Dr. Martinez-Outschoorn’s research centers on how cancer cells interact metabolically with surrounding stromal cells, particularly in head and neck squamous cell carcinoma (HNSCC). He has shown that cigarette smoke alters cell metabolism in HNSCC, creating a tumor environment that supports cancer growth. He leads a lab focused on studying these metabolic profiles and has secured dedicated research funding. In breast cancer, his NIH-funded work explores how metabolic coupling between epithelial and stromal cells drives antiestrogen resistance, including investigations into the potential of N-acetylcysteine to reverse this effect.
Ubaldo Martinez-Outshoorn, MD
Professor
Contact Information
Honickman Center
1101 Chestnut Street
14th Floor
Philadelphia, PA 19107
Professor
RESEARCH & CLINICAL INTEREST
Education
Medical School
Universidad Complutense De Madrid, Spain - 2002
Residency
Thomas Jefferson University Hospital
Fellowship
Thomas Jefferson University Hospital
Most Recent Peer-Reviewed Publications
- Response-Adaptive Surgical Timing in Neoadjuvant Immunotherapy Demonstrates Enhanced Pathologic Treatment Response in Head and Neck Squamous Cell Carcinoma
- TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis
- Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma
- MiR-200c reprograms fibroblasts to recapitulate the phenotype of CAFs in breast cancer progression
- Hodgkin Lymphoma: A disease shaped by the tumor micro- and macroenvironment
Board Certifications
Internal Medicine
Medical Oncology
Hematology