Cell Biology of Parkinson’s Disease
Richard J. Smeyne, PhD
Director, Jefferson Comprehensive Parkinson’s Center
Professor and Chair, Department of Neuroscience
Vickie and Jack Farber Institute for Neuroscience
Contact Information
Director, Jefferson Comprehensive Parkinson’s Center
Professor and Chair, Department of Neuroscience
Vickie and Jack Farber Institute for Neuroscience
Research and Clinical Interests
Publications
- Persistent microglial activation following neonatal CMV infection mediates neurodegeneration
- Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
- Templating of monomeric alpha-synuclein results in inflammation and SNpc dopamine neuron death in a genetic mouse model of induced synucleinopathy
- GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults
- Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease