Cell Biology of Parkinson’s Disease
Richard J. Smeyne, PhD
Director, Jefferson Comprehensive Parkinson’s Center
Professor and Chair, Department of Neuroscience
Vickie and Jack Farber Institute for Neuroscience
Contact Information
Director, Jefferson Comprehensive Parkinson’s Center
Professor and Chair, Department of Neuroscience
Vickie and Jack Farber Institute for Neuroscience
Research and Clinical Interests
Publications
- Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
- GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults
- Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease
- Neuroanatomical and neurochemical effects of prolonged social isolation in adult mice
- Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson’s disease