Philadelphia University + Thomas Jefferson University

MD/PhD Program
Students


Meet Our Current Students

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Maria Gubbiotti
mag010@jefferson.edu

 

 

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Undergrad   The University of Scranton, BS, 2011
Year   MD/PhD 8, SKMC-4
Mentor   Renato V. Iozzo, MD, PhD
PhD Program

Research Interests
  Cell Biology & Regenerative Medicine

I am interested in studying the nuances of the tumor microenvironment with an emphasis on extracellular matrix outside-in signaling. Though my thesis work focused heavily on proteoglycan regulation of autophagy and angiogenesis, I am also interested in tumor immunology and how the inflammatory response can equally affect neovascularization, tumor growth, and metastasis.
Hobbies/Interests   Having grown up in a rural region of Pennsylvania, I have been an avid equestrian for the majority of my life. I enjoy training young and problem horses with an emphasis on re-training racehorses for second careers. I have also dabbled in long-distance running, completing the 2015 Steamtown and 2016 Philadelphia Marathons.
Favorite Places/Things
to Do in Philadelphia
  Kawaii Kitty Café to get my cat fix, Bleu Sushi for the great food and atmosphere, Hawthorne Community Garden for a respite from the bustle of the city, Tango karaoke for a fun night out
Honors/Awards  

McClellan Surgical Honor Society, 2018
Best Poster, Gordon Research Conference for Proteoglycans, 2016
Thomas Jefferson University College of Biomedical Sciences Alumni Travel Fellowship, 2016 (2)
Stephanie Schulz Memorial Award, Best Poster Sigma Xi Research Day, 2016
AOA Research Symposium, Third Place Podium Talk, 2016
Hobart Armory Hare Honor Society, 2013
Pathology Program for Advanced Study (formerly Pathology Honors Program), 2012
Excellence in Biochemistry, Cell and Molecular Biology (undergraduate), 2011
University of Scranton President’s Research Fellowship (undergraduate), 2010 and 2008
Barry M. Goldwater Scholarship (undergraduate), 2010

Publications  

Iozzo, RV, Gubbiotti, MA. (2018). Extracellular matrix: The driving force of mammalian diseases. Matrix Biol. In press.

Torres, A., Gubbiotti, MA., Iozzo, RV. (2017). Decorin-inducible Peg3 evokes Beclin 1-mediated autophagy and Thrombospondin 1-mediated angiostasis. J. Biol. Chem. 292:5055-69.

Schaefer, L., Tredup, C., Gubbiotti, MA., Iozzo, RV. (2016). Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J. 284:10-26.

Gubbiotti, MA., Vallet, SD., Ricard-Blum, S., Iozzo, RV. (2016). Decorin interacting network: a comprehensive analysis of decorin-binding partners and their versatile functions. Matrix Biol. 55:7-21.

Gubbiotti, MA., Neill, T, Iozzo, RV. (2016). A current view of perlecan in physiology and pathology: A mosaic of functions. Matrix Biol. 9:45-53.

*Goyal, A., *Gubbiotti, MA., Chery, DR., Han, L., Iozzo, RV. (2016). Endorepellin-evoked autophagy contributes to angiostasis. J. Biol. Chem. 291:19245-56.


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Lauren Rosenblum
lauren.rosenblum@jefferson.edu

 

 

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Undergrad   Yale University, BS, 2009
Year   MD/PhD 8, SKMC-4
Mentor   Davide Trotti, PhD
PhD Program

Research Interests
  Neuroscience

Currently evolving… I came into med school interested in medical imaging, did my PhD studying the molecular pathogenesis of ALS, and I’m now exploring research in surgery.
Hobbies/Interests   Traveling, hiking, karate, ice cream
Favorite Places/Things
to Do in Philadelphia
  Reading Terminal Market, Scoop DeVille, Race Street Pier
Honors/Awards    
Publications  

Rosenblum, L.*, Gaur S.*, Harmon S.*, Shih J. H., Greer M. D., Mehralivand S., Merino M. J, Wood B. J., Pinto P. A., Choyke P. L., Turkbey B. (In publication). Can ADC Values Assist PI-RADSv2 DWI Scoring? A Correlation Study Using the PI-RADSv2 and ISUP Systems. American Journal of Roentgenology. (*Co-first authors)

Rosenblum, L. T., Shamamandri-Markandaiah, S., Ghosh, B., Foran, E., Lepore, A. C., Pasinelli, P., & Trotti, D. (2017). Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Experimental Neurology, 292, 145–153.

Rosenblum, L. T., & Trotti, D. (2017). EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis. In Glial Amino Acid Transporters (pp. 117–136). Springer, Cham.

Foran, E., Rosenblum, L., Bogush, A., Pasinelli, P., & Trotti, D. (2014). Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia, 62(8), 1241-53.

Foran, E., Rosenblum, L., Bogush, A. I., & Trotti, D. (2013). Sumoylation of Critical Proteins in Amyotrophic Lateral Sclerosis: Emerging Pathways of Pathogenesis. NeuroMolecular Medicine, 15(4), 760–770.

Pre-Jefferson publications:

Jagoda, E. M., Lang, L., Bhadrasetty, V., Histed, S., Williams, M., Kramer-Marek, G., Mena, E., Rosenblum, L., Marik, J., Tinianow, J.N., Choyke, P. (2012). Immuno-PET of the Hepatocyte Growth Factor Receptor Met Using the 1-Armed Antibody Onartuzumab. Journal of Nuclear Medicine, 53(10), 1592–1600.


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Jason You
jason.you@jefferson.edu

 

 

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Undergrad   University of Pennsylvania, BS, 2008
Year   MD/PhD 8, SKMC-4
Mentor   Jeannie Chin, PhD
PhD Program

Research Interests
  Neuroscience

Epigenetic regulation of hippocampal function and cognition in Alzheimer’s disease and epilepsy
Hobbies/Interests   Music – I play keyboard/synth in a local band specializing in original music
Games – collector of video/board games, amateur poker player
History and archeology – particularly things related to ancient Egypt
Comic books/movies – Marvel > DC (sorry Justice League)
Everything on Netflix and HBO
Favorite Places/Things
to Do in Philadelphia
  Trivia night, Board game night, Pop-up beer gardens, Run
Honors/Awards   2011     Physiology Distinction Letter
2011     Hep B Free Philly Certificate of Appreciation
2012     Hobart Amory Hare (HAH) Medical Honors Society
2012     Program for Advanced Study in Pathology
2012     Association of Pathology Chairs (APC) National Pathology Honor Society
2013     Sigma Xi Grant in Aid of Research
2014     Sigma Xi Research Day Award
2014     JGSBS Alumni Association Graduate Student Travel Fellowship
2015     Ruth L. Kirschstein National Research Service Award
2015     Baylor College of Medicine Award
2018     Alpha Omega Alpha (AOA) Medical Honors Society
 Publications  

You JC, Stephens GS, Fu CH, Zhang X, Liu Y, Chin J (2018). “Genome-wide profiling reveals functional diversification of ∆FosB gene targets in the hippocampus of an Alzheimer’s disease mouse model.” PLoS ONE 13(2): e0192508.

You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J (2017). “Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits.” Nature Medicine 23(11):1377-1383. PMID: 29035369

Corbett BF, You JC, Zhang X, Pyfer MS, Tosi U, Iascone DM, Petrof I, Hazra A, Fu CH, Stephens GS, Ashok AA, Aschmies S, Zhao L, Nestler EJ, Chin J (2017). “ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease.” Cell Reports 20(2):344-355. PMID: 28700937

Stephens GS, You JC, Fu CH, Chin J (2017). “Molecular Mechanisms of Synaptic Plasticity and Memory and Their Dysfunction in Alzheimer’s Disease. Learning and Memory: A Comprehensive Reference, 2nd Edition (pp. 65-135). Oxford, UK: Elsevier. https://doi.org/10.1016/B978-0-12-809324-5.21126-7

Hazra A, Corbett BF, You JC, Aschmies S, Zhao L, Li K, Lepore AC, Marsh ED, Chin J (2016). “Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer’s disease.” Neurobiology of Aging 44:96-107. PMID: 27318137

(Undergraduate)

You JC, Yang H, Lai Y, Simon L, Au J, Burkart AL (2015). “ARID2, p110α, p53 and β-catenin protein expression in hepatocellular carcinoma and important clinicopathologic implications.” Human Pathology 46(7):1068-77. PMID: 25701229

Tripepi M, You JC, Temel S, Onder O, Brisson D, Pohlschroder M (2012). “N-glycosylation of Haloferax volcanii flagellins requires known Agl proteins and is essential for biosynthesis of stable flagella.” Journal of Bacteriology 194(18):4876-4887. PMID: 22730124.


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Hyowon Choi
hyowon.choi@jefferson.edu

 

 

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Undergrad   Mount Holyoke College, BA, 2009
Year   MD/PhD 7, SKMC-3
Mentor   Makarand V. Risbud, PhD
PhD Program

Research Interests
  Cell Biology & Regenerative Medicine

My thesis project involves understanding the regulatory mechanism of autophagy in nucleus pulposus of intervertebral disc, and determining the role of primary cilia in osmo-regulation and maintenance of nucleus pulposus. The knowledge gained from my research will enhance our understanding of nucleus pulposus biology, and ultimately contribute to improving treatments for low back pain.
Hobbies/Interests   I like painting/drawing, and trying out new food spots.
Favorite Places/Things
to Do in Philadelphia
  Biking along the Schuylkill River, going to art museums, and visiting Longwood Gardens
Honors/Awards   4th International Spine Research Symposium Poster Award (2017)
Orthopaedic Research Society Annual Meeting Spine Section Poster Award (2017)
International Philadelphia Spine Research Symposium Podium Award in Cell Biology, Disease and Pain Mechanisms (2015)
 
 Publications  

Choi, H., Chaiyamongkol, W., Doolittle, A.C., Johnson, Z.I., Gogate, S.S., Schoepflin, Z.R., Shapiro, I.M., Risbud, M.V. 2018. COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells. J Biol Chem. [Epub ahead of print] PMID: 29700115.

Choi, H., Tessier, S., Silagi, E.S., Kyada, R., Yousefi, F., Pleshko, N., Shapiro, I.M., Risbud, M.V. 2018. A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. Matrix Biol. [Epub ahead of print] PMID: 29605718.

Liu, C., Choi, H., Johnson, Z.I., Tian, J., Shapiro, I.M., Risbud, M.V. 2017. Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. Sci Rep. 7(1):4543. PMID: 28674405.

 

Choi, H., Merceron, C., Mangiavini, L., Seifert, E.L., Schipani, E., Shapiro, I.M., and Risbud, M.V. 2016. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIFA signaling. Autophagy. 12(9):1631-46. PMID: 27314664.

Hwang, P.Y., Jing, L., Chen, J., Lim, F.L., Tang, R., Choi, H., Cheung, K.M., Risbud, M.V., Gersbach, C.A., Guilak, F., Leung, V.Y., and Setton, L.A. 2016. N-cadherin is Key to Expression of the nucleus pulposus cell phenotype under selective substrate culture conditions. Sci Rep. 6:28038. PMID: 27292569.

Suyama, K., Silagi, E.S., Choi, H., Sakabe, K., Mochida, J., Shapiro, I.M., and Risbud, M.V. 2016. Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Oncotarget 7(17):23056-71. PMID: 27049729.

Schoepflin, Z.R., Choi, H., Johnson, Z.I., Shapiro, I.M., and Risbud, M.V. 2016. Molecular basis of disc degeneration/regeneration. In: Vaccaro A, Koerner J, Kim D, editors. Recent Advances in Spinal Surgery. 1st ed. Philadelphia (PA): Jaypee Brothers Medical Publishers. 55-68.

Johnson, Z.I., Schoepflin, Z.R., Choi, H., and Risbud, M.V. 2015. Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration. Eur Cell Mater. 30:104-16; discussion 116-7. PMID: 26388614.

Choi, H., Johnson, Z.I., and Risbud, M.V. 2015. Understanding nucleus pulposus cell phenotype: A prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Curr Stem Cell Res Ther. 10(4):307-16. PMID: 25584906.


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Dante Merlino
dante.merlino@jefferson.edu

 

 

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Undergrad   Wake Forest University, BS, 2011
Year   MD/PhD 7, SKMC-3
Mentor   Scott Waldman, MD, PhD
PhD Program

Research Interests
  Neuroscience

My research interests involve studying gut-brain neuroendocrine axes to better understand how the brain interprets intestinal signals conveying feeding status to influence appetite and subsequent motivation and feeding behavior. More specifically, my research has investigated how the intestinal hormone uroguanylin communicates via its receptor, guanylate cyclase C, in the hypothalamus and ventral midbrain to mediate homeostatic and hedonic feeding.
Hobbies/Interests   I enjoy playing poker, running, playing tennis (that includes table tennis!) and spending time with my wife, Greta, and our dog, Jacob. I also love all Philadelphia sports, but there’s a special place in my heart for the Super Bowl champion Philadelphia Eagles.
Favorite Places/Things
to Do in Philadelphia
  I love going to Eagles games at Lincoln Financial Field, grilling in my tiny Philadelphia backyard, and running along Boathouse Row on Kelly Drive.
Honors/Awards  

Preclinical Honors and Awards: Foundations of Clinical Medicine, Introduction to Clinical Medicine II, Physical Diagnosis, Spring 2013; Immunology and Infectious Disease, Pathology and Pharmacology, Fall 2012; Neuroscience, The Systems (Histology and Physiology), Introduction to Clinical Medicine I, Spring 2012; Molecular and Cellular Basis of Medicine, Human Form and Development,           Fall 2011

Brubaker Physiology Award

Pre Doctoral Grant Awards:
PhRMA Foundation (Pre Doctoral Fellowship in Pre Pharmacology/Toxicology). Investigation of the Neuroprotective Effects of Guanylyl Cyclase C.

NIH (1F30DK103492-01A1). Obesity Suppresses the GUCY2C endocrine Gut-Brain Axis Disrupting Satiety

 Publications  

Merlino, D.J., Charsar, B.A., Rappaport, J.A. Lepore, A.C., Snook, A.E., Waldman, S.A.  GUCY2C in distinct circuits in hypothalamus and midbrain. Submitted.

Lin A., Xiang B., Merlino D.J., Baybutt T.R., Sahu J., Fridman A., Snook A.E., Miller V. Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors. Oncoimmunology. 2018; In Press.

Kim, G. W., Lin, J. E., Snook, A. E., Aing, A. S., Merlino, D. J., Li, P., & Waldman, S. A. (2016). Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity. Nutrition & Diabetes, 6(5), e211.

Blomain, E. S., Merlino, D. J., Pattison, A. M., Snook, A. E., & Waldman, S. A. (2016). GUCY2C hormone axis at the intersection of obesity and colorectal cancer. Molecular Pharmacology, mol-115.

Pattison, A. M., Blomain, E. S., Merlino, D. J., Wang, F., Crissey, M. A. S., Kraft, C. L., ... & Waldman, S. A. (2016). Intestinal enteroids model guanylate cyclase C-dependent secretion induced by heat-stable enterotoxins. Infection and Immunity, 84(10), 3083-3091.

Snook, A.E., Blomain, E.S., Aing, A.S., Merlino, D.J., and Waldman, S.A. (2016). Guanylyl Cyclase Receptors, In Encyclopedia of Cell Biology, edited by Ralph A. Bradshaw and Philip D. Stahl, Academic Press, Waltham, 2016, Pages 56-60, ISBN 9780123947963, http://dx.doi.org/10.1016/B978-0-12-394447-4.30005-0.

Merlino, D.J., Blomain, E.S., Aing, A.S., and Waldman, S.A. (2014). Gut-brain endocrine axes in weight regulation and obesity pharmacotherapy. Journal of Clinical Medicine, 3(3), 763-794.

Marszalowicz, G. P., Snook, A. E., Magee, M. S., Merlino, D.J., Berman-Booty, L. D., and Waldman, S. A. (2014). GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer. Oncotarget, 5(19), 9460-9471.


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Tanziyah Muqeem
tanziyah.muqeem@jefferson.edu

 

 

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Undergrad   Johns Hopkins University, BS, 2012
Year   MD/PhD 7, SKMC-3
Mentor   Manuel Covarrubias, MD, PhD
PhD Program

Research Interests
  Neuroscience

My research interests generally include gaining a deeper understanding of neuronal wiring in the nervous system. This covers topics such as sensory (visual, auditory, somatosensory, etc) processing and integration, brain circuit dysfunction in disease, and neurodevelopmental disorders. Ultimately, I am interested in using a combination of mathematics and biology to understand physiological processes that make us who we are and pathophysiological processes that cause dysfunction in disease.
Hobbies/Interests   I love writing poetry, short stories, and really any kind of creative writing. I enjoy taking amateur photographs. I like reading science fiction and fantasy books as well as books on the history of civilizations. I love to cook, and I love going to Farmer’s Markets.
Favorite Places/Things
to Do in Philadelphia
  The Philadelphia restaurant scene is fantastic. Spruce Street Harbor Park is one of my favorite places to go in the summer. I like going to the Franklin Institute whenever there is an interesting exhibit. The Free Library of Philadelphia has an unbelievably extensive collection of paper books, audiobooks, ebooks, TV shows, and films. I love going to plays at any of the many wonderful theaters in the area (my particular favorites are the Lantern Theater and the InterAct Theater).
Honors/Awards   Taconic Biosciences Society for Neuroscience Travel Award
Frederic Rieders Family Renaissance Foundation Graduate Student Award
Sigma Xi Poster Award
Sigma Xi Grant-in-Aid of Research Award
Applied Mathematics and Statistics Achievement Award (Undergrad)
Tau Beta Pi Engineering Honor Society (inducted in Undergrad)
Most Innovative Undergraduate Design (Undergrad)
 Publications  

Zemel BM, Ritter DM, Covarrubias M, Muqeem T. A-type Kv channels in dorsal root ganglion neurons: diversity, function, and dysfunction. In revision

Muqeem T, Ghosh B, Pinto V, Lepore AC, Covarrubias M. Regulation of nociceptive glutamatergic signaling by presynaptic Kv3.4 channels in the rat spinal dorsal horn. J Neurosci 38(15): 3729-3740, 2018.

Zemel BM, Muqeem T, Brown EV, Goulao M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin dysregulation underlies spinal cord injury-induced K+ channel dysfunction in DRG neurons. J Neurosci 37(34): 8256-8272, 2017.

Laflin KE, Morris CJ, Muqeem T, Gracias DH. Laser triggered sequential folding of microstructures. Applied Physics Letters 101(13), 2012. (Undergrad)


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Elaine Yang
elaine.yang@jefferson.edu

 

 

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Undergrad   Johns Hopkins University, BS, 2010
Year   MD/PhD 7, SKMC-3
Mentor   Manuel Covarrubias, MD, PhD
PhD Program

Research Interests
  Biochemistry & Molecular Pharmacology

My current research interests include voltage-gated ion channels, specifically the study of their structure, function, and pharmacology. I also have a background in engineering and medical devices, which I hope to incorporate into my future career in some capacity.
Hobbies/Interests   I like to bake all sorts of desserts (pie, cupcakes, tarts… my friends and lab-mates like it too!). I am also really into all types of fitness, in particular dance, swimming, spin, and yoga/Pilates.
Favorite Places/Things
to Do in Philadelphia
  Most of my interests revolve around food. Luckily, for me, Philadelphia is one of the best places to try new and unique restaurants, but my favorite place in Philadelphia has to be Federal Donuts. The hot and fresh donuts? Enough said. My home-away-from-home is the gym, and I absolutely love Philly Dance Fitness, where I dance away stress… and all of those donuts.
Honors/Awards   Jefferson College of Biomedical Sciences Alumni Association Travel Fellowship (2015, 2016)
Association for Women in Science Philadelphia, Robert E. Davies Travel Award (2016)
Ruth L. Kirschstein National Research Service Award, F30 Fellowship (2017)
Thomas Jefferson University Sigma Xi Research Day Poster Competition Award (2017)
 Publications  

Yang E, Zhi L, Liang Q, and Covarrubias M. “Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics”. Methods in Enzymology. 2018; 602:339-368. DOI: 10.1016/bs.mie.2018.01.013.

Yang E, Granata D, Eckenhoff R, Carnevale V, and Covarrubias M. “Propofol inhibits prokaryotic voltage-gated Na+ channels by promoting activation-coupled inactivation”. Journal of General Physiology. In press.

Wang Y, Yang E, Wells M, Bondarenko V, Woll K, Carnevale V, Granata D, Klein M, Eckenhoff R, Dailey W, Covarrubias M, Tang P, and Xu Y. “Propofol Inhibits the Voltage-Gated Sodium Channel NaChBac at Multiple Sites”. Journal of General Physiology. In Press.


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Brittany Charsar
brittany.charsar@jefferson.edu

 

 

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Undergrad   University of Pittsburgh, BS, 2013
Year   MD/PhD 6, JGSBS-4
Mentor   Angelo Lepore, PhD
PhD Program

Research Interests
 

Neuroscience

Currently, I am investigating strategies to restore independent inspiratory breathing after cervical spinal cord injury. In the future, I would like to pursue clinical training in pediatric neurology and a research career studying leukodystrophies and white matter disorders in children.

Hobbies/Interests   My main interest outside of science is my dog, Thor. I also enjoy the Wissahickon trails and a good book.
Favorite Places/Things
to Do in Philadelphia
  Exploring the food scene in Philly is my favorite thing to do when I’m not in the lab or studying. I especially like all the BYOB gems throughout the city.
Honors/Awards   Ruth L. Kirschstein NRSA Pre-Doctoral F30 Fellowship
Neurodevelopmental Disabilities Scholarship, Child Neurology Foundation
Trainee Professional Development Award, Society for Neuroscience
Grant-In-Aid of Research Award, Sigma Xi1st Place Graduate Student Poster Award, 37th Meeting of the Philadelphia Chapter of the Society for Neuroscience, 2018
1st Place Graduate Student Poster Award, 36th Meeting of the Philadelphia Chapter of the Society for Neuroscience, 2017
Outstanding Poster Prize, TJU’s Sigma Xi Student Research Day, 2017
Outstanding Poster Prize, TJU’s Sigma Xi Student Research Day, 2016
The Fredric Rieders Renaissance Foundation Graduate Student Recognition Award
Adelaide M. Delluva Student Travel Award, Association for Women in Science, Philadelphia
Hobart Amory Hare Medical Honor Society, Thomas Jefferson University
Phi Beta Kappa Honor Society, University of Pittsburgh
Amgen Scholars Summer Undergraduate Research Program at the University of California, Berkeley
The Norman H. Horowitz Undergraduate Research Fellowship, University of Pittsburgh
The Samuel D. Colella Award for Summer Undergraduate Research, University of PittsburghOutstanding Freshman Biology Award, University of Pittsburgh
 Publications  

Charsar BA, Goldberg EM. Polymicrogyria and intractable epilepsy in siblings with Knobloch syndrome and homozygous mutation of COL18A1. Pediatric Neurology. 2017. DOI: 10.1016/j.pediatrneurol.2017.08.003.

Charsar BA, Urban MW, Lepore AC. Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. Experimental Neurology 2016. DOI: 10.1016/j.expneurol.2016.08.009.

Coombes JL, Charsar BA, Han SJ, Halkias J, Chan SW, Koshy AA, Striepen B, Robey EA. Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread. Proceedings of the National Academy of Sciences. 2013; 110:1913-1922.

Hainer SJ, Charsar BA, Cohen SB, Martens JA. Identification of spt16 mutants that are defective for transcription-coupled nucleosome occupancy in Saccharomyces cerevisiaeG3: Genes, Genomics, and Genetics. 2012; 2:555-567.


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Rogan Magee
rogan.magee@jefferson.edu

 

 

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Undergrad   St. Olaf College, BS, 2013
Year   MD/PhD 6, JGSBS-4
Mentor   Isidore Rigoutsos, PhD
PhD Program

Research Interests
 

Neuroscience

My long-term interests involve leveraging bioinformatic, high throughput “-omic”, and machine learning approaches in the research of neuropsychiatric disorders.

Hobbies/Interests   I love both playing and watching soccer and basketball, hiking and camping, the board game Diplomacy, and playing guitar. I’m also extremely passionate about extending my list of movies and TV shows watched to infinity and beyond.
Favorite Places/Things
to Do in Philadelphia
  In free time, I like to: run the Schuylkill river trail, catch a 76ers or Union game, walk around the art museum, get lost in Reading Terminal Market, or try out one of Philly’s many amazing restaurants.
Honors/Awards   Phi Beta Kappa, Distinction in Computer Science at St. Olaf College, Fredric Rieders Family Renaissance Foundation Graduate Student Recognition Award 2017, Hobart Amory Hare Honor Society, Sigma Xi Research Day Student Poster Award 2018
 Publications  

Pliatsika, V, Loher, P, Magee, R, Telonis, AG, Londin, E, Shigematsu, M, Kirino, Y, Rigoutsos, I. MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects. Nucleic Acids Res. 2018; 46 (D1):D152-D159. doi: 10.1093/nar/gkx1075. PubMed PMID:29186503 PubMed Central PMC5753276.

Pliatsika, V, Loher, P, Magee, R, Telonis, AG, Londin, E, Shigematsu, M, Kirino, Y, Rigoutsos, I. MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects. Nucleic Acids Res. 2018; 46 (D1):D152-D159. doi: 10.1093/nar/gkx1075. PubMed PMID:29186503 PubMed Central PMC5753276.

Magee, R, Telonis, AG, Cherlin, T, Rigoutsos, I, Londin, E. Assessment of isomiR Discrimination Using Commercial qPCR Methods. Noncoding RNA. 2017; 3 (2): doi: 10.3390/ncrna3020018. PubMed PMID:28730153 PubMed Central PMC5514785.

