Dr. Knudsen Karen E. Knudsen, PhD

Contact Dr. Knudsen

233 South 10th Street
Suite 1008
Philadelphia, PA 19107

(215) 503-8574
fax

Research and Clinical Interests
Translational prostate cancer research, cell cycle control, hormonal control of gene transcription, chromatin remodeling.

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Publications

Most recent Peer-reviewed Publications

  1. Genomic prostate cancer classifier predicts biochemical failure and metastases in patients after postoperative radiation therapy
  2. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer
  3. Transcriptional roles of PARP1 in cancer
  4. Beyond DNA repair: DNA-PK function in cancer
  5. AR function in promoting metastatic prostate cancer
  6. Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells
  7. AMPed up to treat prostate cancer: Novel AMPK activators emerge for cancer therapy
  8. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  9. USP22 regulates oncogenic signaling pathways to drive lethal cancer progression
  10. Targeting cell cycle and hormone receptor pathways in cancer
  11. A hormone-DNA repair circuit governs the response to genotoxic insult
  12. Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition
  13. IGF2 revs the steroidogenesis engine
  14. The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)
  15. Ex vivo culture of human prostate tissue and drug development
  16. Molecular pathogenesis and progression of prostate cancer
  17. Aberrant BAF57 signaling facilitates prometastatic phenotypes
  18. The role of tumor suppressor dysregulation in prostate cancer progression
  19. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes
  20. Dual roles of PARP-1 promote cancer growth and progression

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