Program faculty laboratories are housed in research buildings fully equipped for investigations in cellular and molecular biology. These laboratories have active, NIH-funded research programs in a variety of areas. Research facilities available within the program cover all of the contemporary methods of cell and molecular biology. The university houses an outstanding biomedical research library.
Faculty Research Topics
Cell & Developmental Biology (CDB) faculty have a strong interest in mechanisms of cell differentiation and tissue development. Much of their research is focused on cell adhesion and signaling molecules and their role in regulating the transition between the undifferentiated and differentiated state. While a large number of systems are being investigated, our strengths are in ocular, bone, cartilage and neural development.
Chicken Embryo Development
Tissue Engineering & Regenerative Medicine
The concept of Tissue Engineering and Regenerative Medicine (TERM) is an emerging multidisciplinary field involving biology, medicine and engineering and is focused on restoring, maintaining or enhancing tissue and organ function.
Tissue Engineering & Regenerative Medicine offers a unique environment where instructors, staff and administration work as a team to make our students' educational and research experience memorable and productive. The program is organized by internationally recognized scientists who are faculty in a number of basic science and clinical departments within Thomas Jefferson University.
Research Interests of Program Faculty in Regenerative Medicine
|Principal Investigators||Areas of Research|
|George Feldman, PhD, DMD||Mutational Analysis of Hip Dysplasia|
|Andrzej Fertala, PhD||Use of "Smart Collagen" for Tissue Engineering
|Theresa Freeman, PhD||Effects of Plasma Discharge on Cell Function & Renewal|
|Noreen J. Hickok, PhD||Bone Biomaterial Interaction & Implant Design
Tissue Engineering of Bone & Cartilage
|Sergio Jimenez, MD||Pathogenesis of Osteoarthritis & Scleroderma|
|Javad Parvizi, FRCS, MD||Periprosthetic Joint Infection
Pathophysiology of Arthritis
|Makarand V. Risbud, PhD||Tissue-Engineering Based Strategies for Intervertebral Disc Regeneration|
|Irving M. Shapiro, BDS, PhD||Bone & Cartilage Formation
Mechanisms of Biological Mineralization
Design of Implant Materials
Origin and Function of Cells of the Intervertebral Disc
|Principal Investigators||Areas of Research|
|Sophie Astrof, PhD||Cellular & Molecular Mechanisms of Cardiovascular Development
Function of Tissue Microenvironment During Development of the Vertebrate Heart from Cardiac Progenitors
|Paul DiMuzio, MD, FACS||Tissue Engineering of Vascular Grafts|
|Gerald B. Grunwald, PhD||Role of Cadherin Cell Adhesion Molecules in Embryonic Development|
|Jan B. Hoek, PhD||Early Signaling Responses During Liver Regeneration|
|Lorraine Iacovitti, PhD||Mechanisms of Neuronal Cell Differentiation & Development of Neurotransmitter Class
Application of Immortalized Stem Cells to Treat Neurodegenerative Diseases such as Parkinson's & Alzheimer's
|Renato Iozzo, MD||Biology of Proteoglycans & Their Roles in Cancer and Angiogenesis|
|Steven B. McMahon, PhD||The Ubiquitin Hydrolase USP22 & Cancer Stem Cells|
|A. Sue Menko, PhD||Tissue Development, Wound Healing & Tissue Regeneration|
|Jay S. Schneider, PhD||Compensatory Mechanisms After Injury & "Neurorestoration" - Approaches to Get Dysfunctional or Injured Neurons to Function More Normally|
|Jouni J. Uitto, MD, PhD||Molecular Biology of the Cutaneous Basement Membranes|
|Rajanikanth Vadigepalli, PhD||Regulatory Network Dynamics Driving the Cellular Adaptive Processes in Mammalian Pathophysiology|
|Scott A. Waldman, PhD||Molecular Mechanisms Underlying Tissue-Specific Transcriptional Regulation|
Pathobiology of Disease
Members of our faculty are engaged in studies of the Pathobiology of Disease, many with a focus on age-related diseases. Investigators examine:
- The role of cell adhesion molecules in disease
- The effects of alcohol on cell function and its role in disease
- The regulation of cell death pathways
- The role of signaling pathways in cell growth and disease
There is also research strength in the pathobiology of degenerative diseases including Parkinson’s Disease, Alzheimer’s Disease and cataract and retinal degeneration.
Tourdot, B., Conaway, S., Niisuke, K., Edelstein, L., Bray, P., and M.
Holinstat 2014. Mechanism of race-dependent platelet activation through the PAR4 and Gq signaling axis. ATVB (pending resubmission).
Y Hirose, Z Johnson, Z Schoepflin, D Markova, , K Chiba, Y Toyama, I Shapiro, M Risbud. 2014 FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells. J. Biol. Chem. Jul 25;289(30):20594-20605.
Johnson, Zariel I., Shapiro, Irving M., Risbud, Makarand V., Extracellular Osmolarity Regulates Matrix Homeostasis in the Intervertebral Disc and Articular Cartilage: Evolving role of TonEBP, Matrix Biology (2014), doi:10.1016/j.matbio.2014.08.014