PhD, Purdue University (Cancer Cell Biology) - 2006
Fellowship
Postdoctoral Fellow, Harvard Medical School
Guru Chandramouly, PhD
Research Instructor, Department of Biochemistry & Molecular Biology
Contact Information
Research Instructor, Department of Biochemistry & Molecular Biology
Education
Publications
- Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia
- RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors
- PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
- Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM
- Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors