Philadelphia University + Thomas Jefferson University

Koh, Kyunghee

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Kyunghee Koh, PhD

Contact Dr. Koh

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 955-5905
(215) 503-4358 fax

Research and Clinical Interests

Sleep appears to serve important functions, but why we sleep and how sleep is regulated are not well understood. It is clear, however, that sleep is under circadian control. Our overall goal is to elucidate the molecular and cellular basis of sleep and circadian rhythms. Due to ease of genetic manipulation and molecular analysis, the fruit fly, Drosophila melanogaster, has emerged as a powerful model system for studying sleep and circadian rhythms. Our research strategy is to find Drosophila mutants with a strong and interesting sleep or circadian phenotype and identify the genetic, molecular, and cellular basis for the phenotype. Using this strategy, we have discovered several novel genes [e.g., jetlag (Koh et al, Science, 2006) and sleepless (Koh et al, Science, 2008; Wu et al, Nature Neuroscience, 2010)] and mutations affecting sleep and circadian rhythms. We also employ various genetic tools for targeted gene expression to define novel sleep circuits.

Publications

Most Recent Peer-Reviewed Publications

  1. Identification of octopaminergic neurons that modulate sleep suppression by male sex drive
  2. Regulation of sleep plasticity by a thermo-sensitive circuit in Drosophila
  3. Control of sleep by a network of cell cycle genes
  4. TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila
  5. WIDE AWAKE mediates the circadian timing of sleep onset
  6. Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic
  7. Cell-specific fine-tuning of neuronal excitability by differential expression of modulator protein isoforms
  8. Genetic and Anatomical Basis of the Barrier Separating Wakefulness and Anesthetic-Induced Unresponsiveness
  9. Dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and slowpoke channels
  10. Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant
  11. SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker
  12. An isoform-specific mutant reveals a role of PDP1ε in the circadian oscillator
  13. The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor
  14. The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting
  15. Identification of SLEEPLESS, a sleep-promoting factor
  16. A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila
  17. Molecular analysis of sleep:wake cycles in Drosophila
  18. A Drosophila model for age-associated changes in sleep:wake cycles
  19. JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS
  20. The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes