Antigen presentation in viral infections and mechanisms of natural and acquired resistance to ectromelia virus.
Luis Sigal, DVM, PhD
Professor, Department of Microbiology & Immunology
Contact Information
Professor, Department of Microbiology & Immunology
Research & Clinical Interests
Publications
- The roles of CD4+ T cell help, sex, and dose in the induction of protective CD8+ T cells against a lethal poxvirus by mRNA-LNP vaccines
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
Most Recent Peer-Reviewed Publications
- A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding
- Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node
- With some risk-taking and luck: A veterinarian’s adventures in viral immunology
- Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts
- DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
- Activation of CD8 T Lymphocytes during Viral Infections
- The Pathogenesis and Immunobiology of Mousepox
- The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment
- Protective CD8+ T cell memory without help
- CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization
- Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection
- Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
- Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses
- MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2
- Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
- Immunology: Memory cells sound the alarm
- Memory CD8+ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection
- Getting in front and behind the enemy lines to counter virus infection
- Memory CD8+ T cell protection
- Characterization of ectromelia virus deficient in EVM036, thehomolog of vaccinia virus F13l, and its application for rapid generation of recombinant viruses