2982 Pascal, John - Thomas Jefferson University - Thomas Jefferson University
jmp007

John M. Pascal, PhD

Contact Dr. Pascal

233 South 10th Street
Suite 804
Philadelphia, PA 19107

(215) 503-4596
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. Discovery and structure-activity relationship of novel 2,3- dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2 h)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 Inhibitors
  2. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
  3. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  4. Structural implications for selective targeting of PARPs
  5. Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
  6. New players to the field of ADP-ribosylation make the final cut
  7. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation
  8. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
  9. Dual roles of PARP-1 promote cancer growth and progression
  10. Identification of the functional binding pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels
  11. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1
  12. Structural basis for calmodulin as a dynamic calcium sensor
  13. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  14. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases
  15. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
  16. Purification of human PARP-1 and PARP-1 domains from escherichia coli for structural and biochemical analysis
  17. Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: Structural and functional insights into DNA-dependent PARP-1 activity
  18. The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction
  19. The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1
  20. A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation (Journal of Biological Chemistry (2008) 283, (4105-4114))
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