Charles J. Yeo, MD, FACS
Samuel D. Gross Professor and Chair of Surgery
Senior Vice President and Chair, Enterprise Surgery, Jefferson Health
Co-Director, Pancreas, Biliary and Related Cancer Center

Contact
1015 Walnut Street
Curtis Building, Suite 620
Philadelphia, PA 19107
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Charles J. Yeo, MD, FACS
Samuel D. Gross Professor and Chair of Surgery
Senior Vice President and Chair, Enterprise Surgery, Jefferson Health
Co-Director, Pancreas, Biliary and Related Cancer Center
Education
Medical School
Johns Hopkins University School of Medicine
Residency
Johns Hopkins Hospital
Fellowship
S.U.N.Y. Downstate Medical Center, Brooklyn, NY
Publications
- Euglycemic diabetic ketoacidosis (EDKA) after pancreaticoduodenectomy: An under-recognized metabolic abnormality with outcome implications
- John Alexander, MD (1891-1954): A Leader in Thoracic and Tuberculosis Surgery
- Preoperative sarcopenia is a negative predictor for enhanced postoperative recovery after pancreaticoduodenectomy
- KRAS mutation allele frequency threshold alters prognosis in right-sided resected pancreatic cancer
- The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma
Board Certification
Surgery
Hospital Appointment
Thomas Jefferson University Hospital
Awards
- Philadelphia Magazine's Top Docs 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009
- Castle Connolly's America's Top Doctors 2019, 2018, 2017, 2016, 2015,2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007
- Castle Connolly's America's Top Doctors for Cancer 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010
- Achievement Award in Medicine, Jefferson Health 2017
Education & Training
Dr. Charles J. Yeo was born in East Orange, New Jersey, and attended Spring Valley Senior High School in Spring Valley, New York. He received his undergraduate degree from Princeton University in 1975, summa cum laude with an A.B. in Biochemistry. Dr. Yeo graduated in 1979 from the Johns Hopkins University School of Medicine, being awarded the Upjohn Achievement Award and was elected to Alpha Omega Alpha and Phi Beta Kappa. While completing his internship and residency in General Surgery at the Johns Hopkins Hospital, he pursued a one year Research Fellowship at the S.U.N.Y. Downstate Medical Center in Brooklyn, N.Y.
Dr. Yeo joined the faculty of the Johns Hopkins University as an Instructor and Assistant Chief of Service in the Department of Surgery in 1985, and rose to the rank of Professor of Surgery in 1996. In 1997, he became a Professor in the Department of Oncology. Dr. Yeo directed the Pancreatic Cancer Interdisciplinary Working Group at Johns Hopkins, and served as the Surgical Clerkship Coordinator and Surgical Curriculum Consultant. In 2001, Dr. Yeo received the Alumni Association Excellence in Teaching Award from the Johns Hopkins University School of Medicine. In 2002, Dr. Yeo was named to an endowed chair at Johns Hopkins, becoming the inaugural John L. Cameron, MD, Professor for Alimentary Tract Diseases.
On October 1, 2005, Dr. Yeo was named the 8th Samuel D. Gross Professor and he assumed the chairmanship of the Department of Surgery at Sidney Kimmel Medical College at Thomas Jefferson University in Philadelphia, Pennsylvania.
In 2016, Dr. Yeo was named Senior Vice President and Chair of Enterprise Surgery at Jefferson Health. He currently serves on the Board of Trustees of the Thomas Jefferson University.
Clinical & Research Interests
Dr. Yeo's primary interests and research have been in the field of alimentary tract surgery, focusing on hepatopancreaticobiliary surgery - the evaluation of patients with pancreatic, biliary and related cancer, and the management of patients with unusual pancreatic neoplasms, as well as acute and chronic pancreatitis.
- Author of over 500 peer reviewed scientific papers, numerous abstracts, over 105 book chapters, and over 15 books or monographs
- Travels nationally and internationally teaching and lecturing on the treatment of benign and malignant pancreatic diseases
- Personally performed over 1700 Whipple procedures, and has treated well over 2100 patients with pancreatic and related cancers
Editorial Experience
- Editor-in-chief of the two-volume encyclopedic Shackelford's Surgery of the Alimentary Tract, 7th Edition, published in 2013
- Journal of Gastrointestinal Surgery
Co-Editor-in-Chief: 2011 – 2016
Associate Editor: 2006- 2011 - Case Reports in Pancreatic Cancer
Editor-in-Chief: 2015 – 2016 - Journal of Pancreatic Cancer
Editor-in-Chief: 2017 – present - Advances in Surgery
Associate Editor: 2009 – present - Editorial Boards:
- Annals of Surgery
- Hospital Practice
- Langenbeck’s Archives of Surgery
- Surgery (now emeritus)