Philadelphia University + Thomas Jefferson University

Alugupalli, Kishore

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Kishore Alugupalli, PhD

Contact Dr. Alugupalli

233 South 10th Street
Room 726 BLSB
Philadelphia, PA 19107

(215) 503-4554
(215) 503-4153 fax

Research and Clinical Interests

Immunology. B cell Memory - B1b Lymphocyte biology; Innate Immunity - Toll-like receptors and NOD-like receptors

B1b lymphocytes in T cell-independent memory:
Pathogenesis of infectious disease is not only determined by the virulence of the microbe but also by the immune status of the host. Vaccination is the most effective means to control infectious diseases. A hallmark of the adaptive immune system is the generation of B cell memory, which provides a long-lasting protective antibody response that is central to the concept of vaccination. Studies from our laboratory revealed a distinct function for B1b lymphocytes, a minor subset of mature B cells that closely resembles that of memory B cells in a number of aspects. In contrast to the development of conventional B cell memory, which requires the formation of germinal centers and T cells, the development of B1b cell-mediated long-lasting antibody responses occurs independent of T cell help. T cell-independent (TI) antigens are important virulence factors expressed by a number of bacterial pathogens, including those associated with biological threats. TI antigens cannot be processed and presented to T cells and therefore are known to possess restricted T cell-dependent (TD) immunogenicity. Nevertheless, specific recognition of TI antigens by B1b cells and the highly protective antibody responses mounted by them clearly indicate a crucial role for this subset of B cells. Understanding the mechanisms of long-term immunity conferred by B1b cells are among the major interests of my laboratory.

Publications

Most Recent Peer-Reviewed Publications

  1. Humoral Immunity in Mice Transplanted with Hematopoietic Stem Cells Derived from Human Umbilical Cord Blood Recapitulates That of Human Infants
  2. APRIL:TACI axis is dispensable for the immune response to rabies vaccination
  3. BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses
  4. Impaired B cell receptor signaling is responsible for reduced TACI expression and function in X-Linked immunodeficient mice
  5. Efficient B cell responses to Borrelia hermsii infection depend on BAFF and BAFFR but not TACI
  6. Deciphering the role of toll-like receptors in humoral responses to Borreliae
  7. Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever
  8. B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact
  9. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection
  10. T-cell-independent immune responses do not require Cxc ligand 13-mediated B1 cell migration
  11. IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae
  12. Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes
  13. Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice
  14. Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus
  15. B Cell Multitasking Is Required to Control Nematode Infection
  16. A distinct role for B1b lymphocytes in T cell-independent immunity
  17. Role of the innate immune system in autoimmune inflammatory demyelination
  18. Complement factor H-binding protein, a putative virulence determinant of borrelia hermsii, is an antigenic target for protective B1b lymphocytes
  19. The ArcA regulon and oxidative stress resistance in Haemophilus influenzae
  20. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses