The function of GRKs in hemostasis and thrombosis

We have recently provided strong evidence that GPCR kinases (GRKs) are critical negative regulators during platelet activation. Our goals are to investigate how GRKs regulate GPCRs during platelet activation and thrombus formation.

The regulatory networks that regulate platelet activation

Current studies are investigating novel positive regulators and negative regulators in response to GPCR-coupled agonists using genome-wide CRISPR-Cas9 screen. 

RGS-insensitive Gq (G188S) as probes of G protein functions

An ongoing study is to characterize the effect of G188S mutation on platelet function and thrombus formation downstream of GPCR-dependent signaling pathways.