PhD, Harvard University (Biophysics) - 1995
Medical School
MD, Harvard University - 1997
Fellowship
Postdoctoral Fellow, Whitehead Institute for Biomedical Research
Michael J. Root, MD, PhD
Professor
Professor
Education
Publications
- Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env
- Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators
- Characterization of resistance to a potent d-peptide HIV entry inhibitor
- Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors
- Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity
Biograhpy & Research
His research utilizes biophysical approaches to understand the mechanisms by which HIV enters human cells, with publications appearing in PNAS, Science, and PLOS Pathogens.
Beyond research, Dr. Root has also held significant leadership roles in graduate and medical education at both Thomas Jefferson University and OSU. At Jefferson, he served as the Assistant Dean for graduate affairs in the Jefferson College of Life Sciences, was a member of the Steering Committee that led to the JeffMD curricular redesign within SKMC, and served as Director of the Integrated Structural Biology Facility within the Sidney Kimmel Comprehensive Cancer Center. Similarly, Dr. Root held a number of leadership roles at OSU, including as Director of the Master’s Program in Medical Sciences. In addition to his role in the Department of Biochemistry and Molecular Biology, Dr. Root will assume roles in both graduate and medical education at Jefferson.