Christine Eischen, PhD
Professor, Department of Cancer Biology
Special Advisor to the President, Thomas Jefferson University Hospitals

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Christine Eischen, PhD
Professor, Department of Cancer Biology
Special Advisor to the President, Thomas Jefferson University Hospitals
Research & Clinical Interests
The focus of the Eischen laboratory is to identify and study the genes that regulate cellular transformation. This is accomplished through approaches designed to test how specific genes impact cell proliferation, apoptosis, chromosomal stability, and DNA repair. We utilize mice and cell lines that lack or overexpress one or more genes and mice that are genetically engineered to spontaneously develop cancers. We also utilize patient samples. A large part of the laboratory studies B cell lymphoma, but there are also projects on carcinoma of the lung, breast, and ovary. Many of the genes we study are revealed to influence known oncogenic and tumor suppressor pathways linked to cancer. Currently, there are ongoing investigations into the genes that regulate or contribute to the oncogenic functions of Myc, Mdm2, and Ras and the tumor suppressor functions of Arf and p53. Studies to evaluate the role of specific miRNA in cellular transformation are also being performed. Our goal is to determine the function of novel genes/RNA or discover a new function for a known gene/RNA that increases understanding into tumorigenesis. Our research should also identify potential therapeutic targets that could lead to improved intervention strategies for the treatment of human malignancies.
Publications
- Engaging community members in cancer research: an assessment of an NCI-designated cancer center
- CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research
- Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming
- MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging
- Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression