Dr. Knudsen Karen E. Knudsen, PhD

Contact Dr. Knudsen

233 South 10th Street
Suite 1008
Philadelphia, PA 19107

(215) 503-8574
fax

Research and Clinical Interests
Translational prostate cancer research, cell cycle control, hormonal control of gene transcription, chromatin remodeling.

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Publications

Most recent Peer-reviewed Publications

  1. Genomic prostate cancer classifier predicts biochemical failure and metastases in patients after postoperative radiation therapy
  2. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer
  3. Transcriptional roles of PARP1 in cancer
  4. AR function in promoting metastatic prostate cancer
  5. Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells
  6. AMPed up to treat prostate cancer: Novel AMPK activators emerge for cancer therapy
  7. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  8. USP22 regulates oncogenic signaling pathways to drive lethal cancer progression
  9. Targeting cell cycle and hormone receptor pathways in cancer
  10. A hormone-DNA repair circuit governs the response to genotoxic insult
  11. Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition
  12. IGF2 revs the steroidogenesis engine
  13. The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)
  14. Ex vivo culture of human prostate tissue and drug development
  15. Molecular pathogenesis and progression of prostate cancer
  16. Aberrant BAF57 signaling facilitates prometastatic phenotypes
  17. The role of tumor suppressor dysregulation in prostate cancer progression
  18. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes
  19. Dual roles of PARP-1 promote cancer growth and progression
  20. Cyclin D1 goes metabolic: Dual functions of cyclin D1 in regulating lipogenesis

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