Thomas Jefferson UniversitySidney Kimmel Medical College

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2013 Philadelphia Workshop
Friday, November 22, 2013

Keynote Speaker

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“Platelet Integrins and Their Adapters: Data vs. Dogma”

Sanford Shattil, M.D.
Distinguished Professor of Medicine
Chief, Division of Hematology-Oncology
Director, Hematology-Oncology Fellowship Program
University of California, San Diego

 

 

Schedule of Events

7:30-8:00 Welcome:  Registration and Breakfast
(Brent Auditorium)
7:55-8:05
Introductory remarks by Michael Holinstat, Ph.D.
8:00-10:00

Session #1:  Basic Science Studies in Hemostasis and Thrombosis
(Brent Auditorium)

Chairs:  Leonard Edelstein, Ph.D. (Jefferson) and Lubica Rauova, M.D., Ph.D. (CHOP)

8:05-8:20        ADAMTS13 Expressed in Platelets Offers Systemic Protection against Arterial Thrombosis and Therapeutic Benefits in Murine Models of Thrombotic Thrombocytopenic Purpura with Inhibitors. (Abstract #35)

Brandy Pickens
1*
, Yingying Mao1* and X. Long Zheng1,21Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia; 2Pathology and Laboratory Medicine, The University of PennsylvaniaRegulation of fatty acid metabolism requires
8:20-8:35       

TMEM16F Plays a Vital Role in Platelet Microparticle Generation and Thrombosis. (Abstract #9)

Ann-Desdemonia N. Fowajuh1, Debora K. Mukaz1, Dongjun Li1, Pani Apostolidis1, Aasma Khan1, Jeff Caplan2, Andrea Vortkamp3, and Donna S. Woulfe1.  1Department of Biological Sciences, University of Delaware; 2 Bio-Imaging Department, Delaware Biotechnology Institute; 3University of Duisberg-Essen

8:35-8:50       

TC21/R-Ras2 contributes to GPVI receptor signaling in platelets and thrombus stability.  (Abstract #26)

Sumalaxmi Janapati1,3, Carol Dangelmaier1,3, Dheeraj Bhavanasi1,3, Soochong Kim1,3, Satya P. Kunapuli1,3, and Lawrence E. Goldfinger2,3.  1Department of Physiology and Pharmacology and 2Anatomy and Cell Biology, 3Sol Sherry Thrombosis Research Center, Temple University School of Medicine

8:50-9:05       

RhoG Regulates GPVI/FcRg-mediated Platelet Activation and Thrombus Formation.  (Abstract #25)

Soochong Kim, Carol Dangelmaier, Dheeraj Bhavanasi, Shu Meng, Hong Wang, Lawrence E. Goldfinger, and Satya P. Kunapuli.  Department of Physiology, Department of Pharmacology, Department of Anatomy and Cell Biology, and the Sol Sherry Thrombosis Research Center, Temple University School of Medicine

9:05-9:20       

Functional 12-lipoxygenase for prevention of platelet activation and thrombosis. (Abstract #33)

Jennifer Yeung1,2, Pilar Fernandez-Perez1,2, Joanne Vesci1,2, Theodore R Holman3 and Michael Holinstat1,21Cardeza Foundation for Hematologic Research Medicine, Thomas Jefferson University; 2Department of Medicine, Thomas Jefferson University; 3Chemistry and Biochemistry, University of California Santa Cruz

9:20-9:35       

Physiologic platelets released from human megakaryocytes following infusion into mice: Potential role of macrophages in thrombopoiesis.  (Abstract #41)

Yuhuan Wang1, Vincent Hayes1, Deborah L. French2,4, and Mortimer Poncz1,31Department of Pediatrics1 and Pathology and Laboratory Medicine2, Children’s Hospital of Philadelphia; Department of Pediatrics3 and Pathology and Laboratory Medicine4, Perelman School of Medicine at the University of Pennsylvania.

9:35-10:00      Coffee Break: Outside Brent Auditorium
10:00-11:30   

Session #2:  Clinical Studies in Hemostasis and Thrombosis(Brent Auditorium)

Chairs:  Timothy Stalker, Ph.D. (UPenn) and Long Zhang, M.D, Ph.D. (CHOP)

10:00-10:15   

Tolerance induction to FIX Padua with AAV liver gene transfer in inhibitor-prone hemophilia B dogs. (Abstract #2)

JM. Crudele, J Finn*, NB Martin*, JI Siner*, Y Chen*, S Zhou*, G Niemeyer, CD Lothrop, F Mingozzi*, KA High*†, VR Arruda*†.   *CHOP, University of Pennsylvania,University of Alabama.

10:15-10:30   

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. (Abstract #18)

Sang H. Min1, Aae Suzuki1 , Timothy J. Stalker1, Jessica F. Guzman1, Liang Zhao1, Lurong Lian1, Matthew J. Riese1, Rohan Joshi1, Ronghua Meng2, Gary Koretzky1, Michael S. Marks2, John K. Choi3, and Charles S. Abrams1.

Departments of 1Medicine and 2Pathology at the University of Pennsylvania School of Medicine and 3Hematopathology, St. Jude Children’s Research Hospital

10:30-10:45

Deuterium-Hydrogen Exchange Coupled with Mass Spectrometry Identified a Novel Autoantibody Binding Epitope and Substrate Recognition Site in ADAMTS13 Protease.  (Abstract #34)

Veronica C. Casina1, Wenbing Hu2, Hayley Hanby1, Donald L. Siegel3, S. Walter Englander2 and X. Long Zheng1,31Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia; 2Biochemistry and Molecular Biophysics, University of Pennsylvania; 3Pathology and Laboratory Medicine, The University of Pennsylvania

10:45-11:00   

ZFN Mediated Targeting of Albumin “Safe Harbor” Results in Therapeutic Levels of Human Factor VIII In a Mouse Model of Hemophilia A.  (Abstract #38)

Xavier M. Anguela1,2, Rajiv Sharma1, Yannick Doyon3, Thomas Wechsler3, David E. Paschon3, Robert J Davidson1, Shangzhen Zhou1, Philip D. Gregory3, Michael C. Holmes3, Edward J. Rebar3, and Katherine A. High1,21Hematology, The Children's Hospital of Philadelphia; 2Howard Hughes Medical Institute, The Children's Hospital of Philadelphia; 3Sangamo Biosciences Inc.

11:00-11:15   

Racial Differences in Thrombin-Induced Human Platelet PAR4 Reactivity may Contribute to Racial Differences in Thrombotic Risk. (Abstract #37)

Leonard C. Edelstein1, Lukas M. Simon2, Raúl Teruel Montoya1, Michael Holinstat1, Edward S. Chen2, Angela Bergeron2, Xianguo Kong1, Srikanth Nagalla1, Narla Mohandas3, David E. Cohen4, Jing-fei Dong5, Chad Shaw2 and Paul F. Bray1  1 Thomas Jefferson University, The Cardeza Foundation for Hematologic Research and the Department of Medicine, Jefferson Medical College; 2 Departments of Molecular and Human Genetics and Medicine, Baylor College of Medicine; 3New York Blood Center, 4Harvard Medical School, 5 Puget Sound Blood Center

11:15-11:30   

Effect of Age and Gender on Human Platelet mRNA and microRNA Levels.  (Abstract #11)

Lukas M. Simon1, Leonard C. Edelstein2, Srikanth Nagalla2, Angela Bergeron3, Edward S. Chen1, Xianguo Kong2, Lin Ma2, Satya Kunapuli4, Michael Holinstat2, Steven E. McKenzie2, Jing-fei Dong4, Chad Shaw1,5 and Paul F. Bray, MD21Departments of Molecular and Human Genetics and Medicine, Baylor College of Medicine; 1Thomas Jefferson University, The Cardeza Foundation for Hematologic Research and the Department of Medicine, Jefferson Medical College; 3Baylor College of Medicine; 4Puget Sound Blood Center; 5Department of Statistics, Rice University

11:30-11:45   

Toll-Like Receptor 4 Regulates Tissue Factor Procoagulant Activity In Response To Hyperglycemia And Hyperinsulinemia: Differential Regulation In Healthy Subjects And Patients With Type1 And Type 2 Diabetes Mellitus.  (Abstract #10)

Anamika Singh1, Guenther Boden2, A. Koneti Rao1,3.  Sol Sherry Thrombosis Research Center1, Division of Endocrinology2 and Division of Hematology3 and Department of Medicine, Temple University School of Medicine

11:45-1:15      Poster Session: Mezzanine
12:15-1:15 Lunch: Eakins Lounge (1st Floor JAH)
1:15-2:15 Keynote Speaker
Introduction:  Steven E. McKenzie, M.D., Ph.D.

