Philadelphia University + Thomas Jefferson University

Alnemri, Emad

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Emad Alnemri, PhD

Contact Dr. Alnemri

233 South 10th Street
BLSB 904
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Research and Clinical Interests

Molecular mechanisms of programmed cell death (apoptosis); Pattern recognition receptors and inflammasome activation in innate immune responses to molecular danger signals; role of mitochondria in survival, cell death and aging.

Publications

Most Recent Peer-Reviewed Publications

  1. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
  2. The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
  3. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  4. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
  5. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4
  6. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
  7. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015
  8. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function
  9. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy
  10. IKKα negatively regulates ASC-dependent inflammasome activation
  11. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome
  12. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
  13. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
  14. Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome
  15. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
  16. A novel role for the mitochondrial HTRA2/OMI protease in aging
  17. Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis
  18. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
  19. Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
  20. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection