Dmitry Temiakov, PhD
Professor
Contact
1020 Locust Street
Jefferson Alumni Hall, Room 425E
Philadelphia, PA 19107
Dmitry Temiakov, PhD
Professor
Expertise & Research Interests
My laboratory uses structural biology in combination with biochemical approaches to study the structure and function of mitochondrial transcription machinery. We are interested in deciphering molecular mechanisms of transcription initiation, elongation, termination and anti-termination, as well as replication primer synthesis by mitochondrial RNA polymerase. We also aim to understand the interplay between transcription and replication machineries in mitochondria of normal and cancer cells.
Education
PhD, Molecular Biology, Institute for Genetics, Russian Academy of Science, Moscow, Russia - 1996
MS, Microbiology, Mendeleev University of Chemical Technology, Moscow, Russia - 1993
Fellowship
SUNY Downstate Medical Center, Department of Microbiology and Immunology, Brooklyn, NY - 1997-2002
Most Recent Peer-Reviewed Publications
- Structural basis for DNA proofreading
- Molecular basis for maternal inheritance of human mitochondrial DNA
- Mesoscale structure–function relationships in mitochondrial transcriptional condensates
- Mechanisms of mitochondrial promoter recognition in humans and other mammalian species
- Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL
Awards
- Excellence in Research Award, NJ Health Foundation, 2015 and 2013
- Faculty Research Achievement Award, Rowan University, 2015
- Postdoctoral Fellowship Dean's Initiative in Research, SUNY Downstate medical Center, Brooklyn, NY, 1999, 2000, 2001