Targeting Akt Kinase and PKA Dephosphorylation Mechanisms To Heal Skin, Lung and Radiation Wounds. My laboratory focuses on the understanding the mechanisms that regulate Akt kinase and Protein Kinase A (PKA). Our studies of an inherited mutation for Akt2 protein kinase that causes insulin resistance led to the discovery of a series of molecular switches that regulate Akt dephosphorylation. The implications and importance of this work, as applicable to general protein kinases, was published in PNAS and discussed in perspective articles. More project information found on my Research Site.
Tung Chan, PhD
Assistant Professor of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Contact Information
Assistant Professor of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Research & Clinical Interests
Education
PhD University of Calgary, Alberta, Canada 1993
Publications
- Qualitative beta-2-adrenoceptor signaling in the regulation of human airway epithelia mucin and cytokine production
- AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology
- A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation
- Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
- MiR-146a targets Fos expression in human cardiac cells