Telonis, AG, Magee, R, Loher, P, Chervoneva, I, Londin, E, Rigoutsos, I. Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types. Nucleic Acids Res. 2017; 45 (6):2973-2985. doi: 10.1093/nar/gkx082. PubMed PMID:28206648 PubMed Central PMC5389567.

Magee, R, Loher, P, Londin, E, Rigoutsos, I. Threshold-seq: a tool for determining the threshold in short RNA-seq datasets. Bioinformatics. 2017;33 (13):2034-2036. doi: 10.1093/bioinformatics/btx073. PubMed PMID:28203700 PubMed Central PMC5870860.


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Sean O'Sullivan
sjo003@jefferson.edu

 

 

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Undergrad   University of Pittsburgh, BS, 2010
Year   MD/PhD 6, JGSBS-4
Mentor   James Schwaber, PhD
PhD Program

Research Interests
 

Neuroscience

I am interested in the neurochemical basis of emotions and how those emotions influence behavior. I currently study this phenomenon in drug addiction.

Hobbies/Interests   Ice hockey, yoga
Favorite Places/Things
to Do in Philadelphia
  Read a book in Old City, Run the Art Museum steps, see live music
Honors/Awards    
 Publications   Park, J, Zhu, H, O’Sullivan, S, Ogunnaike, BA, Weaver, DR, Schwaber, JS, Vadigepalli, R. Single-cell transcriptional analysis reveals novel neuronal phenotypes and interaction networks involved in the central circadian clock. 2016. Frontiers in Neuroscience, 10, 481

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Benjamin Yang
benjamin.yang@jefferson.edu

 

 

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Undergrad   Lehigh University, BS, 2011
Year   MD/PhD 6, JGSBS-4
Mentor   Le Ma, PhD
PhD Program

Research Interests
 

Neuroscience

I study the role of microtubule-associated proteins in determining axon morphology during development.

Hobbies/Interests   Going to restaurants, watching movies, video games, board games like Diplomacy. Ancient history and pointless trivia (the two things are related actually). I like puns too.
Favorite Places/Things
to Do in Philadelphia
  Going to Reading Terminal and getting lots of food and getting annoyed by all the slow walkers.
Honors/Awards   Phi Beta Kappa, President’s Scholarship
 Publications  

Tymanskyj, S. R., Yang, B., Falnikar, A., Lepore, A. C., & Ma, L. (2017). MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglia Neurons. Journal of Neuroscience, 3260-16. PMCID: PMC5299575

Yang, B., Curran, B.M., & Tymanskyj, S.R. (2017). A Role for AnkyrinG in Maturation and Maintenance of the Nodes of Ranvier. Journal of Neuroscience, 5796-5797.


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Vibol Heng
vibol.heng@jefferson.edu

 

 

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Undergrad   Yale University, BS, 2014
Year   MD/PhD 5, JGSBS-3
Mentor   Richard J. Smeyne, PhD
PhD Program

Research Interests
 

Neuroscience

Neurodegeneration, Neurodevelopment, Environmental Enrichment, Social Isolation.

Hobbies/Interests   Travel, Foods, Puzzles, Soccer, Billiards, Learning new language  
Favorite Places/Things
to Do in Philadelphia
  Get foods/ice-cream/bubble tea in Chinatown, visit the awesome museums on the Benjamin Franklin Parkway, walk around City Hall, Penn’s Landing and Spruce Street Harbor, run along the Schuylkill River trail, play pool at Buffalo Billiards.
Honors/Awards  

Hobart Amory Hare Honor Society, Pathology Honor Society, 1st rank in Neuroscience Course, Honorable mention in the 9th Annual Annenberg Anatomy Competition.

Undergraduate: Friends of Todai Global Leadership Award, Science, Technology, and Research Scholar (STARS II) research fellowship, Yale College Dean’s Research fellowship, Charles E. Jones Scholarship

 Publications  

A.T. Issa, K. Miyata, V. Heng, K.D. Mitchell, A.V. Derbenev. (2012). Increased neuronal activity in the OVLT of Cyp1a1-Ren2 transgenic rats with inducible Ang II-dependent malignant hypertension. Neuroscience Letters, 519 (1), 26–30.

C. Kubera, A.L. Hernandez, V. Heng, A. Bordey. (2012). Transient mGlu5R inhibition enhances the survival of granule cell precursors in the neonatal cerebellum. Neuroscience, 219 (6), 271–279.


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Jeffrey Rappaport
jar026@jefferson.edu

 

 

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Undergrad   University of Maryland - College Park, BS, 2014
Year   MD/PhD 5, JGSBS-3
Mentor   Scott Waldman, MD, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

Genetic and other early transformational events in colon cancer

Hobbies/Interests   Gardening, woodworking, fostering kittens and pawning them off on co-workers
Favorite Places/Things
to Do in Philadelphia
  Saturday morning farmer’s market in Clark Park
Honors/Awards   Pre-doctoral Fellowship in Pharmacology/Toxicology - PhRMA Foundation (2017)
Dubbs Scholar MD/PhD Fellowship Award – Thomas Jefferson University (2014)
Undergraduate Researcher of the Year Award – University of Maryland (2014)
HHMI Undergraduate Research Fellowship – University of Maryland (2012)
Biomedical Engineering Summer Internship Program (BESIP) Fellowship – NIH (2012)
Solar Decathlon Competition, 1st Place Entry (“WaterShed”) – US Department of Energy (2011)
Banneker-Key Full Academic Scholarship – University of Maryland (2009)
Maryland Distinguished Scholar Academic Scholarship – State of Maryland (2009)
 Publications  

Kraft CL, Rappaport JA, Snook AE, Pattison AM, Lynch JP, Waldman SA. GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress. Oncotarget 2017;8:102923-102933.

Li P, Wuthrick E, Rappaport JA, Kraft CL, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C signaling opposes the acute radiation-induced GI syndrome. Cancer Res 2017;77:5095-5106. Cover article

Aka AA*, Rappaport JA*, Pattison AM, Sato T, Snook AE, Waldman SA. Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. Expert Rev Clin Pharmacol 2017;10:549-557. *Authors contributed equally

Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA. Intestinal enteroids model guanylate cyclase C-dependent secretion induced by heat-stable enterotoxins. Infect Immun 2016;84:3083-91.

