Lucia R. Languino, PhD
Professor, Department of Cancer Biology
Director, Genetics, Genomics, and Cancer Biology PhD Program

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Lucia R. Languino, PhD
Professor, Department of Cancer Biology
Director, Genetics, Genomics, and Cancer Biology PhD Program
Research and Clinical Interests
Studies of the signaling pathways that contribute to prostate cancer progression and metastasis.
Dr. Languino investigates the role of cell adhesion receptors in phenotypic changes of prostate cancer cells. A strong research focus is being devoted to the study of the cross-talk between cell adhesion molecules, extracellular matrix proteins and growth factor receptors in vitro and in vivo systems and how this cross-talk affects intracellular signal transduction, cell survival, cell migration and cell division. Dr. Languino's research interests also focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells
Publications
- Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability
- Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells
- IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles
- A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression
- Differential expression of avß3 and avß6 integrins in prostate cancer progression