Cell Biology of Parkinson’s Disease
Richard J. Smeyne, PhD
Chair & Professor, Department of Neuroscience
Director, Jefferson Comprehensive Parkinson’s Center - Vickie & Jack Farber Institute for Neuroscience
Contact Information
Chair & Professor, Department of Neuroscience
Director, Jefferson Comprehensive Parkinson’s Center - Vickie & Jack Farber Institute for Neuroscience
Research & Clinical Interests
Publications
- Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
- GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults
- Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease
- Neuroanatomical and neurochemical effects of prolonged social isolation in adult mice
- Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson’s disease
Research & Clinical Interests
Cell Biology of Parkinson’s Disease