Rappaport J*, Manthe RL*, Solomon M, Garnacho C, Muro S. A comparative study on the alterations of endocytic pathways in multiple lysosomal storage disorders. Mol Pharm 2016;13:357-368. *Authors contributed equally

Rappaport J, Papademetriou J, Muro S. Drug Delivery Through the Endo-Lysosomal Route. In: Drug Delivery Across Physiological Barriers, Muro S. (Ed.) Pan Stanford Publishing. 2016

Rappaport J, Manthe RL, Garnacho C, Muro S. Altered clathrin-independent endocytosis in type A Niemann-Pick disease cells and rescue by ICAM-1-targeted enzyme delivery. Mol Pharm 2015;12:1366-1376.

Rappaport J, Garnacho C, Muro S. Clathrin-mediated endocytosis is impaired in type A-B Niemann-Pick disease model cells and can be restored by ICAM-1-mediated enzyme replacement. Mol Pharm 2014;11:2887-95.

Hsu J, Rappaport J, Muro S. Specific binding, uptake, and transport of ICAM-1-targeted nanocarriers across endothelial and subendothelial cell components of the blood-brain barrier. Pharm Res 2014;31:1855-66.


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Noor Shaik
nxs062@jefferson.edu

 

 

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Undergrad   Villanova University, BSH, BS, BA, 2014
Year   MD/PhD 5, JGSBS-3
Mentor   Ulhas Naik, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

Our lab overall focuses on the role of platelets in cardiovascular disease. More specifically, I’m investigating the role of platelets in stroke and remote organ injury.

Hobbies/Interests   Volunteering at the pediatric department, spending time with family and friends, reading, making no-bake desserts
Favorite Places/Things
to Do in Philadelphia
  Museum hopping/visiting the amazing historical landmarks scattered around the city; Having brunch with friends (V Street is my favorite place so far)
Honors/Awards   National Pathology Honor Society (2016)
Hobart Amory Hare Medical Honor Society (2016)
Sigma Xi Poster Award (2018)
JCBS Alumni Association Travel Fellowship Award (2018)
 Publications  

Iosue, C. L., Attanasio, N., Shaik, N. F., Wykoff, D. D. (2016). Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrata. PLoS ONE, 11(3). PMC4807840. (Undergraduate)

Nahas, J.V., Iosue, C. L., Shaik, N. F., and Wykoff, D. D. (2018) Dynamic Changes in Yeast Phosphatase Families Allow for Specialization in Phosphate and Thiamine Starvation. G3 (Bethesda), Epub. PMID: 29748198 (Undergraduate)


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John Flickinger
jcf003@jefferson.edu

 

 

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Undergrad   University of Pittsburgh, BS, 2013
Year   MD/PhD 4, JGSBS-2
Mentor   Adam Snook, PhD
PhD Program

Research Interests
 

Immunology & Microbial Pathogenesis

Immunology, cancer immunology, immunotherapy

Hobbies/Interests   Cooking, fingerstyle guitar, running
Favorite Places/Things
to Do in Philadelphia
  Trying new restaurants, running along the Schuylkill River
Honors/Awards   NIH Postbaccalaureate Intramural Research Training Award
University of Pittsburgh Scholar
Ossip Award for Excellence in Undergraduate Writing
 Publications  

Flickinger, J.C., Jr., Rodeck, U., Snook, A.E. 2018. Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress. Vaccines (6): 48.

Magee, M.S., Abraham, T.S., Baybutt, T.R., Flickinger, J.C., Ridge, N.A., Marszalowicz, G.P., Prajapati, P., Hersperger, A.R., Waldman, S.A. and Snook, A.E. 2018. Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. Cancer immunology research 6(5):509-516.

Kwong, B., Rua, R., Gao, Y., Flickinger, J., Wang, Y., Kruhlak, M.J., Zhu, J., Vivier, E., McGavern, D.B. and Lazarevic, V. 2017. T-bet-dependent NKp46(+) innate lymphoid cells regulate the onset of TH17-induced neuroinflammation. Nature Immunology 18(10), pp. 1117–1127.

Leeman JE, Flickinger JC Jr, Clump DA, Wegner RE, Heron DE, Burton SA, Mintz AH. Detection and Treatment of Small Brain Metastases Resulting from Renal Cell Carcinoma Predict Improved Survival After Stereotactic Radiosurgery.  2012. Journal of Radiation Oncology 7:107.

Flickinger JC Jr, Kim H, Kano H, Greenberger JS, Arai Y, Niranjan A Lunsford LD, Kondziola D, Flickinger JC Sr. 2012. Do Carbamazepine, Gabapentin, or Other Anticonvulsants Exert Sufficient Radioprotective Effects to Alter Responses from Trigeminal Neuralgia Radiosurgery? Int J Radiat Oncol Biol Phys. 15; 83(4): e501-6

Kim H, Bernard ME, Flickinger J, Epperly MW, Wang H, Dixon TM, Shields D, Houghton F, Zhang X, Greenberger JS. 2011. The Autophagy Inducing Drug Carbamazepine is a Radiation Protector and Mitigator. Int J Radiat Biol (10): 1052-60.


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Josh  Barton
jxb471@jefferson.edu

 

 

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Undergrad   University of Delaware, BS, 2016
Year   MD/PhD 3, JGSBS-1
Mentor   TBD
PhD Program

Research Interests
 

TBD

I’d really like to develop a therapy in the lab for patients that I work with in the clinic. For neurology, in particular, there are a lot of people suffering from diseases with no prospects for improvement, and I’d love to give them some hope. I think our understanding of the brain is going to grow and change drastically during our lifetime and I’d like to be part of figuring that out.
Hobbies/Interests   Cooking, Golf, Disc Golf, Animals, Any kind of game, and any kind of music
Favorite Places/Things
to Do in Philadelphia
  Music Bingo at Manny Brown’s on South St, Chilling with animals at the Zoo, Every booth at Reading Terminal Market
Honors/Awards   Biological Sciences Undergraduate Research Award (University of Delaware), Delaware Governor’s Bioscience Fellowship Award (University of Delaware)
 Publications   Joshua Barton, Archana Siddam, Deepti Anand, Salil A Lachke, Molecular Characterization of Two Human Lens Epithelial Cell Lines and Their Suitability to Study Function of Cataract Genes, 2018: (In Preparation)

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Weelic Chong
weelic.chong@jefferson.edu

 

 

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Undergrad   Oberlin College, BA, 2015
Year   MD/PhD 3, JGSBS-1
Mentor   TBD
PhD Program

Research Interests
 

TBD

I am interested in neuroscience, specifically in how the nervous system interacts with the rest of the body, and in computation in general. My specific research interest has changed a lot (and multiple times) since entering medical school.

Hobbies/Interests   I like cooking, cycling and playing the guitar. This summer I’m hoping to grow a bonsai and a hydrangea bush.
Favorite Places/Things
to Do in Philadelphia
  I love watching the pups at the doggie park along the Schuylkill River Trail (it’s pronounced SKOOL-kul).
Honors/Awards   Elected into Phi Beta Kappa. May 2015
Awarded 1st place in the Sigma Xi Student Presentation Showcase 2015 (Undergraduate Division). Mar 2015
Elected into Sigma Xi, the Scientific Research Society. Mar 2015
Awarded the Robert Rich Grant from Oberlin College Robert Rich Foundation for outstanding research in the natural sciences. Mar 2015
Awarded the Pfizer-SOT Award to attend the Annual Society of Toxicology Meeting held in San Diego, CA (Mar 21 – Mar 26, 2015). Dec 2014  
 Publications  

Chong, W., Jiménez, J., McIIvin, M., Saito, M. A., & Kwakye, G. F. (2017). α-Synuclein Enhances Cadmium Uptake and Neurotoxicity via Oxidative Stress and Caspase Activated Cell Death Mechanisms in a Dopaminergic Cell Model of Parkinson’s Disease. Neurotoxicity research, 32(2), 231-246.

 


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Usman Baqai
usman.baqai@jefferson.edu

 

 

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Undergrad   Ursinus College, BS, 2017
Year   MD/PhD 2, JeffMD Phase 1, Year 2
Mentor   TBD
PhD Program

Research Interests
 

TBD

I am interested in translation cancer biology research. I like to understand molecular mechanisms of cancer that will help modulate future cancer therapies.

Hobbies/Interests   Outside of science I like to read science-fiction/fantasy books and play pick-up sports (give me any ball and I’ll chase after it). I also enjoy adventure trips with family and friends (hiking, camping, skiing, etc.).
Favorite Places/Things
to Do in Philadelphia
  I am a big fan of escape rooms and there are tons of new places in Philadelphia I have yet to explore. My favorite aspect of Philadelphia is being able to go to any corner of the street and finding a halal cart.
Honors/Awards    
 Publications    

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Lara Cheslow
lxc125@jefferson.edu

 

 

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Undergrad   Rutgers University, BA, 2014
Year   MD/PhD 2, JeffMD Phase 1, Year 2
Mentor   TBD
PhD Program

Research Interests
 

TBD

I’m interested in studying neurodegenerative diseases, and have spent just under four years researching the potential of ketamine to treat depression and the possibility of endogenous factors in the brain to treat multiple sclerosis. Learning new techniques is exciting and rewarding, but I really appreciate being trained on how to approach new scientific problems.

Hobbies/Interests   As soon as I save enough money, I spend it on traveling somewhere new, and tend to contract food poisoning at least once every trip. I enjoy hiking, reading, and spending a good amount of time drinking coffee with my family and alcohol with my friends.
Favorite Places/Things
to Do in Philadelphia
  One of my routine activities in Philly is Muay Thai, which I practice a few times a week in Philly. No official fighting yet, though. I also love browsing the Italian market for the deal of the day (like a bucket of tangerines for $1), and when money is decent, I splurge on the best cappuccinos in the city at Function Coffee Labs.
Honors/Awards   Graduated magna cum laude from Rutgers
 Publications  

Alvarez JI, Kebir H, Cheslow L, Larochelle C, Charabati M, Prat A. JAML mediates monocytes and CD8 T cell migrations across the brain endothelium. Ann Clin Transl Neurol. 2015 Sep 29;2(11):1032-7.

Cheslow L, Alvarez JI. Glial-endothelial crosstalk regulates blood–brain barrier function. Current Opinion in Pharmacology. 2016 Feb;26:39-46.


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Colleen Isabelle
colleen.isabelle@jefferson.edu

 

 

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Undergrad   Wellesley College, BA, 2013
Year   MD/PhD 2, JeffMD Phase 1, Year 2
Mentor   TBD
PhD Program

Research Interests
 

TBD

After graduating from Wellesley College, I spent four years in a pulmonary and critical care research laboratory at Brigham and Women’s Hospital as a research assistant.  I worked on several projects relating to acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury. During my graduate years I hope to continue in this field of research, but I am excited to explore the many research opportunities at Jefferson.

Hobbies/Interests   At Jefferson I am on the board of the JeffLGBTQ student group, which organizes lectures and events for the TJU community. I also volunteer in the hospital with JeffReads, a group that encourages early literacy by providing new parents with books for their babies and fulfills cuddling needs in the intensive care nursery. In my spare time, I enjoy exploring restaurants in Philly (especially Dim Sum) and spending time outdoors.
Favorite Places/Things
to Do in Philadelphia
  Spruce St. Harbor Park is a great place to go during the summer for music, food, and fun! I also live near the Kawaii Kitty Café, where you can grab a coffee and play with cats!
Honors/Awards   Phi Beta Kappa, Wellesley College Durant Scholar, The Klein Prize in Neuroscience 2013 at Wellesley College
 Publications  

Boudreault, F., Pinilla-Vera, M., Englert, J. A., Kho, A. T., Isabelle, C., Arciniegas, A. J., . . . Baron, R. M. (2017). Zinc deficiency primes the lung for ventilator-induced injury. JCI Insight, 2(11). doi:10.1172/jci.insight.86507

Englert, J. A., Macias, A. A., Amador-Munoz, D., Vera, M. P., Isabelle, C., Guan, J., . . . Baron, R. M. (2015). Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity. Anesthesiology, 123(2), 377-388. doi:10.1097/aln.0000000000000742


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Selin Isguven
sxi022@jefferson.edu

 

 

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Undergrad   Yale College, BS, 2015
Year   MD/PhD 2, JeffMD Phase 1, Year 2
Mentor   TBD
PhD Program

Research Interests
 

TBD

Past experience: Computational analysis, glucose metabolism, endocrinology;  Clinical research, acute kidney injury, acute interstitial nephritis, nephrology

Currently open to exploring different fields for my PhD.

Hobbies/Interests   Art and art history, traveling, photography.
Favorite Places/Things
to Do in Philadelphia
  I love trying new food (or revisiting old favorites) and going to art galleries or other cultural places. One of my favorites has been the Philadelphia Chinese Lantern Festival so far, which I believe is the largest one in the country!
Honors/Awards    
 Publications   Moledina, D. G., Isguven, S., McArthur, E., Thiessen-Philbrook, H., Garg, A. X., Shlipak, M., ... & Parikh, C. R. (2017). Plasma monocyte chemotactic protein-1 is associated with acute kidney injury and death after cardiac operations. The Annals of thoracic surgery, 104(2), 613-620.

