0B68 Pascal, John - Thomas Jefferson University - Thomas Jefferson University
jmp007

John M. Pascal, PhD

Contact Dr. Pascal

233 South 10th Street
Suite 804
Philadelphia, PA 19107

(215) 503-4596
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs
  2. The rise and fall of poly(ADP-ribose): An enzymatic perspective
  3. Discovery and structure-activity relationship of novel 2,3- dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2 h)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 Inhibitors
  4. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
  5. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  6. Selective phosphorylation modulates the PIP 2 sensitivity of the CaM-SK channel complex
  7. Structural implications for selective targeting of PARPs
  8. Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
  9. New players to the field of ADP-ribosylation make the final cut
  10. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation
  11. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
  12. Dual roles of PARP-1 promote cancer growth and progression
  13. Identification of the functional binding 05B4 pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels
  14. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1
  15. Structural basis for calmodulin as a dynamic calcium sensor
  16. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases
  17. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  18. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
  19. Purification of human PARP-1 and PARP-1 domains from escherichia coli for structural and biochemical analysis
  20. Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: Structural and functional insights into DNA-dependent PARP-1 activity
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