- VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia
- Understanding how a highly prevalent GRK5 polymorphism affects platelets and enhances thrombotic risk
- Platelet-Associated microRNAs as Markers of Aspirin Response and Pregnancy Outcome in Pregnancies at High-Risk for Preeclampsia
- Heparin-induced thrombocytopenia immune complexes activate the inflammasome pathway in a complement-dependent manner
- Platelet defects in patients and mice with Ehlers-Danlos syndrome
Steven E. McKenzie, MD, PhD
Professor of Medicine
Cardeza Foundation for Hematologic Research
Contact Information
1020 Locust Street
Suite 394
Philadelphia, PA 19107
215-955-8544
215-955-9170 fax
Professor of Medicine
Cardeza Foundation for Hematologic Research
Publications
Research & Clinical Interests
Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes. This work, done in collaboration with Dr. Michael Reilly, led to the first model of heparin-induced thrombocytopenia and thrombosis. New work on effects of elevated cholesterol and athrosclerosis on HITT, and on microparticles and tissue factor, is ongoing.