Gyorgy Hajnoczky, MD, PhD
Raphael Rubin, MD Professor, Department of Pathology, Anatomy & Cell Biology; Director, Mitochondrial Research Center
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Gyorgy Hajnoczky, MD, PhD
Raphael Rubin, MD Professor, Department of Pathology, Anatomy & Cell Biology; Director, Mitochondrial Research Center
Research and Clinical Interests
Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.
Signaling, calcium, ER, mitochondria, metabolism, apoptosis, imaging
Medical School
MD, Semmelweis University, Budapest - 1987
PhD, Semmelweis University, Budapest - 1987
National Academy of Sciences, Hungary - 1995
Publications
- Capture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism
- Altered composition of the mitochondrial Ca2+uniporter in the failing human heart
- Reduced ER–mitochondria connectivity promotes neuroblastoma multidrug resistance
- Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts
- Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients