David Abraham, PhD
Professor
Contact
233 South Tenth Street
Bluemle Life Sciences Building, Room 530
Philadelphia, PA 19107
215-503-8917
215-923-9248 fax
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David Abraham, PhD
Professor
Education
Education
BS, City College of New York, Biology - 1973
MS, Tulane University, Parasitology - 1977
PhD, University of Pennsylvania, Parasitology - 1983
Fellowships
University of Pennsylvania (1983-1984)
University of Wisconsin (1984-1987)
Most Recent Peer-Reviewed Publications
- A rodent model for Dirofilaria immitis, canine heartworm: parasite growth, development, and drug sensitivity in NSG mice
- Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to Onchocerca volvulus in Mice and Non-Human Primates
- Is Strongyloides stercoralis hyperinfection induced by glucocorticoids a result of both suppressed host immunity and altered parasite genetics?
- Co-Administration of Adjuvanted Recombinant Ov-103 and Ov-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine Onchocerca ochengi Infection Model of Human Onchocerciasis
- Development of a Vaccine Against Onchocerca volvulus
Expertise & Research Interests
Role of eosinophils, neutrophils and macrophages in innate and adaptive immunity to nematode infections. The goal of these studies is to define at a molecular level the mechanisms used by these cells, from both humans and mice, to kill parasites and to identify the immune evasion mechanisms used by the parasites
Vaccine development against parasitic helminths. Multivalent vaccines are being developed against Onchocerca volvulus, the causative agent of river blindness, and against Stongyloides stercoralis. The basis of the vaccines will the combination of recombinant antigens with adjuvants capable of inducing specific types of immune responses.
Patents
5,714,170; 6,312,684; 6,506,415; 6,541,036