston University School of Medicine

Board Certification

Internal Medicine
Pulmonary Medicine
Critical Care Medicine

University Appointment

Professor of Medicine
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine

Clinical Interests

Acute lung injury
Interstitial lung disease
Dyspnea
General Pulmonary Medicine

Research & Clinical Interests

Dr. Summer is a board certified pulmonary and critical care physician and an NIH-funded basic science investigator. Work in his laboratory aims to understand the molecular and cellular mechanisms underlying cell and whole organ dysfunction in response to pulmonary insult. His work emphasizes the functional interconnections between cell signaling, metabolism and injury/repair mechanisms, and his laboratory applies a broad range of experimental approaches to characterize changes in the lung after acute (e.g., LPS, bleomycin, radiation) or chronic (e.g., obesity, chronic alcohol ingestion) pulmonary insult.  Dr. Summer’s clinical interests encompass a broad range of respiratory disorders but his outpatient clinical focus is in care and in the treatment of patients with fibrotic lung disease.

Publications

Most Recent Peer-Reviewed Publications

  1. Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust
  2. Proteomic profile of TGF-β1 treated lung fibroblasts identifies novel markers of activated fibroblasts in the silica exposed rat lung
  3. Cellular Metabolism in Lung Health and Disease
  4. Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis
  5. Combination of biochanin a and temozolomide impairs tumor growth by modulating cell metabolism in glioblastoma multiforme
  6. Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice
  7. Lipid synthesis is required to resolve endoplasmic reticulum stress and limit fibrotic responses in the lung
  8. Silicosis decreases bone mineral density in rats
  9. Time to personalize the treatment of anti-MDA-5 associated lung disease
  10. Severe airflow obstruction in a man with stomatitis and lymphadenopathy
  11. Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis
  12. Protein folding and the challenges of maintaining endoplasmic reticulum proteostasis in idiopathic pulmonary fibrosis
  13. Target-Specific Delivery of an Antibody That Blocks the Formation of Collagen Deposits in Skin and Lung
  14. Obesity-induced endoplasmic reticulum stress causes lung endothelial dysfunction and promotes acute lung injury
  15. An official American thoracic society workshop report: Obesity and metabolism an emerging frontier in lung health and disease
  16. Binding of CIB1 to the aIIb tail of aIIbβ3 is required for FAK recruitment and activation in platelets
  17. T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity
  18. Chronic Obstructive Pulmonary Disease
  19. Surfactant lipids at the host-environment interface metabolic sensors, suppressors, and effectors of inflammatory lung disease
  20. Pulmonary alveolar proteinosis: Pathogenesis, diagnosis, and management