Erik Debler, PhD
Assistant Professor
Contact
1020 Locust Street
Room 411F JAH
Philadelphia, PA 19107
215-503-4596
215-923-2117 fax
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Erik Debler, PhD
Assistant Professor
Research Interests
Structural biology, x-ray crystallography, chromatin, epigenetics, gene regulation, bromodomain, chromatin modifying enzymes, parasitology, trypanosomes, sleeping sickness, chemical biology, drug discovery
Education
PhD, Biophysics, The Scripps Research Institute, La Jolla - 2007
MS, Biochemistry, Freie Universitat Berlin, Germany - 2002
Fellowship
Damon Runyon Cancer Research Foundation Postdoctoral Fellowship, Rockefeller University
Most Recent Peer-Reviewed Publications
- Structural enzymology of cholesterol biosynthesis and storage
- Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment
- Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
- Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme)
- Substrate Affinity and Specificity of the ScSth1p Bromodomain Are Fine-Tuned for Versatile Histone Recognition