Luis Sigal, DVM, PhD

Professor, Department of Microbiology & Immunology

Sigal, Luis


233 South 10th Street
Room 709 BLSB
Philadelphia, PA 19107

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Luis Sigal, DVM, PhD

Professor, Department of Microbiology & Immunology

Research and Clinical Interests

Antigen presentation in viral infections and mechanisms of natural and acquired resistance to ectromelia virus.


Most Recent Peer-Reviewed Publications


  1. A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding
  2. Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node
  3. With some risk-taking and luck: A veterinarian’s adventures in viral immunology
  4. Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts
  5. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
  6. Activation of CD8 T Lymphocytes during Viral Infections
  7. The Pathogenesis and Immunobiology of Mousepox
  8. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment
  9. Protective CD8+ T cell memory without help
  10. CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization
  11. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection
  12. Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
  13. Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses
  14. MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2
  15. Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
  16. Immunology: Memory cells sound the alarm
  17. Memory CD8+ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection
  18. Getting in front and behind the enemy lines to counter virus infection
  19. Memory CD8+ T cell protection
  20. Characterization of ectromelia virus deficient in EVM036, thehomolog of vaccinia virus F13l, and its application for rapid generation of recombinant viruses