Yuri K. Sykulev, MD, PhD
Professor, Department of Microbiology & Immunology

Contact
233 South 10th Street
Bluemle Life Sciences Building 706
Philadelphia, PA 19107
215-503-4530
215-923-4153 fax
Yuri K. Sykulev, MD, PhD
Professor, Department of Microbiology & Immunology
Research and Clinical Interests
The major goal of my research program is to understand molecular mechanisms regulating various activities of cytotoxic lymphocytes. Understanding of these mechanisms, particularly those that lead to the lymphocyte activation and inactivation, is expected to facilitate the development of novel approaches to manipulate lymphocytes receptor-mediated signaling and their responsiveness and would lead to the development of novel immunotherapeutic interventions to treat viral infections, cancer and other diseases.
Publications
- Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs
- The DISC1–Girdin complex – a missing link in signaling to the T cell cytoskeleton
- Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides
- Extent of MHC clustering regulates selectivity and effectiveness of T cell responses
- Assessment of the synaptic interface of primary human t cells from peripheral blood and lymphoid tissue