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Haani Jafri
hxj014@jefferson.edu

 

 

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Undergrad   University of California, Berkeley, BA, 2015
Year   MD/PhD 2, JeffMD Phase 1, Year 2
Mentor   TBD
PhD Program

Research Interests
 

TBD

I’m primarily interested in neuroscience. I enjoy learning about the dynamics of synapses and neural circuits in different neurological states. Specifically, I want to study more about the neural circuit level basis for behavioral dysfunction exhibited in neurodevelopmental or neurodegenerative diseases such as Autism Spectrum Disorder or Alzheimer’s Disease.
Hobbies/Interests   I like to spend my time mostly outdoors which usually includes hiking, camping, or whatever activity I can do in nature. Sometimes when the Philly weather isn’t as nice to me, I’ll read a book, watch a movie, or play Settlers of Catan.
Favorite Places/Things
to Do in Philadelphia
  My opinion is that Philly is best known for its parks and its food. Favorite park: Wissahickon Valley. Favorite food: cheesesteaks from Ishkabibble’s.
Honors/Awards   I.L. Chaikoff Memorial Award (Berkeley)
 Publications   Hruska M, Henderson N, Le Marchand SJ, Jafri H, Dalva MB. (2018). Synaptic nanomodules underlie the organization and plasticity of spine synapses. Nat Neurosci. 21(5):671-682.

Elstrott J, Clancy KB, Jafri H, Akimenko I, Feldman DE. (2014). Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex. J Neurophysiol. 112(2):233-48.

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Tyler Alexander
tyler.alexander@jefferson.edu

 

 

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Undergrad   Swarthmore College, BA, 2017
University of Pennsylvania, MS, 2018
Year   MD/PhD 1 , JeffMD Phase 1, Year 1
Mentor   TBD
PhD Program

Research Interests
 

TBD

I am highly interested in the field of neuroscience. I have a broad interest in cellular and molecular as well as systems neuroscience with an emphasis on translational research. I am particularly excited by work in fields related to cell signaling and synaptogenesis, as they lead to an understanding of diseases and to therapies affecting neuronal circuitry.
Hobbies/Interests   I enjoy distance running and playing blues and jazz guitar. I am an avid reader and also like to cook.
Favorite Places/Things
to Do in Philadelphia
  Run along the Schuylkill River trail, tour Barnes and Philly’s other museums, and indulge at Reading Terminal Market.
Honors/Awards   Lang Opportunity Scholarship (Swarthmore College)
Excellence in Social Innovation Award (University of Pennsylvania)
Practicum Honors (University of Pennsylvania)
 Publications  

Arbuckle DS, Howard KP, Alexander T, Crouch C. (2017). Site-Directed Spin-Label EPR Spectroscopy of M2 Protein in Lipid Bilayers of Different Curvature Generation Propensity. Biophysical Journal 112(3): 505a.

Alexander T, McGovern S, Leary, M Nadkarni V, Abella BS, & Blewer AL. (2018). Abstract 27: Implications of Legislative Efforts on Layperson CPR Education. Circulation, 138 (Suppl 2), A27-A27. 2.27

Blewer AL, Alexander T. (2018, November). Implications of state-level CPR training initiatives on layperson CPR knowledge in the United States. Oral presentation at the AHA Science Symposium, Chicago, IL.

Alexander T, McGovern S, Leary M, Nadkarni V, Abella BS, Blewer AL. (2018). Implications of legislative efforts on layperson CPR training. (Manuscript in Progress)

Das S, Sheng M, Alexander T, Baldassari MP, Boorman DW, Jallo J, Heller J, Prasad S, Sharan AD, Harrop JS, Rodgers K, Wu C, Madineni RA. (2018) Effect of Preoperative Opiate Dosage on Postoperative Length of Stay and Complications Following Elective Spinal Surgery. (Manuscript in Progress)

 

 


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Signe Caksa
signe.caksa@jefferson.edu

 

 

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Undergrad   Brown University, BSc, 2016
Year   MD/PhD 1, JeffMD Phase 1, Year 1
Mentor   TBD
PhD Program

Research Interests
 

TBD

As an undergraduate student at Brown University, I conducted research that examined chemoresistance and metastasis in ovarian cancer. I also worked as a clinical research coordinator at MGH for two years, studying bone health in a variety of patient populations. For my graduate work, I am currently interested in pursuing translational research in cancer biology, with an emphasis on cell signaling, cancer genetics, and cancer cell metabolism.
Hobbies/Interests   In my spare time, I like reading and writing, and taking photographs. I also enjoy hiking, running, being outdoors, and traveling. I am also an avid polo player, having started playing as an undergraduate student.
Favorite Places/Things
to Do in Philadelphia
  Philadelphia has some great art museums, the Rodin Museum and Barnes Foundation being favorites of mine. As a newcomer to the city, I still have a lot of exploring to do!
Honors/Awards    
 Publications  

Unnikrishnan, G., Xu, C., Popp, K.L., Hughes J.M., Caksa, S., Guerriere K.I., Ackerman, K.E., Bouxsein, M.L., Reifman, J. Regional variation of bone density, microarchitectural parameters, and elastic moduli in the ultradistal tibia of young black and white men and women. Bone. 2018 Jul; 112: 194-201. DOI: 10.1016/j.bone.2018.05.004.

Rozental, T.D., Walley, K.C., Demissie, S., Caksa, S., Martinez-Betancourt, A., Parker, A. M. Tsai, J. N., Yu, E. W., Bouxsein, M. L. Bone material strength index as measured by impact microindentation in postmenopausal women with distal radius and hip fractures. Journal of Bone and Mineral Research. 2018 Apr; 33(4): 621-626. DOI: 10.1002/jbmr.3338

Mitchell, D.M., Caksa S., Yuan A., Bouxsein M.L., Burnett-Bowie, S.M., Misra M. Trabecular bone morphology correlates with skeletal maturity and body composition in healthy adolescent girls. Journal of Clinical Endocrinology & Metabolism. 2018 Jan; 103(1): 336-345. DOI: 10.1210/jc.2017-01785

Popp K.L., Hughes J.M., Martinez-Betancourt A., Scott M., Turkington V., Caksa S., Guerriere K.I., Ackerman K.E., Xu C., Unnikrishnan G., Reifman J., Bouxsein M.L. Bone mass, microarchitecture and strength are influenced by race/ethnicity in young adult men and women. Bone. 2017 Oct; 103: 200-208. DOI: 10.1016/j.bone.2017.07.014