Liquid-liquid phase separation drives the formation of membrane-less organelles such as stress granule. Aberrant protein phase transition leads to the formation of fibrils and aggregates implicated in various neurodegenerative diseases. We are interested in understanding the molecular mechanisms underlying these aberrant phase transitions and leveraging our understanding of phase transition to develop strategies with therapeutic potential to prevent and reverse these toxic events. We use a combination of biochemistry, molecular biology, cell biology, and biophysics techniques to tackle these problems.
Lin Guo, PhD
Assistant Professor, Department of Biochemistry & Molecular Biology
Contact Information
1020 Locust Street
Jefferson Alumni Hall, Room 411G
Philadelphia, PA 19107
Assistant Professor, Department of Biochemistry & Molecular Biology
Expertise & Research Interests
Education
PhD in Chemistry, University of Pennsylvania - 2011
BS, Pehing University, Beijing, China 2005
Publications
- NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats
- Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS
- Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS
- The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
- Single Acetylation-mimetic Mutation in TDP-43 Nuclear Localization Signal Disrupts Importin α1/β Signaling