“Platelet Integrins and Their Adapters: Data vs. Dogma”

Sanford J. Shattil, M.D.

Chief, Hematology-Oncology Division
Distinguished Professor of MedicineUniversity of California San Diego
2:15-2:30        Coffee Break: Outside Brent Auditorium
2:30-4:15        Session #3:  Coagulation, HIT, and Fibrinolysis
Chairs:  Rodney M. Camire, Ph.D. (CHOP) and Ulhas Naik, Ph.D. (Delaware)
2:30-2:45

Clot Contraction: Compression of Erythrocytes into Tightly Packed Polyhedra and Redistribution of Platelets and Fibrin.  (Abstract #32)

Aasma Khan1*, Dongjun Li1*, Salam Ibrahim2*, Emer Smyth2* and Donna Douglas B. Cines, Tatiana Lebedeva, Chandrasekaran Nagaswami, Vincent Hayes, Walter Massefski, Rustem I. Litvinov, Lubica Rauova, Thomas J. Lowery, John W. Weisel.  University of Pennsylvania, Children’s Hospital of Philadelphia, T2 Biosystems.

2:45-3:00

The Parallel Signaling Pathways of Phosphatidylserine (PS) Exposure Downstream of Platelet FcgRIIa. (Abstract #27)

Pierrette Andre1, Steven E. McKenzie1, Wolfgang Bergmeier21Cardeza Foundation for Hematological Research, Thomas Jefferson University; 2Department of Biochemistry and Biophysics, University of North Carolina.

3:00-3:15

Zymogen-like FXa is an Effective Pro-Hemostatic to Reverse the Anticoagulant Effects of Direct FXa Inhibitors.  (Abstract #40)

Nabil K Thalji1, Sunita Patel-Hett2, Reema Jasuja2, Joachim Fruebis2, Debra D.Pittman2, and Rodney M Camire11 Pediatrics/Hematology, The Children’s Hospital of Philadelphia; 2 Pfizer, Cambridge, MA

3:15-3:30

Role of Monocyte Fcg Receptors in the Prothrombotic State of Heparin Induced Thrombocytopenia (HIT). (Abstract #14)

Daria Madeeva1, Valerie Tutwiler2,  Shahara Bailey1, Vincent Hayes1, Douglas B. Cines3, Mortimer Poncz1,4 and Lubica Rauova1,41Department of Pediatrics, Children’s Hospital of Philadelphia; 4Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania; 2School of Drexel University, and 3Department of Pathology and Clinical Laboratories, Perelman School of Medicine at the University of Pennsylvania.

3:30-3:45

Imaging morphologic changes on platelet and monocyte surfaces in heparin-induced thrombocytopenia (HIT).  (Abstract #29)

Lubica Rauova1,4, Yanjun Zhang6, Vincent Hayes1, Chandrasekaran Nagaswami2, Douglas B. Cines3, Jing-fei Dong5, Mortimer Poncz1,4, John W. Weisel21Departments of Pediatrics, 2Cell and Developmental Biology, 3Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania; and 4The Division of Hematology, The Children’s Hospital of Philadelphia; 5Puget Sound Blood Research Institute and the Department of Medicine, University of Washington; and 6Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China;

3:30-3:45

Plasma velocity and molecular transport between platelets regulate thrombus architecture.  (Abstract #31)

Maurizio Tomaiuolo, Timothy J. Stalker, John D. Welsh, T. Sinno, Scott L. Diamond, and Lawrence F. Brass.  University of Pennsylvania
4:00-5:30

Awards Ceremony and Cocktail Reception
(Eakins Lounge 1st Floor)

Remarks:  Leonard Edelstein, Ph.D.

Individual Awards for:
Oral Presentations
Poster Presentations

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