Thomas Jefferson University
PhD Programs

Research


Facilities

Research equipment

Program faculty laboratories are housed in research buildings fully equipped for investigations in cellular and molecular biology. These laboratories have active, NIH-funded research programs in a variety of areas. Research facilities available within the program cover all of the contemporary methods of cell and molecular biology. The university houses an outstanding biomedical research library.

Faculty Research Topics

Developmental Biology

Developmental Biology

Cell & Developmental Biology (CDB) faculty have a strong interest in mechanisms of cell differentiation and tissue development. Much of their research is focused on cell adhesion and signaling molecules and their role in regulating the transition between the undifferentiated and differentiated state.  While a large number of systems are being investigated, our strengths are in ocular, bone, cartilage and neural development.

Principal Investigators

Chicken Embryo Development

Tissue Engineering & Regenerative Medicine

Bone image

The concept of Tissue Engineering and Regenerative Medicine (TERM)  is an emerging multidisciplinary field involving biology, medicine and engineering and is focused on restoring, maintaining or enhancing tissue and organ function.

Tissue Engineering & Regenerative Medicine offers a unique environment where instructors, staff and administration work as a team to make our students' educational and research experience memorable and productive. The program is organized by internationally recognized scientists who are faculty in a number of basic science and clinical departments within Thomas Jefferson University. 

Research Interests of Program Faculty in Regenerative Medicine

Key Faculty
Principal Investigators Areas of Research
George Feldman, PhD, DMD Mutational Analysis of Hip Dysplasia
Andrzej Fertala, PhD Use of "Smart Collagen" for Tissue Engineering
Skeletal Regeneration
Theresa Freeman, PhD Effects of Plasma Discharge on Cell Function & Renewal
Noreen J. Hickok, PhD Bone Biomaterial Interaction & Implant Design
Tissue Engineering of Bone & Cartilage
Sergio Jimenez, MD Pathogenesis of Osteoarthritis & Scleroderma
Javad Parvizi, FRCS, MD Periprosthetic Joint Infection
Pathophysiology of Arthritis
Makarand V. Risbud, PhD Tissue-Engineering Based Strategies for Intervertebral Disc Regeneration
Irving M. Shapiro, BDS, PhD Bone & Cartilage Formation
Mechanisms of Biological Mineralization
Design of Implant Materials
Origin and Function of Cells of the Intervertebral Disc
Additional Faculty
Principal Investigators Areas of Research
Sophie Astrof, PhD Cellular & Molecular Mechanisms of Cardiovascular Development
Function of Tissue Microenvironment During Development of the Vertebrate Heart from Cardiac Progenitors
Paul DiMuzio, MD, FACS Tissue Engineering of Vascular Grafts
Gerald B. Grunwald, PhD Role of Cadherin Cell Adhesion Molecules in Embryonic Development
Jan B. Hoek, PhD Early Signaling Responses During Liver Regeneration
Lorraine Iacovitti, PhD Mechanisms of Neuronal Cell Differentiation & Development of Neurotransmitter Class
Application of Immortalized Stem Cells to Treat Neurodegenerative Diseases such as Parkinson's & Alzheimer's
Renato Iozzo, MD Biology of Proteoglycans & Their Roles in Cancer and Angiogenesis
Steven B. McMahon, PhD The Ubiquitin Hydrolase USP22 & Cancer Stem Cells
A. Sue Menko, PhD Tissue Development, Wound Healing & Tissue Regeneration
Jay S. Schneider, PhD Compensatory Mechanisms After Injury & "Neurorestoration" - Approaches to Get Dysfunctional or Injured Neurons to Function More Normally
Jouni J. Uitto, MD, PhD Molecular Biology of the Cutaneous Basement Membranes
Rajanikanth Vadigepalli, PhD Regulatory Network Dynamics Driving the Cellular Adaptive Processes in Mammalian Pathophysiology
Scott A. Waldman, PhD Molecular Mechanisms Underlying Tissue-Specific Transcriptional Regulation

Pathobiology of Disease

Cell illustrations

Members of our faculty are engaged in studies of the Pathobiology of Disease, many with a focus on age-related diseases. Investigators examine:

  • The role of cell adhesion molecules in disease
  • The effects of alcohol on cell function and its role in disease
  • The regulation of cell death pathways
  • The role of signaling pathways in cell growth and disease

There is also research strength in the pathobiology of degenerative diseases including Parkinson’s Disease, Alzheimer’s Disease and cataract and retinal degeneration.

Principal Investigators

Student Publications

Anil Antony

Erick Blomain

Stanley Conaway

Tourdot, B., Conaway, S., Niisuke, K., Edelstein, L., Bray, P., and M.
Holinstat 2014. Mechanism of race-dependent platelet activation through the PAR4 and Gq signaling axis. ATVB (pending resubmission).

Stephen Hurst

Recent Publications

Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter

Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling

Molecular and functional identification of a mitochondrial ryanodine receptor in neurons

Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts

Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor

IL-25 regulates Th17 function in autoimmune inflammation

TWEAK attenuates the transition from innate to adaptive immunity

Airway generation-specific differences in the spatial distribution of immune cells and cytokines in allergen-challenged rhesus monkeys

T cells that cannot respond to TGF-β escape control by CD4+ CD25+ regulatory T cells

Quantification of cortical bone loss and repair for therapeutic evaluation in collagen-induced arthritis, by micro-computed tomography and automated image analysis

Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation

New IL-17 family members promote Th1 or Th2 responses in the lung: In vivo function of the novel cytokine IL-25

Donor T cell activation initiates small bowel allograft rejection through an IFN-γ-inducible protein-10-dependent mechanism

Inflammatory mediators in uveitis: Differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation

IL-25 Induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo

Modulation of inhaled antigen-induced IgE tolerance by ongoing Th2 responses in the lung

Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide

T regulatory cells 1 inhibit a Th2-specific response in vivo

Interferon gamma induction during oral tolerance reduces T-cell migration to sites of inflammation

The differentiated state of intestinal lamina propria CD4+ T cells results in altered cytokine production, activation threshold, and costimulatory requirements

Zariel Johnson

Crystal Kraft

Christopher McNair

Greg Omerza

Carmella Romeo

Zachary Schoepflin

Annabel Torres