Michael R. Sperling, MD
Baldwin Keyes Professor of Neurology
Vice Chair for Research - Neurology
Division Chief for Epilepsy
Director, Jefferson Comprehensive Epilepsy Center
Director, Clinical Neurophysiology Laboratory
Contact
901 Walnut Street
Suite 400
Philadelphia, PA 19107
215-955-1222
215-955-0606 fax
Michael R. Sperling, MD
Baldwin Keyes Professor of Neurology
Vice Chair for Research - Neurology
Division Chief for Epilepsy
Director, Jefferson Comprehensive Epilepsy Center
Director, Clinical Neurophysiology Laboratory
Education
Medical School
Temple University School of Medicine
Residency
Mount Sinai Medical Center
Fellowship
UCLA Medical Center
Publications
- Web-based decision support system for patient-tailored selection of antiseizure medication in adolescents and adults: An external validation study
- The EpiPick algorithm to select appropriate antiseizure medications in patients with epilepsy: Validation studies and updates
- Accuracy of high-frequency oscillations recorded intraoperatively for classification of epileptogenic regions
- Post hoc analysis of a phase 3, multicenter, open-label study of cenobamate for treatment of uncontrolled focal seizures: Effects of dose adjustments of concomitant antiseizure medications
- Efficacy of cenobamate for uncontrolled focal seizures: Post hoc analysis of a Phase 3, multicenter, open-label study
Board Certifications
Neurology
Neurology, Clinical Neurophysiology
Neurology, Epilepsy
Hospital Appointment
Thomas Jefferson University Hospital
Research & Clinical Interests
Surgical treatment of epilepsy: outcome after surgery, predictors of surgical outcome, neurobehavioral effects of surgery;
Mortality in epilepsy: research examining features associated with increased mortality in patients with epilepsy;
Electrophysiology of epilepsy: studies of EEG in epilepsy, intracranial EEG in epilepsy examining features related to seizure control, seizure propagation and spread;
Genetics of epilepsy: project examining genetic factors predisposing to heightened susceptibility for epilepsy;
Electrophysiology of cognition;
Investigational therapeutics in epilepsy: participation in multiple studies of new pharmaceuticals and devices to treat epilepsy.
Hospital Appointments
Graduate Hospital, Philadelphia, PA
Director, Neurophysiology Laboratory, 1985 - 1997
Director, Epilepsy Monitoring Unit 1985 - 1997
Director, Comprehensive Epilepsy Center, 1995- 1997
Thomas Jefferson University Hospital, Philadelphia, PA
Director, Jefferson Comprehensive Epilepsy Center, 1997 - present
Director, Clinical Neurophysiology Laboratory, 1997 - present
PROFESSIONAL ACTIVITIES
2002-2003
- President of Philadelphia Neurological Society
- Fellow, American Academy of Neurology
- Member, American Neurological Association
- Member, American Epilepsy Society
- Member, American Clinical Neurophysiology Society
1999-2000
- President of American Clinical Neurophysiology Society
Educational Activities
- Teaching medical students, residents and fellows.
- Regular instructor at resident and fellow epilepsy/neurophysiology conferences.
- Regular instructor at resident neurology conference.
Clinical Activities
- Developed Epilepsy Program at the Graduate Hospital, including design and development of the epilepsy monitoring unit and EEG laboratory, epilepsy surgical program (with Dr. Michael O'Connor), contributing to development of experimental antiepileptic drug program, and clinical research program.
- Developed the Comprehensive Epilepsy Center at Thomas Jefferson University, including designing and developing the epilepsy monitoring unit and EEG laboratory, epilepsy surgical program (with Dr. Michael O'Connor), experimental antiepileptic drug program, and clinical research program.
- Developed Intraoperative Brain Mapping Program at Thomas Jefferson University Hospital
Editorial Positions
- Editor-in-Chief, Epilepsia, 2014 – present
- Associate Editor: Epilepsia 2007 - 2014
- Epilepsy Research, 1999-2007
- Epilepsy Advances, 1993-95, 1996-1998
- Member - Editorial Board: Journal of Epilepsy, 1991-1999
- Reviewer: Electroencephalography and Clinical Neurophysiology, Annals of Neurology, Neurology, Epilepsia, Journal of Clinical Neurophysiology, Neuroradiology, Journal of Neurological Sciences, Archives of Neurology, JAMA, New England Journal of Medicine, Lancet