Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Summer, Ross

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Ross Summer

Ross Summer, MD

Contact Dr. Summer

1025 Walnut Street
Suite 412
Philadelphia, PA 19107

(215) 503-3893
(215) 955-0830 fax

Medical School

Louisiana State University, New Orleans, LA


Johns Hopkins University


Boston University School of Medicine

Board Certification

Internal Medicine
Pulmonary Medicine
Critical Care Medicine

University Appointment

Professor of Medicine
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine

Clinical Interests

Acute lung injury
Interstitial lung disease
General Pulmonary Medicine

Research & Clinical Interests

Dr. Summer is a board certified pulmonary and critical care physician and an NIH-funded basic science investigator. Work in his laboratory aims to understand the molecular and cellular mechanisms underlying cell and whole organ dysfunction in response to pulmonary insult. His work emphasizes the functional interconnections between cell signaling, metabolism and injury/repair mechanisms, and his laboratory applies a broad range of experimental approaches to characterize changes in the lung after acute (e.g., LPS, bleomycin, radiation) or chronic (e.g., obesity, chronic alcohol ingestion) pulmonary insult.  Dr. Summer’s clinical interests encompass a broad range of respiratory disorders but his outpatient clinical focus is in care and in the treatment of patients with fibrotic lung disease.


Most Recent Peer-Reviewed Publications

  1. Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung
  2. Tocilizumab in the Management of COVID-19: A Preliminary Report
  3. Acute Exacerbation of Interstitial Lung Disease as a Sequela of COVID-19 Pneumonia
  4. On Race and the Environment in the COVID-19 Pandemic
  5. COVID-19 Retesting in the Primary Care Setting
  6. Retraction: Obesity-induced endoplasmic reticulum stress causes lung endothelial dysfunction and promotes acute lung injury
  7. A Comprehensive Review of Manifestations of Novel Coronaviruses in the Context of Deadly COVID-19 Global Pandemic
  8. E-cigarettes and Vaping Associated Lung Injury: A Case Series and Brief Review
  9. Alcohol-induced lipid dysregulation impairs glycolytic responses to LPS in alveolar macrophages
  10. Maxed out on glycolysis: Alveolar macrophages rely on oxidative phosphorylation for cytokine production
  11. Pulmonary circulation in obesity, diabetes, and metabolic syndrome
  12. The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase
  13. Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust
  14. The involvement of GM-CSF deficiencies in parallel pathways of pulmonary alveolar proteinosis and the alcoholic lung
  15. Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome
  16. Time to personalize the treatment of anti-MDA-5 associated lung disease
  17. Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
  18. Metabolic Reprogramming as a Driver of Fibroblast Activation in PulmonaryFibrosis
  19. Proteomic profile of TGF-β1 treated lung fibroblasts identifies novel markers of activated fibroblasts in the silica exposed rat lung
  20. Cellular Metabolism in Lung Health and Disease
  21. Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis
  22. Lipid metabolism: A new player in the conundrum of lung fibrosis
  23. Activated fibroblasts: Gluttonous for glutamine
  24. Combination of biochanin a and temozolomide impairs tumor growth by modulating cell metabolism in glioblastoma multiforme
  25. Nur77 limits endothelial barrier disruption to LPS in the mouse lung