Understanding the molecular mechanisms and the organizational logic of how synapses are constructed is essential to understanding neurotransmission in the brain. By knowing how connections form, when they form, and the rules they follow in comprising a circuit, we can understand how the brain processes information. By deciphering the genes involved in synapse formation and composition, we can also make great strides in understanding neurodevelopmental and intellectual disabilities. We combine genetics, state-of-the-art microscopy, biochemistry, and behavioral analysis to understand the links between molecules and function.
Timothy J. Mosca, PhD
Associate Professor, Department of Neuroscience
Contact Information
Associate Professor, Department of Neuroscience
Research & Clinical Interests
Publications
- ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles
- Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses
- A conditional strategy for cell-type-specific labeling of endogenous excitatory synapses in Drosophila
- SynLight: a bicistronic strategy for simultaneous active zone and cell labeling in the Drosophila nervous system
- γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor