PhD, University of Pennsylvania, Philadelphia, PA - 2021
Ryan Cupo, PhD
Assistant Professor, Department of Pathology & Genomic Medicine
Contact Information
1020 Locust Street
527A Jefferson Alumni Hall
Philadelphia, PA 19107
Assistant Professor, Department of Pathology & Genomic Medicine
Education
Publications
- The mitochondrial intermembrane space nuclease Nuc1 (endonuclease G) prevents mitophagy-mediated mtDNA escape in yeast
- Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB
- Erratum: Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy (Cell Reports (2025) 44(1), (S2211124724015560), (10.1016/j.celrep.2024.115205))
- Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
- Decoding Skd3 (Human CLPB): A Mitochondrial Protein Disaggregase Critical for Human Health
Research & Clinical Interests
My research is in how mitochondria resolve stress via cellular signaling pathways, organellar stress responses, and protein quality control machinery using a variety of cell biology and biochemical techniques. Many components of the mitochondrial quality control machinery are mutated in disease; insufficient stress responses can lead to a sensitivity to apoptosis and drive neurodegenerative disorders, whereas excess mitochondrial quality control capacity can contribute to oncogenesis and drive chemoresistance.